Results 1 to 10 of about 133,954 (189)
Peptide nucleic acid-zirconium coordination nanoparticles [PDF]
Scientific Reports, 2023 Ideal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo
Özgür Öztürk +6 more
doaj +7 more sources
Visible Light-Induced Templated Metathesis of Peptide–Nucleic Acid Conjugates with a Diselenide Bridge [PDF]
Biomolecules, 2023 The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek +4 more
doaj +2 more sources
Peptide-nucleic acid nanostructures for transfection [PDF]
Biomolecular Concepts, 2012 To use nucleic acids in biomedical research and medical applications, these highly hydrophilic macromolecules have to be transported through the organism, targeted to specific cell surfaces, and have to cross cellular barriers.
Bechinger Burkhard
doaj +3 more sources
Cell-permeable peptide nucleic acid antisense oligonucleotide platform targeting human betacoronaviruses [PDF]
Frontiers in Microbiology, 2023 IntroductionAntisense oligonucleotides (ASOs) with therapeutic potential have recently been reported to target the SARS-CoV-2 genome. Peptide nucleic acids (PNAs)-based ASOs have been regarded as promising drug candidates, but intracellular delivery has ...
Soree Park +10 more
doaj +2 more sources
Peptide Nucleic Acid Microarrays [PDF]
, 2004 A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette Jacob +3 more
openalex +4 more sources
Detection of target DNA using fluorescent cationic polymer and peptide nucleic acid probes on solid support [PDF]
BMC Biotechnology, 2005 Background Nucleic acids detection using microarrays requires labelling of target nucleic acids with fluorophores or other reporter molecules prior to hybridization.
Leclerc Mario +7 more
doaj +2 more sources
Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design [PDF]
Advanced Science, 2022 Peptide nucleic acids (PNAs) are potential antisense therapies for genetic, acquired, and viral diseases. Efficiently selecting candidate PNA sequences for synthesis and evaluation from a genome containing hundreds to thousands of options can be ...
Chengxi Li +6 more
doaj +2 more sources
An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates [PDF]
Frontiers in Chemistry, 2022 Peptide-Peptide Nucleic Acid (PNA) conjugates targeting essential bacterial genes have shown significant potential in developing novel antisense antimicrobials. The majority of efforts in this area are focused on identifying different PNA targets and the
Nitin A. Patil +12 more
doaj +2 more sources
An Introduction to Peptide Nucleic Acid [PDF]
Current Issues in Molecular Biology, 1999 Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands. The unique chemical, physical and biological properties of PNA have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular ...
Nielsen, P E, Egholm, M
openaire +3 more sources
Applied Sciences, 2022 Peptide nucleic acid (PNA) is an analog of natural nucleic acids, where the sugar-phosphate backbone of DNA is replaced by an electrostatically neutral N-(2-aminoethyl)glycine backbone.
Yuichiro Aiba +2 more
doaj +1 more source