Results 221 to 230 of about 20,368 (260)

Post-translational modification of polyketide and nonribosomal peptide synthases

Current Opinion in Chemical Biology, 1997
The past year has witnessed a major advance in the study of polyketide and nonribosomal peptide biosynthesis with the identification of the phosphopantetheinyl transferase enzyme family, enzymes required to produce active, post-translationally modified polyketide and peptide synthases.
Christopher Walsh, Paul Weinreb, Amy M Gehring   +2 more
exaly   +3 more sources

Evolution and Taxonomic Distribution of Nonribosomal Peptide and Polyketide Synthases

Future Microbiology, 2008
The majority of nonribosomal peptide synthases and type I polyketide synthases are multimodular megasynthases of oligopeptide and polyketide secondary metabolites, respectively. Owing to their multimodular architecture, they synthesize their metabolites in assembly line logic.
Dimitris Mossialos, Yves Van De Peer
exaly   +3 more sources

Biosynthesis of Tetronates by a Nonribosomal Peptide Synthetase–Polyketide Synthase System

Organic Letters, 2023
A cryptic tetronate biosynthetic pathway was identified in Kitasatospora niigatensis DSM 44781 via heterologous expression. Distinct from the currently known biosynthetic pathways, this system utilizes a partially functional nonribosomal peptide synthetase and a broadly selective polyketide synthase to direct the assembly and lactonization of the ...
Wenya Tian, Xinru Chen, Jun Zhang, Mengmeng Zheng, Guangzheng Wei, Zixin Deng, Xudong Qu   +6 more
openaire   +2 more sources

Nitration of a peptide phytotoxin by bacterial nitric oxide synthase

Nature, 2004
Nitric oxide (NO) is a potent intercellular signal in mammals that mediates key aspects of blood pressure, hormone release, nerve transmission and the immune response of higher organisms. Proteins homologous to full-length mammalian nitric oxide synthases (NOSs) are found in lower multicellular organisms. Recently, genome sequencing has shown that some
Johan A, Kers, Michael J, Wach, Stuart B, Krasnoff, Joanne, Widom, Kimberly D, Cameron, Raghida A, Bukhalid, Donna M, Gibson, Brian R, Crane, Rosemary, Loria   +8 more
openaire   +2 more sources

From Peptide Precursors to Oxazole and Thiazole-Containing Peptide Antibiotics: Microcin B17 Synthase

Science, 1996
Esherichia coli microcin B17 is a posttranslationally modified peptide that inhibits bacterial DNA gyrase. It contains four oxazole and four thiazole rings and is representative of a broad class of pharmaceutically important natural products with five-membered heterocycles derived from peptide precursors.
Y M, Li, J C, Milne, L L, Madison, R, Kolter, C T, Walsh   +4 more
openaire   +2 more sources

Combinatorialization of Fungal Polyketide Synthase–Peptide Synthetase Hybrid Proteins

Journal of the American Chemical Society, 2014
The programming of the fungal polyketide synthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products. An additional level of complexity has been found within PKS-based pathways where the PKS is fused to a single module nonribosomal peptide synthetase (NRPS) to synthesize polyketides conjugated to amino acids.
Thomas B, Kakule, Zhenjian, Lin, Eric W, Schmidt   +2 more
openaire   +2 more sources

Target Recognition of Apocalmodulin by Nitric Oxide Synthase I Peptides

Biochemistry, 2002
An increasing number of proteins are found that are regulated by the Ca(2+)-free state of calmodulin, apocalmodulin. Many of these targets harbor a so-called IQ motif within their primary sequence, but several target proteins of apocalmodulin lack this motif.
Petra, Censarek, Michael, Beyermann, Karl-Wilhelm, Koch   +2 more
openaire   +2 more sources

Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide

Nitric Oxide, 2003
There is increasing evidence for biological functions of human C-peptide. Recently, we have described that proinsulin C-peptide increases nutritive capillary blood flow and restores erythrocyte deformability in type 1 diabetic patients, whereas it has no such effect in non-diabetic subjects.
Thomas, Wallerath, Thomas, Kunt, Thomas, Forst, Ellen I, Closs, Ralf, Lehmann, Thomas, Flohr, Matthias, Gabriel, Dirk, Schäfer, Andrea, Göpfert, Andreas, Pfützner, Jürgen, Beyer, Ulrich, Förstermann   +11 more
openaire   +2 more sources

Phytochelatin synthase: of a protease a peptide polymerase made

Physiologia Plantarum, 2012
Of the mechanisms known to protect vascular plants and some algae, fungi and invertebrates from the toxic effects of non‐essential heavy metals such as As, Cd or Hg, one of the most sophisticated is the enzyme‐catalyzed synthesis of phytochelatins (PCs).
openaire   +2 more sources

The ATP Synthase ofTrypanosoma bruceiIs Developmentally Regulated by an Inhibitor Peptide

Archives of Biochemistry and Biophysics, 1996
The Trypanosoma brucei ATP synthase, like those of other organisms, is composed of two moieties, the membrane bound F0 and the catalytic F1 with each of these parts comprised of multiple subunits. In addition, an endogenous inhibitor peptide of the ATP synthase has been identified from a variety of sources.
T B, Chi, S Y, Choi, N, Williams
openaire   +2 more sources