Results 111 to 120 of about 254,967 (163)

Synthetic peptide libraries.

Methods in enzymology, 1997
Combinatorial chemistry is a rapidly developing field. It is now considered as one of the most important recent advances in medicinal chemistry. In addition to drug lead identification, combinatorial chemistry can also be applied to the optimization of the initial lead.
M, Lebl, V, Krchnák
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Phage Peptide Libraries

Methods, 1996
Filamentous phage particles have been central in the construction of libraries displaying vast numbers of random peptides. These random peptides can be antigenically presented as fusions to coat proteins III and VIII of the phage. The isolation of ligate-reactive phage from an immense background of nonspecific phage is achieved by the biopanning ...
, Daniels, , Lane
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A Conformationally Homogeneous Combinatorial Peptide Library

Journal of Molecular Biology, 1995
In search for a rational way to convert the information encoded in peptide structures into peptidomimetics, major progress could be made by coupling the power of selection methods, now enormously increased in number as a result of the development of combinatorial peptide libraries, with the rational design of structure-inducing templates for the ...
BIANCHI E, FOLGORI A, WALLACE A, NICOTRA M, ACALI S, PHALIPON A, BARBATO G, BAZZO R, CORTESE R, FELICI, Franco, PESSI A.   +10 more
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DNA-Encoded Macrocyclic Peptide Library

2019
DNA-encoded library technology (ELT) is a cutting-edge enabling technology platform for drug discovery. Here we describe how to design and synthesize a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity.
Zhengrong, Zhu, Alex, Shaginian, La Shadric C, Grady, Christopher P, Davie, Kenneth, Lind, Sandeep, Pal, Praew, Thansandote, Graham L, Simpson   +7 more
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Peptide and Peptide Library Cyclization via Bromomethylbenzene Derivatives

2014
Cyclization confers several advantages to peptides, cumulatively serving to make them more drug-like. In this protocol, cyclic peptides are generated via bis-alkylation of cysteine-containing peptides using α,α'-dibromo-m-xylene. The reactions are robust and high yielding.
David E, Hacker, Mohammed, Almohaini, Aruna, Anbazhagan, Zhong, Ma, Matthew C T, Hartman   +4 more
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Peptide libraries: criteria and trends

Trends in Genetics, 1993
The development of approaches for preparing peptide libraries, containing millions of different amino acid sequences of a specified length, provides an invaluable resource for characterizing the molecular interactions that underlie many biological processes.
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Peptide and Non-Peptide Combinatorial Libraries

2006
The field of combinatorial peptide chemistry was created when the first limited peptide library was synthesized with multipin technology in 1984. Since 1990, the field of combinatorial chemistry has advanced rapidly. It has emerged as a powerful tool in the study of many biological systems. In essence, a combinatorial peptide library (numbering 104–108
Ruiwu Liu, Kit S. Lam
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Implicit Biology in Peptide Spectral Libraries

Analytical Chemistry, 2012
Mass spectral libraries are collections of mass spectra curated specifically to facilitate the identification of small molecules, metabolites, and short peptides. One of the most comprehensive peptide spectral libraries is curated by NIST and contains upward of half a million annotated spectra dominated by human and model organisms including budding ...
Askenazi, Manor, Linial, Michal
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Screening Phage-Displayed Combinatorial Peptide Libraries

Methods, 2001
Among the many techniques available to investigators interested in mapping protein-protein interactions is phage display. With a modest amount of effort, time, and cost, one can select peptide ligands to a wide array of targets from phage-display combinatorial peptide libraries.
B K, Kay, J, Kasanov, M, Yamabhai
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Epitope mapping using bacteriophage peptide libraries

Current Opinion in Immunology, 1993
Vast libraries of random peptides displayed on the surface of bacteriophage potentially allow identification of specific ligands for any peptide receptor of interest. The sequence specificity of antibody-peptide interactions allows these libraries to be used to define and localize continuous epitopes.
D P, Lane, C W, Stephen
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