Results 221 to 230 of about 38,957 (260)

Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide

Nitric Oxide, 2003
There is increasing evidence for biological functions of human C-peptide. Recently, we have described that proinsulin C-peptide increases nutritive capillary blood flow and restores erythrocyte deformability in type 1 diabetic patients, whereas it has no such effect in non-diabetic subjects.
Thomas, Wallerath, Thomas, Kunt, Thomas, Forst, Ellen I, Closs, Ralf, Lehmann, Thomas, Flohr, Matthias, Gabriel, Dirk, Schäfer, Andrea, Göpfert, Andreas, Pfützner, Jürgen, Beyer, Ulrich, Förstermann   +11 more
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Evolution and Taxonomic Distribution of Nonribosomal Peptide and Polyketide Synthases

Future Microbiology, 2008
The majority of nonribosomal peptide synthases and type I polyketide synthases are multimodular megasynthases of oligopeptide and polyketide secondary metabolites, respectively. Owing to their multimodular architecture, they synthesize their metabolites in assembly line logic.
Grigoris D, Amoutzias, Yves, Van de Peer, Dimitris, Mossialos   +2 more
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Nitration of a peptide phytotoxin by bacterial nitric oxide synthase

Nature, 2004
Nitric oxide (NO) is a potent intercellular signal in mammals that mediates key aspects of blood pressure, hormone release, nerve transmission and the immune response of higher organisms. Proteins homologous to full-length mammalian nitric oxide synthases (NOSs) are found in lower multicellular organisms. Recently, genome sequencing has shown that some
Johan A, Kers, Michael J, Wach, Stuart B, Krasnoff, Joanne, Widom, Kimberly D, Cameron, Raghida A, Bukhalid, Donna M, Gibson, Brian R, Crane, Rosemary, Loria   +8 more
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Target Recognition of Apocalmodulin by Nitric Oxide Synthase I Peptides

Biochemistry, 2002
An increasing number of proteins are found that are regulated by the Ca(2+)-free state of calmodulin, apocalmodulin. Many of these targets harbor a so-called IQ motif within their primary sequence, but several target proteins of apocalmodulin lack this motif.
Petra, Censarek, Michael, Beyermann, Karl-Wilhelm, Koch   +2 more
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Insect venom peptides as potent inhibitors of Escherichia coli ATP synthase

International Journal of Biological Macromolecules, 2020
Insect venom peptides (IVPs) eumenitin, lasiocepsin, lycosin1, mastoparanB, panurgine1, and protonectin possess antibacterial properties, and the ubiquitous enzyme ATP synthase has a peptide-binding site. In the present study, we studied the effect of IVPs on binding and inhibition of three Escherichia coli strains (wild type, mutant, and null) and ...
Amon, Amini, Samah, Raheem, Amanda, Steiner, Farah, Deeba, Zulfiqar, Ahmad   +4 more
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Phytochelatin synthase: of a protease a peptide polymerase made

Physiologia Plantarum, 2012
Of the mechanisms known to protect vascular plants and some algae, fungi and invertebrates from the toxic effects of non‐essential heavy metals such as As, Cd or Hg, one of the most sophisticated is the enzyme‐catalyzed synthesis of phytochelatins (PCs).
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Discovering Peptide Inhibitors of Human Squalene Synthase Through Screening the Phage-Displayed Cyclic Peptide c7c Library

Applied Biochemistry and Biotechnology, 2016
Many drugs for the treatment of hypercholesterolemia are targeting the enzymes involved in human cholesterol biosynthesis pathway. Squalene synthase, the rate-limiting enzyme located at the downstream of cholesterol synthesis pathway, has become a better candidate to develop next-generation hypocholesterolemia drugs. In the present study, we cloned and
David, Shiuan, Yue-Hao, Chen, Hwan-Kang, Lin, Kao-Jean, Huang, Da-Fu, Tai, Ding-Kwo, Chang   +5 more
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Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides

2023
Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational modification chemistries1, 2. However, RiPPs are rarely reported as hybrid molecules incorporating biosynthetic machineries from other natural product families3–8.
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Haiyang Cui, Shravan R. Dommaraju, Douglas A. Mitchell, Huimin Zhao   +6 more
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Venom peptides as selective inhibitors of bacterial ATP synthase

The FASEB Journal, 2020
Background It is predicted that by the year 2050 world will face 10 million additional deaths per year due to antibiotic resistance. Misuse and overuse of antibiotics, is making microbes resistant to normally effective antibiotics.
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The identification of thymidylate synthase peptide domains located in the interface region that bind thymidylate synthase mRNA

Biochemical and Biophysical Research Communications, 2002
Thymidylate synthase (TS) is a critical chemotherapeutic target and intracellular levels of TS are an important determinant of sensitivity to TS inhibitors. Translational autoregulation represents one cellular mechanism for controlling the level of expression of TS. This mechanism involves the binding of TS protein to its own messenger RNA (mRNA), thus,
Donna M, Voeller, Maria, Zajac-Kaye, Robert J, Fisher, Carmen J, Allegra   +3 more
openaire   +2 more sources