Results 61 to 70 of about 423,793 (299)

Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain

Neural Regeneration Research, 2015
In the aging brain, cognitive function gradually declines and causes a progressive reduction in the structural and functional plasticity of the hippocampus. Transcranial magnetic stimulation is an emerging and novel neurological and psychiatric tool used
Zhan-chi Zhang, Feng Luan, Chun-yan Xie, Dan-dan Geng, Yan-yong Wang, Jun Ma   +5 more
doaj   +1 more source

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. [PDF]

, 2011
Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides.
Bauman, Jonathan N, Gelev, Vladimir M, Jacobson, Matthew P, Kalgutkar, Amit S, Leung, Siegfried SF, Linington, Roger G, Liras, Spiros, Lokey, R Scott, Mathiowetz, Alan M, McEwen, Cayla M, Price, David A, Rand, Arthur C, Renzelman, Chad M, Rezai, Taha, Turner, Rushia A, White, Tina R, Zhang, Yizhong   +16 more
core   +1 more source

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Paradis-Bleau , Catherine, Lloyd, Adrian, Sanschagrin, François, Clark, Tom, Blewett, Ann, Bugg, Tim, Levesque, Roger C.   +6 more
core   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains [PDF]

, 2018
Alpha helices form a critical part of the binding interface for many protein-protein interactions, and chemically stabilized synthetic helical peptides can be effective inhibitors of such helix-mediated complexes.
Keating, Amy E., Letai, Anthony, Rezaei Araghi, Raheleh, Ryan, Jeremy Adam   +3 more
core   +1 more source

Genetically Encoded Libraries of Constrained Peptides [PDF]

ChemBioChem, 2019
AbstractMany therapeutic peptides can still be improved with respect to target specificity, target affinity, resistance to peptidases/proteases, physical stability, and capacity to pass through membranes required for oral delivery. Several modifications can improve the peptides’ properties, in particular those that impose (a) conformational constraint ...
Tjibbe Bosma, Rick Rink, Markus A. Moosmeier, Gert N. Moll   +3 more
openaire   +3 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury

Neural Regeneration Research, 2015
Increasing evidence indicates that sialic acid plays an important role during nerve regeneration. Sialic acids can be modified in vitro as well as in vivo using metabolic oligosaccharide engineering of the N-acyl side chain.
Christian Witzel, Werner Reutter, G Björn Stark, Georgios Koulaxouzidis   +3 more
doaj   +1 more source

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning. [PDF]

, 1995
Identifying the immunogenic proteins that elicit pathogen-specific T cell responses is key to rational vaccine design. While several approaches have succeeded in identifying major histocompatibility complex (MHC) class I bound peptides that stimulate CD8+
Campbell, D, Sanderson, S, SHASTRI, Nilabh   +2 more
core   +1 more source

Tumor-targeting peptides from combinatorial libraries [PDF]

Advanced Drug Delivery Reviews, 2017
Cancer is one of the major and leading causes of death worldwide. Two of the greatest challenges in fighting cancer are early detection and effective treatments with no or minimum side effects. Widespread use of targeted therapies and molecular imaging in clinics requires high affinity, tumor-specific agents as effective targeting vehicles to deliver ...
Liu, Ruiwu, Li, Xiaocen, Xiao, Wenwu, Lam, Kit S   +3 more
openaire   +4 more sources