Results 251 to 260 of about 281,224 (300)

Synthetic peptide libraries

Methods in enzymology, 1997
Combinatorial chemistry is a rapidly developing field. It is now considered as one of the most important recent advances in medicinal chemistry. In addition to drug lead identification, combinatorial chemistry can also be applied to the optimization of the initial lead.
Zhan-Gong Zhao, Kit S. Lam
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A Conformationally Homogeneous Combinatorial Peptide Library

Journal of Molecular Biology, 1995
In search for a rational way to convert the information encoded in peptide structures into peptidomimetics, major progress could be made by coupling the power of selection methods, now enormously increased in number as a result of the development of combinatorial peptide libraries, with the rational design of structure-inducing templates for the ...
BIANCHI E, FOLGORI A, WALLACE A, NICOTRA M, ACALI S, PHALIPON A, BARBATO G, BAZZO R, CORTESE R, FELICI, Franco, PESSI A.   +10 more
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Phage Peptide Libraries

Methods, 1996
Filamentous phage particles have been central in the construction of libraries displaying vast numbers of random peptides. These random peptides can be antigenically presented as fusions to coat proteins III and VIII of the phage. The isolation of ligate-reactive phage from an immense background of nonspecific phage is achieved by the biopanning ...
, Daniels, , Lane
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Peptide libraries: criteria and trends

Trends in Genetics, 1993
The development of approaches for preparing peptide libraries, containing millions of different amino acid sequences of a specified length, provides an invaluable resource for characterizing the molecular interactions that underlie many biological processes.
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Peptide and Non-Peptide Combinatorial Libraries

2006
The field of combinatorial peptide chemistry was created when the first limited peptide library was synthesized with multipin technology in 1984. Since 1990, the field of combinatorial chemistry has advanced rapidly. It has emerged as a powerful tool in the study of many biological systems. In essence, a combinatorial peptide library (numbering 104–108
Ruiwu Liu, Kit S. Lam
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Generation of bioactive peptides by biological libraries

Journal of Chromatography B, 2008
Biological libraries are powerful tools for discovery of new ligands as well as for identification of cellular interaction partners. Since the first development of the first biological libraries in form of phage displays, numerous biological libraries have been developed.
Christa, Mersich, Alois, Jungbauer
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Implicit Biology in Peptide Spectral Libraries

Analytical Chemistry, 2012
Mass spectral libraries are collections of mass spectra curated specifically to facilitate the identification of small molecules, metabolites, and short peptides. One of the most comprehensive peptide spectral libraries is curated by NIST and contains upward of half a million annotated spectra dominated by human and model organisms including budding ...
Askenazi, Manor, Linial, Michal
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Peptide and Peptide Library Cyclization via Bromomethylbenzene Derivatives

2014
Cyclization confers several advantages to peptides, cumulatively serving to make them more drug-like. In this protocol, cyclic peptides are generated via bis-alkylation of cysteine-containing peptides using α,α'-dibromo-m-xylene. The reactions are robust and high yielding.
David E, Hacker, Mohammed, Almohaini, Aruna, Anbazhagan, Zhong, Ma, Matthew C T, Hartman   +4 more
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Searching for Peptide Ligands with an Epitope Library

Science, 1990
Tens of millions of short peptides can be easily surveyed for tight binding to an antibody, receptor or other binding protein using an "epitope library." The library is a vast mixture of filamentous phage clones, each displaying one peptide sequence on the virion surface.
J K, Scott, G P, Smith
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Peptide and peptidomimetic libraries

Molecular Biotechnology, 1998
Various techniques for generation of peptide and peptidomimetic libraries are summarized in this article. Multipin, tea bag, and split-couple-mix techniques represent the major methods used to make peptides and peptidomimetics libraries. The synthesis of these libraries were made in either discrete or mixture format.
F, al-Obeidi, V J, Hruby, T K, Sawyer
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