Results 91 to 100 of about 134,053 (282)
Targeted Delivery of Plasmid DNA to Myogenic Cells via Transferrin-Conjugated Peptide Nucleic Acid [PDF]
, 2000 Kenneth W. Liang +2 more
openalex +1 more source
An Efficient Synthetic Strategy for the Preparation of Nucleic Acid-Encoded Peptide and Protein Libraries for In Vitro Evolution Protocols [PDF]
, 2000 Markus Kurz, Guannan Kuang, Peter Lohse
openalex +2 more sources
Advanced Sensor Research, EarlyView.Tau protein plays a critical role in the pathology of Alzheimer's disease, utilizing extracellular vesicles (EVs) as a mechanism for intercellular transmission. This study develops a highly sensitive sandwich assay biosensor for detecting and quantifying tau‐associated EVs using surface‐enhanced Raman spectroscopy (SERS).
Saqer Al Abdullah +6 more
wiley +1 more source
Nitrogen heterocycles form peptide nucleic acid precursors in complex prebiotic mixtures
Scientific Reports, 2019 The ability to store information is believed to have been crucial for the origin and evolution of life; however, little is known about the genetic polymers relevant to abiogenesis.
Laura E. Rodriguez +4 more
doaj +1 more source
Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Advanced Therapeutics, EarlyView.This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar +7 more
wiley +1 more source
Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.
Тонкие химические технологии, 2007 Solid-phase Boc-protocol and synthetic strategy of negatively charged peptide nucleic acids has been suggested. New thymine containing negatively charged PNA decamer based on L-glutamic acid and glycine was synthesized.
N. P. Boyarskaya +3 more
doaj
Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
Advanced Science, EarlyView.This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang +14 more
wiley +1 more source
Control of electron transfer in DNA by peptide nucleic acids (PNA) [PDF]
, 2000 Kazuhito Tanabe +4 more
openalex +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source