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Cyclodipeptide synthases are a family of tRNA-dependent peptide bond–forming enzymes
Nature Chemical Biology, 2009Cyclodipeptides and their derivatives belong to the diketopiperazine (DKP) family, which is comprised of a broad array of natural products that exhibit useful biological properties. In the few known DKP biosynthetic pathways, nonribosomal peptide synthetases (NRPSs) are involved in the synthesis of cyclodipeptides that constitute the DKP scaffold ...
Gondry, Muriel +16 more
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A Novel Peptide Inhibits Induction of Nitric Oxide Synthase
1996Alpha-melanocyte stimulating hormone has been shown to prevent endotoxin shock. A heptapeptide analog (HPA) has recently been synthesized and shown to be an even more potent protective agent. Since the hypotensive and toxic actions of endotoxin lipopolysaccharide (LPS) appear to involve the induction of nitric oxide synthase, we have examined the ...
G. Abou-Mohamed +2 more
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Use of a Synthetic Peptide as a Selective Substrate for Glycogen Synthase Kinase 3
Analytical Biochemistry, 1994Glycogen synthase kinase 3 (GSK-3) is involved in the regulation of several metabolic enzymes and transcription factors in response to extracellular signals. Here we report the use of a synthetic peptide derived from the sequence of the cyclic AMP responsive element binding protein (CREB) as a specific substrate for GSK-3 isoforms.
Q M, Wang, P J, Roach, C J, Fiol
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Inhibition of nitric oxide synthase with calmodulin binding peptides
2005The constitutive isoforms of nitric oxide synthase (nNOS and eNOS) are regulated by calmodulin, which adopts an active conformation upon binding calcium and binds to target proteins. The inducible isoform of NOS (iNOS) copurifies with calmodulin [1] and was reported not to require calcium for activation [2].
Karen S. Gregson +2 more
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Assembly of aryl‐capped siderophores by modular peptide synthetases and polyketide synthases
Molecular Microbiology, 2000Bacterial siderophores assist pathogens in iron acquisition inside their hosts. They are often essential for achieving a successful infection, and their biosynthesis represents an attractive antibiotic target. Recently, several siderophore biosynthetic loci have been identified, and in vitro studies have advanced our knowledge of the biosynthesis of ...
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Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics
Natural Product Reports, 2007Stefano Donadio, Margherita Sosio
exaly