Results 91 to 100 of about 200,834 (306)

Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA2DNA triplexes

Beilstein Journal of Organic Chemistry, 2014
Pyrene derivatives can be incorporated into nucleic acid analogs in order to obtain switchable probes or supramolecular architectures. In this paper, peptide nucleic acids (PNAs) containing 1 to 3 1-pyreneacetic acid units (PNA1–6) with a sequence with ...
Alex Manicardi, Lucia Guidi, Alice Ghidini, Roberto Corradini   +3 more
doaj   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry

Nature Communications
The RNA-peptide world hypothesis postulates the early co-evolution of RNA and peptides that led to the emergence of non-enzymatic RNA replication and peptide synthesis.
Karina K. Nakashima, Fatma Zohra Mihoubi, Jagandeep S. Saraya, Kieran O. Russell, Fidan Rahmatova, James D. Robinson, Maria Julia Maristany, Jan Huertas, Roger Rubio-Sánchez, Rosana Collepardo-Guevara, Derek K. O’Flaherty, Claudia Bonfio   +11 more
doaj   +1 more source

peptide nucleic acid

Citation: 'peptide nucleic acid' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09714 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Nucleic acid peptide nanogels for the treatment of bacterial keratitis

, 2020
Sybil Obuobi, Venkatesh Mayandi, Nurul Azlyn Mohd Nor, Benedict Jiasheng Lee, Rajamani Lakshminarayanan, Pui Lai Rachel Ee   +5 more
openalex   +2 more sources

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.

Тонкие химические технологии, 2007
Solid-phase Boc-protocol and synthetic strategy of negatively charged peptide nucleic acids has been suggested. New thymine containing negatively charged PNA decamer based on L-glutamic acid and glycine was synthesized.
N. P. Boyarskaya, Yu. G. Kirillova, D. S. Esipov, V. I. Shvets   +3 more
doaj  

Mitochondria‐Specific Protein Delivery by Protease‐Triggered Release in Plants with Single‐Walled Carbon Nanotubes

Advanced Materials Technologies, EarlyView.
Polymer‐coated carbon nanotubes were engineered as protease‐responsive nanocarriers for protein delivery in intact plants. GFP cargo can be released by cytosolic phytaspase cleavage and subsequently targeted to mitochondria via an N‐terminal sequence, enabling controlled intracellular protein delivery without tissue damage and demonstrating stable ...
Simon Sau Yin Law, Takehiro Suzuki, Tsuyohiko Fujigaya, Keiji Numata   +3 more
wiley   +1 more source

Design of the photosensitized peptide nucleic acids for the analysis of geno-typing [PDF]

, 2001
H. lkeda, Fumihiro Fujimori, Yasufumi Murakami, Y. Nakamura   +3 more
openalex   +1 more source