Results 101 to 110 of about 517,349 (290)
Advanced Science, EarlyView.A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen +14 more
wiley +1 more source
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification [PDF]
, 2008 *Motivation:* In current proteome research, peptide sequencing is probably the most widely used method for protein mixture identification. However, this peptide-centric method has its own disadvantages such as the immense volume of tandem Mass ...
Zengyou He +5 more
core
Standards in Genomic Sciences, 2018 Members of the genus Cylindrospermopsis represent an important environmental and health concern. Strains CS-508 and MVCC14 of C. raciborskii were isolated from freshwater reservoirs located in Australia and Uruguay, respectively.
Juan J Fuentes-Valdés +7 more
doaj +1 more source
Advanced Science, EarlyView.This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source
Characterisation of the anti-inflammatory and anti-proliferative effects of natriuretic peptides in rodents. [PDF]
, 2007 Natriuretic peptides are a family of vasoactive hormones that play important roles in cardiovascular homeostasis. These peptides exert biological effects primarily via activation of guanylate cyclase (GC)-coupled natriuretic peptide receptors (NPR) that ...
Panayiotou, C.M.
core
Crystal structure of the condensation domain from lovastatin polyketide synthase
Synthetic and Systems Biotechnology, 2019 The highly reducing iterative polyketide synthases responsible for lovastatin biosynthesis contains a section homologous to condensation (CON) domain observed in nonribosomal peptide synthetases (NRPSs).
Lei Wang, Meijuan Yuan, Jianting Zheng
doaj +1 more source
Advanced Science, EarlyView.A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang +12 more
wiley +1 more source
Advanced Science, EarlyView.Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong +8 more
wiley +1 more source
Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity [PDF]
, 2006 Background: MHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide
Hattotuwagama, C.K. +14 more
core +1 more source
Recovering Genomics Clusters of Secondary Metabolites from Lakes Using Genome-Resolved Metagenomics
Frontiers in Microbiology, 2018 Metagenomic approaches became increasingly popular in the past decades due to decreasing costs of DNA sequencing and bioinformatics development. So far, however, the recovery of long genes coding for secondary metabolites still represents a big challenge.
Rafael R. C. Cuadrat +6 more
doaj +1 more source