Results 91 to 100 of about 423,793 (299)

Calibr improves spectral library search for spectrum-centric analysis of data independent acquisition proteomics

Scientific Reports, 2022
Identifying peptides and proteins from mass spectrometry (MS) data, spectral library searching has emerged as a complementary approach to the conventional database searching. However, for the spectrum-centric analysis of data-independent acquisition (DIA)
Jen-Hung Wang, Wai-Kok Choong, Ching-Tai Chen, Ting-Yi Sung   +3 more
doaj   +1 more source

Novel applications of shotgun phage display [PDF]

, 2004
In a shotgun phage display library, theoretically, the entire proteome of a bacterium is represented. Phages displaying specific polypeptides can be isolated by affinity selection, while the corresponding gene remains physically linked to the gene ...
Rosander, Anna
core  

Current challenges in software solutions for mass spectrometry-based quantitative proteomics [PDF]

, 2012
This work was in part supported by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme; The Netherlands Proteomics Centre, embedded in The Netherlands Genomics Initiative; The Netherlands ...
A Alexandridou, A Gruhler, A Leitner, A Michalski, A Panchaud, A Thompson, A Wolf-Yadlin, AD Polpitiya, AHP America, AI Nesvizhskii, AI Nesvizhskii, AI Nesvizhskii, AJR Heck, Albert J. R. Heck, AM Mayampurath, B Breukelen van, B Carrillo, B Ma, B Macek, B Schwanhäusser, B Zybailov, BAP Roxas, Bas van Breukelen, BO Keller, C Christin, C Ji, C Kumar, CH Becker, CK Frese, C–C Tsou, D Chelius, D Hoof Van, D MacDougall, D Tsur, D Valkenborg, DH Lundgren, DK Han, DL Swaney, DL Tabb, DL Tabb, DM Good, DN Perkins, E Deutsch, E Qeli, EL Hendrickson, G Audi, GL Finney, H Lam, H Lam, H Liu, H Steen, H Steen, I Beer, IP Shadforth, J Cox, J Cox, J Elias, J Gouw, J Grossmann, J Klimek, J Listgarten, J Meija, J Rappsilber, J Seidler, J Zhang, JC Silva, JF Kellie, JF Timms, JV Olsen, K Flikka, K Kultima, K Podwojski, KA Neilson, KC Hansen, KL Simpson, L Martens, L Ting, LF Waanders, LK Iwai, LN Mueller, M Bantscheff, M Bantscheff, M Bern, M Junqueira, M Kohl, M Mann, M Sandin, M Senko, M Unlü, M Vandenbogaert, MA Baldwin, MA Grobei, MA Kuzyk, MC Codrea, ME Belov, ME Sardiu, MH Elliott, MJ MacCoss, MM Savitski, MW Duncan, N Colaert, N Mischerikow, N Wang, NM Griffin, OA Mirgorodskaya, P Lu, P Mallick, P Mortensen, Pedro R. Cutillas, Peter R. Baker, PJ Boersema, PL Ross, PR Baker, PR Cutillas, PR Cutillas, R Aebersold, R Clarke, R Matthiesen, R Matthiesen, R Purves, R Usaite, R Zhang, RA Bradshaw, RD Smith, RE Moore, RJ Chalkley, RJ Chalkley, RJ Jacob, S Cappadona, S Cappadona, S Carr, S Dasari, S Houel, S Julka, S Ong, S-E Ong, SA Beausoleil, SA Gerber, Salvatore Cappadona, SJ Callister, SK Park, SP Gygi, SY Ow, T Shinkawa, TM Annesley, TS Collier, TT Aye, V Faca, V Lange, VG Tusher, VP Andreev, W Weiss, W Yan, W Zhu, WM Old, WX Schulze, X Yang, Y Ishihama, Y Oda, YJ Kim, Z Khan, Z Khan, Z-Q Ma   +162 more
core   +2 more sources

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display library

Biological Procedures Online, 2004
We have identified a peptide substrate for molecular chaperone Hsp40 Ydj1 by utilizing the combination of phage display library screening and isothemol titration calirimetry (ITC).
Li Jingzhi, Sha Bingdong
doaj   +1 more source

LL‐37 Driven Phase Transition and Stacking in Oligolamellar Gram‐Negative Bacterial Membrane Models

Advanced Functional Materials, EarlyView.
This work establishes oligolamellar bacterial membrane models to investigate how LL‐37 disrupts the complex dual‐bilayer architecture of Gram‐negative bacteria. Combining SAXS, cryo‐TEM, electrophoretic mobility measurements, and coarse‐grained simulations, it reveals cardiolipin‐driven phase transitions leading to bicelle‐like structures and membrane ...
Bettina Tran, Diane C.A. Lima, Linda Sandblad, Madeleine Ramstedt, Thereza A. Soares, Stefan Salentinig   +5 more
wiley   +1 more source

Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A Motif in electron cycling [PDF]

, 2014
Background: The HbN of Mycobacterium tuberculosis carries a potent nitric-oxide dioxygenase activity despite lacking a reductase domain. Results: The NADH-ferredoxin reductase system acts as an efficient partner for the reduction of HbN.
Bidon Chanal, Axel, Datta, H., Dikshit, Kanak L., Estrin, Dario Ariel, Hade, Mangesh Dattu, Luque, F. Javier, Marti, Marcelo Adrian, Oliveira, Ana, Parkesh, R., Petruk, Ariel Alcides, Sethi, Deepti, Singh, Sandeep, Thakur, Naveen   +12 more
core   +2 more sources

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source

Synthesis of an arginine mimic for an antifungal octapeptide library : this thesis is presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University, Palmerston North, New Zealand [PDF]

, 2008
A family of bioactive antifungal octapeptides has been established¹⁻³. The template for this library is based on peptides composed of two predefined amino acids, three arginines, and three unknown components. The arginine contains a guanidino group (pKa =
Sun, Hao
core