Results 171 to 180 of about 200,834 (306)

Accurate Identification of Protein Binding Sites for All Drug Modalities Using ALLSites

Advanced Science, EarlyView.
ALLSites is a unified sequence‐based framework for identifying proteome‐wide binding sites across all drug modalities. It integrates a gated convolutional network with a transformer architecture to capture residue interactions directly from the sequence.
Minjie Mou, Mingkun Lu, Zhimeng Zhou, Yanlin Ren, Xinyuan Yu, Ziqi Pan, Yuan Zhou, Hao Yang, Lingyan Zheng, Shukai Gu, Yang Zhang, Wei Hu, Fengcheng Li, Haibin Dai, Feng Zhu   +14 more
wiley   +1 more source

Cell-Penetrating Anti-Sense Peptide Nucleic Acids Targeting Sulfatase 2 Inhibit Adipogenesis in Human Mesenchymal Stem Cells

Daram Jung, Sungjin Ahn, Yeasel Jeon, Minhee Kim, In Guk Park, Areum Kim, Minsoo Noh   +6 more
openalex   +1 more source

Topical Application of Peptide Nucleic Acid Antisense Oligonucleotide for MMP-1 and Its Potential Anti-Aging Properties. [PDF]

J Clin Med, 2023
Lee YI, Lee SG, Jung I, Suk J, Baeg C, Han SY, Seo JY, Jung D, Jeon Y, Lee JH.   +9 more
europepmc   +1 more source

Multifunctional Gelatin‐Based Smart Films Integrating Thermochromic Encryption, Temperature‐Regulated Photothermal Management, Reprocessability, and Biodegradability for Sustainable Applications

Advanced Science, EarlyView.
Multifunctional gelatin films synergizing thermochromic encryption, self‐regulating photothermal management, and closed‐loop recyclability offer sustainable solutions for intelligent packaging. ABSTRACT Multifunctional gelatin‐based smart films are engineered by incorporating hyperbranched polyglycerol (HBPG) as a plasticizer, dialdehyde β‐cyclodextrin
Yuehong Zhang, Chen Yang, Langlang Dai, Leipeng Liu, Vijay Kumar Thakur   +4 more
wiley   +1 more source

Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups. [PDF]

Angew Chem Int Ed Engl
Gless BH, Jones E, Labão-Almeida C, Tang C, Gottscheber N, Couto R, Bernardes GJL.   +6 more
europepmc   +1 more source

Using Peptide Nucleic Acid Hybridization Probes for Qualitative and Quantitative Analysis of Nucleic Acid Therapeutics by Capillary Electrophoresis. [PDF]

Anal Chem, 2023
Hutanu A, Signori C, Moritz B, Gregoritza M, Rohde A, Schwarz MA.   +5 more
europepmc   +1 more source

Highly efficient strand invasion by peptide nucleic acid bearing optically pure lysine residues in its backbone [PDF]

, 2006
Yoji Yamamoto, Junya Yoshida, Tullia Tedeschi, Roberto Corradini, Stefano Sforza, Makoto Komiyama   +5 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Targeting <i>carA</i> Using Optimized Antisense Peptide Nucleic Acid-Cell-Penetrating Peptide Conjugates in <i>Acinetobacter baumannii</i>: A Novel Antibacterial Approach. [PDF]

Int J Mol Sci
Seo JH, Kim YJ, Jeon WJ, Yoo JS, Moon DC.   +4 more
europepmc   +1 more source

Development of a Novel Peptide Nucleic Acid Probe for the Detection of Legionella spp. in Water Samples. [PDF]

Microorganisms, 2022
Nácher-Vázquez M, Barbosa A, Armelim I, Azevedo AS, Almeida GN, Pizarro C, Azevedo NF, Almeida C, Cerqueira L.   +8 more
europepmc   +1 more source