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Applied Biochemistry and Biotechnology, 2016
Many drugs for the treatment of hypercholesterolemia are targeting the enzymes involved in human cholesterol biosynthesis pathway. Squalene synthase, the rate-limiting enzyme located at the downstream of cholesterol synthesis pathway, has become a better candidate to develop next-generation hypocholesterolemia drugs. In the present study, we cloned and
David, Shiuan +5 more
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Many drugs for the treatment of hypercholesterolemia are targeting the enzymes involved in human cholesterol biosynthesis pathway. Squalene synthase, the rate-limiting enzyme located at the downstream of cholesterol synthesis pathway, has become a better candidate to develop next-generation hypocholesterolemia drugs. In the present study, we cloned and
David, Shiuan +5 more
openaire +2 more sources
Insight into the Bind−Lock Mechanism of the Yeast Mitochondrial ATP Synthase Inhibitory Peptide
Biochemistry, 2007The mechanism of yeast mitochondrial F1-ATPase inhibition by its regulatory peptide IF1 was investigated with the noncatalytic sites frozen by pyrophosphate pretreatment that mimics filling by ATP. This allowed for confirmation of the mismatch between catalytic site occupancy and IF1 binding rate without the kinetic restriction due to slow ATP binding ...
Corvest, V., Sigalat, C., Haraux, F.
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Assembly of aryl‐capped siderophores by modular peptide synthetases and polyketide synthases
Molecular Microbiology, 2000Bacterial siderophores assist pathogens in iron acquisition inside their hosts. They are often essential for achieving a successful infection, and their biosynthesis represents an attractive antibiotic target. Recently, several siderophore biosynthetic loci have been identified, and in vitro studies have advanced our knowledge of the biosynthesis of ...
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THYMIDYLATE SYNTHASE RELATED POLYEPITOPE PEPTIDE CANCER THERAPEUTICS
2005VACCINO PEPTIDICO ANTITIMIDILATO SINTASI PER LA TERAPIA DI NEOPLASIE MALIGNE PRODUCENTI ...
P. CORREALE +3 more
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A bind-lock mechanism for the inhibitory peptide of mitochondrial ATP synthase
2006xxx
Corvestv, (corvest +7 more
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Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics
Natural Product Reports, 2007Stefano Donadio, Margherita Sosio
exaly