Peptide nucleic acid-zirconium coordination nanoparticles [PDF]
Scientific Reports, 2023 Ideal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo
Özgür Öztürk +6 more
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Detection of target DNA using fluorescent cationic polymer and peptide nucleic acid probes on solid support [PDF]
BMC Biotechnology, 2005 Background Nucleic acids detection using microarrays requires labelling of target nucleic acids with fluorophores or other reporter molecules prior to hybridization.
Leclerc Mario +7 more
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Visible Light-Induced Templated Metathesis of Peptide–Nucleic Acid Conjugates with a Diselenide Bridge [PDF]
Biomolecules, 2023 The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek +4 more
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Peptide-Based Nanoparticles for Therapeutic Nucleic Acid Delivery
Biomedicines, 2021 Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a patient.
Prisca Boisguérin +4 more
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Potential applications of peptide nucleic acid in biomedical domain
Engineering Reports, 2020 Peptide Nucleic Acid (PNA) are DNA/RNA synthetic analogs with 2‐([2‐aminoethyl] amino) acetic acid backbone. They partake unique antisense and antigene properties, just due to its inhibitory effect on transcription and translation; they also undergo ...
Kshitij RB Singh +2 more
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Cell-permeable peptide nucleic acid antisense oligonucleotide platform targeting human betacoronaviruses [PDF]
Frontiers in Microbiology, 2023 IntroductionAntisense oligonucleotides (ASOs) with therapeutic potential have recently been reported to target the SARS-CoV-2 genome. Peptide nucleic acids (PNAs)-based ASOs have been regarded as promising drug candidates, but intracellular delivery has ...
Soree Park +10 more
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Peptide-nucleic acid nanostructures for transfection [PDF]
Biomolecular Concepts, 2012 To use nucleic acids in biomedical research and medical applications, these highly hydrophilic macromolecules have to be transported through the organism, targeted to specific cell surfaces, and have to cross cellular barriers.
Bechinger Burkhard
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Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis
Molecules, 2017 The monitoring of DNA and RNA biomarkers freely circulating in the blood constitutes the basis of innovative cancer detection methods based on liquid biopsy.
Roberta D’Agata +2 more
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PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor [PDF]
Biosensors, 2016 A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli) 16S rRNA at 10 fM, which corresponds to ~100–1000 colony forming units/mL (CFU/mL) depending on cellular rRNA levels.
Leyla Esfandiari +7 more
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Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2). [PDF]
PLoS ONE, 2013 We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
Gabriel C Uguru +6 more
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