Results 1 to 10 of about 133,556 (171)
Peptide nucleic acid-zirconium coordination nanoparticles. [PDF]
Sci Rep, 2023 AbstractIdeal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo molecules themselves.
Öztürk Ö +6 more
europepmc +7 more sources
Peptide Nucleic Acid Microarrays [PDF]
, 2004 A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette Jacob +3 more
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An Introduction to Peptide Nucleic Acid [PDF]
Current Issues in Molecular Biology, 1999 Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands. The unique chemical, physical and biological properties of PNA have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular ...
Nielsen, P E, Egholm, M
openaire +3 more sources
Peptide nucleic acids in materials science [PDF]
Artificial DNA: PNA & XNA, 2012 This review highlights the recent methods to prepare PNA-based materials through a combination of self-assembly and self-organization processes. The use of these methods allows easy and versatile preparation of structured hybrid materials showing specific recognition properties and unique physicochemical properties at the nano- and micro-scale levels ...
D. Bonifazi +3 more
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A self-replicating peptide nucleic acid [PDF]
Org. Biomol. Chem., 2014 This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
Günter von Kiedrowski +1 more
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The central dogma of biological homochirality: How does chiral information propagate in a prebiotic network? [PDF]
J. Chem. Phys. 159, 061102 (2023), 2023 Biological systems are homochiral, raising the question of how a racemic mixture of prebiotically synthesized biomolecules could attain a homochiral state at the network level. Based on our recent results, we aim to address a related question of how chiral information might have flowed in a prebiotic network. Utilizing the crystallization properties of
arxiv +1 more source
Peptides for nucleic acid delivery
Advanced Drug Delivery Reviews, 2016 Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells.
Kariem Ezzat +4 more
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CABS-dock web server for the flexible docking of peptides to proteins without prior knowledge of the binding site [PDF]
Nucleic Acids Research, 43 (W1): W419-W424, 2015, 2015 Protein-peptide interactions play a key role in cell functions. Their structural characterization, though challenging, is important for the discovery of new drugs. The CABS-dock web server provides an interface for modeling protein-peptide interactions using a highly efficient protocol for the flexible docking of peptides to proteins.
arxiv +1 more source
Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator [PDF]
Eleanor F Banwell, Bernard M A G Piette, Anne Taormina, Jonathan G
Heddle; Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator,
Molecular Biology and Evolution, msx292 (2017), 2017 Even the simplest organisms are too complex to have spontaneously arisen fully-formed, yet precursors to first life must have emerged ab initio from their environment. A watershed event was the appearance of the first entity capable of evolution: the Initial Darwinian Ancestor.
arxiv +1 more source
Synthesis and Purification of Peptide Nucleic Acids [PDF]
Current Protocols in Nucleic Acid Chemistry, 2002 AbstractPeptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A. +2 more
openaire +4 more sources