Results 51 to 60 of about 281,224 (300)

Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop

Neural Regeneration Research, 2015
Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown.
Ling-ling Shen, Ming-liang Jiang, Si-si Liu, Min-chun Cai, Zhong-qiu Hong, Li-qing Lin, Yan-yan Xing, Gui-lin Chen, Rui Pan, Li-juan Yang, Ying Xu, Jun Dong   +11 more
doaj   +1 more source

A peptide filtering relation quantifies MHC class I peptide optimization

, 2011
Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Luca Cardelli, Goldstein, LD, Phillips, Andrew, Emmott, Stephen, Elliott, T, Mark Howarth, Werner, JM, Werner, Joern M., Leonard D. Goldstein, Andrew Phillips, Elliot, Tim, Dalchau, Neil, Goldstein, Leonard D., Cardelli, L, Cardelli, Luca, Tim Elliott, Dalchau, N, Emmott, S, Neil Dalchau, Howarth, M, Elliott, Tim, Leonard D Goldstein, Joern M. Werner, Phillips, A, Joern M Werner, Stephen Emmott, Howarth, Mark   +26 more
core   +1 more source

Mixture-Based Combinatorial Libraries from Small Individual Peptide Libraries: A Case Study on α1-Antitrypsin Deficiency

Molecules, 2014
The design, synthesis and screening of diversity-oriented peptide libraries using a “libraries from libraries” strategy for the development of inhibitors of α1-antitrypsin deficiency are described. The major buttress of the biochemical approach presented
Yi-Pin Chang, Yen-Ho Chu
doaj   +1 more source

Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag?TSG101 interaction

, 2008
The egress of HIV particles from virus-infected cells is accomplished by the recruitment of proteins that normally mediate host cell endocytic functions.
Gam, Jongsik, Cohen, Stanley N., Benkovic, Stephen J., Pans, Hui, Tavassoli, Ali, Lu, Quan   +5 more
core   +1 more source

Synthesis and Screening of a Combinatorial Peptide Library for Ligands to Target Transferrin: Miniaturizing the Library [PDF]

, 2010
Combinatorial libraries are used in the search for ligands that bind to target proteins. Fmoc solid-phase peptide synthesis is routinely used to generate such libraries. Microwave-assisted peptide synthesis was employed here to decrease reaction times by
Brown, Jennifer Marie
core   +1 more source

A deeper mining on the protein composition of VA-MENGOC-BC®: An OMV-based vaccine against N. meningitidis serogroup B and C

Human Vaccines & Immunotherapeutics, 2017
The protein composition of an Outer Membrane Vesicle (OMV) preparation that constitutes the active pharmaceutical ingredient of VA-MENGOC-BC®, an effective vaccine against Neisseria meningitidis serogroups B, and C is presented.
Yordanka Masforrol, Jeovanis Gil, Darien García, Jesús Noda, Yassel Ramos, Lázaro Betancourt, Osmany Guirola, Sonia González, Boris Acevedo, Vladimir Besada, Osvaldo Reyes, Luis Javier González   +11 more
doaj   +1 more source

Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report

Neural Regeneration Research, 2015
In this report, we present the results of a single patient with optic neuropathy treated within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical trial and is the largest ophthalmology stem cell
Jeffrey N Weiss, Steven Levy, Alexis Malkin   +2 more
doaj   +1 more source

Biomathematical Description of Synthetic Peptide Libraries

PLOS ONE, 2015
Libraries of randomised peptides displayed on phages or viral particles are essential tools in a wide spectrum of applications. However, there is only limited understanding of a library's fundamental dynamics and the influences of encoding schemes and sizes on their quality.
Sieber, Timo, Hare, Eric, Hofmann, Heike, Trepel, Martin   +3 more
openaire   +5 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source