Results 91 to 100 of about 134,053 (282)

A SERS‐Based Antibody‐Aptamer Sandwich Assay for Extracellular Vesicle‐Associated Tau Detection Using Gold Nanoparticles

open access: yesAdvanced Sensor Research, EarlyView.
Tau protein plays a critical role in the pathology of Alzheimer's disease, utilizing extracellular vesicles (EVs) as a mechanism for intercellular transmission. This study develops a highly sensitive sandwich assay biosensor for detecting and quantifying tau‐associated EVs using surface‐enhanced Raman spectroscopy (SERS).
Saqer Al Abdullah   +6 more
wiley   +1 more source

Nitrogen heterocycles form peptide nucleic acid precursors in complex prebiotic mixtures

open access: yesScientific Reports, 2019
The ability to store information is believed to have been crucial for the origin and evolution of life; however, little is known about the genetic polymers relevant to abiogenesis.
Laura E. Rodriguez   +4 more
doaj   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

open access: yesAdvanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar   +7 more
wiley   +1 more source

Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.

open access: yesТонкие химические технологии, 2007
Solid-phase Boc-protocol and synthetic strategy of negatively charged peptide nucleic acids has been suggested. New thymine containing negatively charged PNA decamer based on L-glutamic acid and glycine was synthesized.
N. P. Boyarskaya   +3 more
doaj  

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

open access: yesAdvanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang   +14 more
wiley   +1 more source

Control of electron transfer in DNA by peptide nucleic acids (PNA) [PDF]

open access: bronze, 2000
Kazuhito Tanabe   +4 more
openalex   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

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