Prediction of Hemolysis Tendency of Peptides using a Reliable Evaluation Method [PDF]
arXiv, 2020 There are numerous peptides discovered through past decades, which exhibit antimicrobial and anti-cancerous tendencies. Due to these reasons, peptides are supposed to be sound therapeutic candidates. Some peptides can pose low metabolic stability, high toxicity and high hemolity of peptides.
arxiv
Advanced Healthcare Materials, EarlyView.In this study, a novel cationic peptide, IW is designed and synthesized, with a tandem‐repeat sequence demonstrating potent activities against a broad spectrum of clinically relevant Carbapenem‐resistant Enterobacteriaceae in both the planktonic and biofilm states. IW is then formulated with P407 to form IW‐P407 colloids.
Ping Zeng +5 more
wiley +1 more source
Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display library
Biological Procedures Online, 2004 We have identified a peptide substrate for molecular chaperone Hsp40 Ydj1 by utilizing the combination of phage display library screening and isothemol titration calirimetry (ITC).
Li Jingzhi, Sha Bingdong
doaj +1 more source
The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus [PDF]
, 2012 The work reported here was supported by a grant from the University of London Central Research ...
Elphick, MR, Rowe, ML
core +1 more source
Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases
Advanced Materials, EarlyView.This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu +16 more
wiley +1 more source
A machine learning approach to explore the spectra intensity pattern of peptides using tandem mass spectrometry data [PDF]
, 2008 Background: A better understanding of the mechanisms involved in gas-phase fragmentation of peptides is essential for the development of more reliable algorithms for high-throughput protein identification using mass spectrometry (MS).
Bowler, Lucas D. +2 more
core +5 more sources
De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties
Advanced Materials, EarlyView.NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang +25 more
wiley +1 more source
Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. [PDF]
, 2016 We identified drug seeds for treating Huntington's disease (HD) by combining in vitro single molecule fluorescence spectroscopy, in silico molecular docking simulations, and in vivo fly and mouse HD models to screen for inhibitors of abnormal ...
Chen, Xigui +17 more
core +2 more sources
Advanced Materials, EarlyView.This review systematically examines the nanomechanical mechanisms of mussel‐inspired molecular interactions, primarily investigated by direct force measurement techniques such as surface forces apparatus and atomic force microscopy. The macroscopic adhesive and self‐healing performances of mussel‐inspired functional materials, including coacervates ...
Pan Huang, Hongjian Zhang, Hongbo Zeng
wiley +1 more source
Selection of gonadotrophin surge attenuating factor phage antibodies by bioassay [PDF]
, 2005 Peer reviewedPublisher ...
Fowler, Paul Alfred Francois +3 more
core +3 more sources