Results 51 to 60 of about 257,591 (258)

Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection

open access: yesNeural Regeneration Research, 2015
The morphological changes that occur in the taste buds after denervation are not well understood in rats, especially in the contralateral tongue epithelium.
Yi-ke Li   +4 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues

open access: yesNeural Regeneration Research, 2015
The extracellular matrix (ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM ...
Éva Korpos, Ferenc Deák, Ibolya Kiss
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

open access: yesFEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Phage display: development of nanocarriers for targeted drug delivery to the brain

open access: yesNeural Regeneration Research, 2015
The blood brain barrier represents a formidable obstacle for the transport of most systematically administered neurodiagnostics and neurotherapeutics to the brain.
Babak Bakhshinejad   +2 more
doaj   +1 more source

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

open access: yesNature Communications, 2021
Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-CoV-2
Thomas Kruse   +21 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

Man-Made Synthetic Receptors for Capture and Analysis of Ochratoxin A

open access: yesToxins, 2015
Contemporary analytical methods have the sensitivity required for Ochratoxin A detection and quantification, but direct application of these methods on real samples can be rarely performed because of matrix complexity.
Claudio Baggiani   +2 more
doaj   +1 more source

Calibr improves spectral library search for spectrum-centric analysis of data independent acquisition proteomics

open access: yesScientific Reports, 2022
Identifying peptides and proteins from mass spectrometry (MS) data, spectral library searching has emerged as a complementary approach to the conventional database searching. However, for the spectrum-centric analysis of data-independent acquisition (DIA)
Jen-Hung Wang   +3 more
doaj   +1 more source

Combinatorial Peptide Libraries: Mining for Cell-Binding Peptides [PDF]

open access: yesChemical Reviews, 2013
The surface of a cell represents a collection of macromolecules, which provides the cell with a unique cellular landscape specific to the type and state of the cell. Ligands that discriminate between subtle differences in cell surface phenotypes have utility in a wide variety of research and clinical applications.
Bethany Powell, Gray, Kathlynn C, Brown
openaire   +2 more sources

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