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DNA-Encoded Macrocyclic Peptide Library
2019DNA-encoded library technology (ELT) is a cutting-edge enabling technology platform for drug discovery. Here we describe how to design and synthesize a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity.
Zhengrong, Zhu +7 more
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Encoded libraries of chemically modified peptides
Current Opinion in Chemical Biology, 2015The use of powerful technologies for generating and screening DNA-encoded protein libraries has helped drive the development of proteins as pharmaceutical ligands. However the development of peptides as pharmaceutical ligands has been more limited.
Heinis C, Winter G
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Peptide libraries: at the crossroads of proteomics and bioinformatics
Current Opinion in Chemical Biology, 2003Peptide libraries offer a valuable means for providing functional information regarding protein-modifying enzymes and protein interaction domains. Library approaches have become increasingly useful as high-throughput strategies for the analysis of large numbers of new proteins identified as a result of genome-sequencing efforts.
Benjamin E, Turk, Lewis C, Cantley
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Construction and screening of biological peptide libraries
Current Opinion in Biotechnology, 1994Significant advances have been made recently in technology to construct and screen peptide libraries using biological systems. Progress has been achieved in increasing the size of libraries, in controlling affinity of the peptides isolated, and in understanding the constraints imposed by the biology of the expression systems employed.
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PEPTIDE DISPLAY LIBRARIES: DESIGN AND CONSTRUCTION*
Journal of Receptors and Signal Transduction, 2001The biological display of peptides requires the introduction into a microorganism of the genetic information (DNA) that codes for the peptides (Fig. 1).
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1998
Abstract Chapters 2 and 3 described the explosive growth in methods for the rapid synthesis of peptide libraries, primarily for immunological studies, reflecting the critical role played by solid phase peptide chemists in the initial development of combinatorial chemistry methods. Following the seminal 1991 Naturepapers from Houghton and
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Abstract Chapters 2 and 3 described the explosive growth in methods for the rapid synthesis of peptide libraries, primarily for immunological studies, reflecting the critical role played by solid phase peptide chemists in the initial development of combinatorial chemistry methods. Following the seminal 1991 Naturepapers from Houghton and
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Comparative conformational analysis of peptide libraries
Molecular Diversity, 1998Six computer-based combinatorial libraries, including tetrapeptide sequences (generated with five amino acids) and conformations (generated with five main chain and three side chain rotamers), were obtained and sequence-conformation probabilities were calculated with a molecular and statistical mechanics procedure.
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Peptide Libraries in Cellular Immune Recognition
1999Protective immunity against microbial pathogens is connected with the ability to discriminate between self and non-self. Vertebrates have evolved an adaptive immune system in which specialized white blood cells, the T cells, fulfill this role. These cells are trained to recognize proteolytic fragments of viral, bacterial or parasitic antigens in the ...
S, Uebel +3 more
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MS Ana: Improving Sensitivity in Peptide Identification with Spectral Library Search
Journal of Proteome Research, 2023Sebastian Dorl +2 more
exaly