Peptide nucleic acid-zirconium coordination nanoparticles [PDF]
Scientific Reports, 2023 Ideal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo
Özgür Öztürk +6 more
doaj +2 more sources
Visible Light-Induced Templated Metathesis of Peptide–Nucleic Acid Conjugates with a Diselenide Bridge [PDF]
Biomolecules, 2023 The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek +4 more
doaj +2 more sources
Cell-permeable peptide nucleic acid antisense oligonucleotide platform targeting human betacoronaviruses [PDF]
Frontiers in Microbiology, 2023 IntroductionAntisense oligonucleotides (ASOs) with therapeutic potential have recently been reported to target the SARS-CoV-2 genome. Peptide nucleic acids (PNAs)-based ASOs have been regarded as promising drug candidates, but intracellular delivery has ...
Soree Park +10 more
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Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2). [PDF]
PLoS ONE, 2013 We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
Gabriel C Uguru +6 more
doaj +6 more sources
PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor [PDF]
Biosensors, 2016 A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli) 16S rRNA at 10 fM, which corresponds to ~100–1000 colony forming units/mL (CFU/mL) depending on cellular rRNA levels.
Leyla Esfandiari +7 more
doaj +3 more sources
Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design [PDF]
Advanced Science, 2022 Peptide nucleic acids (PNAs) are potential antisense therapies for genetic, acquired, and viral diseases. Efficiently selecting candidate PNA sequences for synthesis and evaluation from a genome containing hundreds to thousands of options can be ...
Chengxi Li +6 more
doaj +2 more sources
An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates [PDF]
Frontiers in Chemistry, 2022 Peptide-Peptide Nucleic Acid (PNA) conjugates targeting essential bacterial genes have shown significant potential in developing novel antisense antimicrobials. The majority of efforts in this area are focused on identifying different PNA targets and the
Nitin A. Patil +12 more
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Astrobiological implications of the stability and reactivity of peptide nucleic acid (PNA) in concentrated sulfuric acid. [PDF]
Sci AdvPetkowski JJ +9 more
europepmc +2 more sources
Recent Cutting-Edge Technologies for the Delivery of Peptide Nucleic Acid. [PDF]
ChemistryAvitabile C +4 more
europepmc +3 more sources
DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid. [PDF]
Cell Rep Phys Sci, 2023 Oyaghire SN +6 more
europepmc +2 more sources