Results 211 to 220 of about 435,750 (350)

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

open access: yesAdvanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang   +17 more
wiley   +1 more source

A rationally designed injury kidney targeting peptide library and its application in rescuing acute kidney injury. [PDF]

open access: yesSci Adv
Xiao Y   +19 more
europepmc   +1 more source

Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA. [PDF]

open access: yesJ Biol Chem, 2021
Horsfall AJ   +6 more
europepmc   +1 more source

Identification of a protective B-cell epitope of the Staphylococcus aureus GapC protein by screening a phage-displayed random peptide library

open access: gold, 2018
Mengyao Wang   +14 more
openalex   +2 more sources

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

open access: yesAdvanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun   +23 more
wiley   +1 more source

Selection of CC Chemokine Receptor 5-Binding Peptide from a Phage Display Peptide Library [PDF]

open access: bronze, 2006
Fangyu Wang   +5 more
openalex   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

open access: yesAdvanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan   +12 more
wiley   +1 more source

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