Computational design of target-specific linear peptide binders with TransformerBeta [PDF]
arXivThe computational prediction and design of peptide binders targeting specific linear epitopes is crucial in biological and biomedical research, yet it remains challenging due to their highly dynamic nature and the scarcity of experimentally solved binding data.
arxiv
Advanced Science, EarlyView.The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou +11 more
wiley +1 more source
Construction of Peptide Library in Mammalian Cells by dsDNA-Based Strategy. [PDF]
ACS Omega, 2023 Su W +7 more
europepmc +1 more source
A graph-based approach for modification site assignment in proteomics [PDF]
arXivBackground In proteomics, the most probable localizations of post-translational modifications are assessed by localization scores evaluating the likelihood of a given modification to occupy a site on a peptide sequence. When identifying highly modified peptides, localization scores for different modifications can return conflicting results, stacking ...
arxiv
Discovery of Proteomics based on Machine learning [PDF]
arXiv, 2013 The ultimate target of proteomics identification is to identify and quantify the protein in the organism. Mass spectrometry (MS) based on label-free protein quantitation has mainly focused on analysis of peptide spectral counts and ion peak heights. Using several observed peptides (proteotypic) can identify the origin protein.
arxiv
Development of peptide-like library
, 2009 Peptide libraries are important in peptide based drug discovery and investigations of biological targets. Different chemical and biological methods have been developed to screen and decode peptide libraries. mRNA display technology is a biological method that utilizes in vitro translation systems to build peptide libraries, and the screened peptides ...
openaire +2 more sources
piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization
Advanced Science, EarlyView.PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang +16 more
wiley +1 more source
Low-Abundance Protein Enrichment for Medical Applications: The Involvement of Combinatorial Peptide Library Technique. [PDF]
Int J Mol Sci, 2023 Boschetti E, Righetti PG.
europepmc +1 more source
The Lymnaea Cardioexcitatory Peptide (LyCEP) Receptor: A G-Protein–Coupled Receptor for a Novel Member of the RFamide Neuropeptide Family [PDF]
, 1998 A novel G-protein–coupled receptor (GRL106) resembling neuropeptide Y and tachykinin receptors was cloned from the molluscLymnaea stagnalis. Application of a peptide extract from the Lymnaea brain to Xenopus oocytes expressing GRL106 activated a calcium ...
Burke, Julian F +13 more
core +7 more sources
Selection of human elastase inhibitors from a conformationally constrained combinatorial peptide library [PDF]
, 1999 Jeffrey D. McBride +2 more
openalex +1 more source