Peptide Ligands to Human Immunodeficiency Virus Type 1 gp120 Identified from Phage Display Libraries
, 1999 Marc Ferrer, Stephen C. Harrison
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The specificity of the protein kinase C α, βII and γ isoforms as assessed by an unnatural alcohol-appended peptide library [PDF]
, 2000 Xiongwei Yan +2 more
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An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy
Advanced Science, EarlyView.This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma +14 more
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Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB [PDF]
, 2000 Toshiyuki Obata +7 more
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Advanced Science, EarlyView.A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin +11 more
wiley +1 more source
Deep Sequencing of a Systematic Peptide Library Reveals Conformationally-Constrained Protein Interface Peptides that Disrupt a Protein-Protein Interaction. [PDF]
Chembiochem, 2022 Boragine DM, Huang W, Su LH, Palzkill T.
europepmc +1 more source
Detection of small-molecule enzyme inhibitors with peptides isolated from phage-displayed combinatorial peptide libraries [PDF]
, 2000 Robin Hyde‐DeRuyscher +12 more
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Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury
Advanced Science, EarlyView.Dipyridamole acts as a clinically used compound to suppress ferroptosis. Dipyridamole down‐regulates the expression of RNF126, which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. The deficiency of SLC7A11 largely abolishes the protective role of dipyridamole both in vitro and in vivo.
Xiao Zhuang +22 more
wiley +1 more source
Advanced Science, EarlyView.In the tripartite‐species model, Drosophila larvae stimulate lactate production through excreting digestion enzymes. S. marcescens population senses a cue of lactate and tends to diverge into virulent and reduced virulence subclusters with remarkable heterogeneity to metabolize carbon metabolism and counter colonization resistance, giving a fitness ...
Sheng Zhang +10 more
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