Results 1 to 10 of about 209,687 (95)
Modeling Peptide Nucleic Acid Binding Enthalpies Using MM-GBSA. [PDF]
J Phys Chem B, 2022 The binding enthalpies of peptide nucleic acid (PNA) homoduplexes were predicted using a molecular mechanics generalized Born surface area approach. Using the nucleic acid nearest-neighbor model, these were decomposed into sequence parameters which could
Goodman J +4 more
europepmc +2 more sources
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber +3 more
core +1 more source
A Review of Peptide Nucleic Acid [PDF]
, 2015 Peptide Nucleic Acid (PNA) is a nucleobase oligomer in which the whole backbone is mainly replaced by N-(2- aminoethyl) glycine units. PNA is considered as DNA with a neutral peptide backbone due to negative charged sugar–phosphate backbone.
Shafiquzzaman Siddiquee +2 more
core +1 more source
Controlled assembly of SNAP-PNA-fluorophore systems on DNA templates to produce fluorescence resonance energy transfer [PDF]
, 2014 The SNAP protein is a widely used self-labeling tag that can be used for tracking protein localization and trafficking in living systems. A model system providing controlled alignment of SNAP-tag units can provide a new way to study clustering of fusion ...
Gholami, Z, Hanley, Q
core +1 more source
, 2022 High-cost viral nucleic acid detection devices (e.g., qPCR system) are limited resources for developing counties and rural areas, leading to underdiagnosis or even pandemics of viral infectious diseases.
Wang Wan (1901359) +31 more
core +1 more source
DNA Encoded Biotechnologies for Informative Cancer Diagnostics [PDF]
, 2009 This thesis describes the development of DNA-encoded, multi-parametric, sensing platforms for informative cancer diagnostics. In the first part of this thesis, I will present a technology called “DNA-encoded antibody library (DEAL).” In this approach ...
Kwong, Gabriel Abner
core +1 more source
Automated Fast-Flow Synthesis of Peptide Nucleic Acid Conjugates
, 2021 Peptide nucleic acids (PNAs) are charge-neutral oligonucleotides with emerging potential for treatment of genetic, acquired, and viral diseases, including COVID-19. Their challenging synthesis, however, limits their use for rapid therapeutic intervention
Andrei, Loas +11 more
core +1 more source
Fluorinated peptide nucleic acid
, 2003 The fluorinated olefinic peptide nucleic acid analogue (F-OPA) monomer containing the base thymine was synthesised in 13 steps. PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting ...
Marcel Hollenstein +5 more
core +1 more source
Olefinic peptide nucleic acid (OPA)
, 2003 The olefinic peptide nucleic acid analogues (OPA) monomers containing the bases thymine and adenine were synthesised in 11 steps. Fully modified oligomers containing these units were prepared and their pairing properties assessed by means of UV-melting ...
Gautschi, Daniel, Leumann, Christian
core +1 more source
Exploring Artificial Nucleic Acid Mimicking Peptide Nanofibers
, 2023 Nucleic acids play key roles in Nature, including storage of genetic information and translation into a wide variety of proteins that collectively build up cells. Their intrinsic programmability can be utilized to bind specific targets for a wide variety
Albert C. Fahrenbach +23 more
core +2 more sources