Results 81 to 90 of about 11,450 (169)

Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Jibon Kumar Paul, Arzuba Akter, Nurnabi Azad Jewel, Mohimenul Haque Rolin, Daniyal Karim, Raphael Kabir Niloy, Shakhinur Islam Mondal   +6 more
wiley   +1 more source

From discovery to potential application: engineering a novel M23 peptidase to combat Listeria monocytogenes

Scientific Reports
Peptidoglycan hydrolases are promising alternatives for combating pathogens due to their specificity and potent bacteriolytic activity. In this study, a novel M23 peptidase from Streptococcus thermophilus NCTC10353, designated StM23, was discovered and ...
Magdalena Kaus-Drobek, Marzena Nowacka, Magdalena Gewartowska, Małgorzata Korzeniowska nee Wiweger, Merete Rusås Jensen, Trond Møretrø, Even Heir, Elżbieta Nowak, Izabela Sabała   +8 more
doaj   +1 more source

Comprehensive analysis of peptidoglycan hydrolases in Caulobacter crescentus

, 2016
The peptidoglycan (PG) sacculus is a large macromolecule enclosing most bacterial cells. During progression of the cell cycle, it needs to be continuously remodelled to enable elongation of the cell body and, finally, cell division.
Zielinska, Aleksandra, Thanbichler, Martin (Prof. Dr.)   +1 more
openaire   +3 more sources

Reduced peptidoglycan synthesis capacity impairs growth of E. coli at high salt concentration

mBio
Gram-negative bacteria have a thin peptidoglycan layer between the cytoplasmic and outer membranes protecting the cell from osmotic challenges. Hydrolases of this structure are needed to cleave bonds to allow the newly synthesized peptidoglycan strands ...
Dema Alodaini, Victor Hernandez-Rocamora, Gabriela Boelter, Xuyu Ma, Micheal B. Alao, Hannah M. Doherty, Jack A. Bryant, Patrick Moynihan, Danesh Moradigaravand, Monika Glinkowska, Waldemar Vollmer, Manuel Banzhaf   +11 more
doaj   +1 more source

Phenotypic and genotypic characterization of peptidoglycan hydrolases of Lactobacillus sakei

Journal of Advanced Research, 2016
Lactobacillus sakei, a lactic acid bacterium naturally found in fresh meat and sea products, is considered to be one of the most important bacterial species involved in meat fermentation and bio-preservation. Several enzymes of Lb. sakei species contributing to microbial safeguarding and organoleptic properties of fermented-meat were studied.
Najjari, Afef, Amairi, Houda, Chaillou, Stephane, Mora, Diego, Boudabous, Abdellatif, Zagorec, Monique, Ouzari, Hadda   +6 more
openaire   +7 more sources

Nucleotide Sequence of Conjugative Prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes

Frontiers in Microbiology, 2014
Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide efflux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3
Francesco eIannelli, Maria eSantagati, Francesco eSantoro, Marco R Oggioni, Stefania eStefani, Gianni ePozzi   +5 more
doaj   +1 more source

SpyB, a small heme-binding protein, affects the composition of the cell wall in Streptococcus pyogenes

Frontiers in Cellular and Infection Microbiology, 2016
Streptococcus pyogenes (Group A Streptococcus or GAS) is a haemolytic human pathogen associated with a wide variety of infections ranging from minor skin and throat infections to life-threatening invasive diseases.
Rebecca J Edgar, Jing Chen, Sashi Kant, Elena Rechkina, Jeffrey S Rush, Lennart Scott Forsberg, Bernhard Jaehrig, Parastoo Azadi, Veronika Tchesnokova, Evgeni V Sokurenko, Haining Zhu, Konstantin V Korotkov, Vijay Pancholi, Natalia Korotkova   +13 more
doaj   +1 more source

Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis.

PLoS Pathogens, 2017
Enterococcus faecalis is an opportunistic pathogen frequently isolated in clinical settings. This organism is intrinsically resistant to several clinically relevant antibiotics and can transfer resistance to other pathogens. Although E.
Bartłomiej Salamaga, Tomasz K Prajsnar, Ana Jareño-Martinez, Joost Willemse, Martin A Bewley, Françoise Chau, Tassadit Ben Belkacem, Annemarie H Meijer, David H Dockrell, Stephen A Renshaw, Stéphane Mesnage   +10 more
doaj   +1 more source

A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in Pseudomonas aeruginosa

mBio, 2018
Carboxy-terminal processing proteases (CTPs) occur in all three domains of life. In bacteria, some of them have been associated with virulence. However, the precise roles of bacterial CTPs are poorly understood, and few direct proteolytic substrates have
Disha Srivastava, Jin Seo, Binayak Rimal, Sung Joon Kim, Stephanie Zhen, Andrew J. Darwin   +5 more
doaj   +1 more source

Surface display of heterologous proteins in Bacillus thuringiensis using a peptidoglycan hydrolase anchor

Microbial Cell Factories, 2009
Background Previous studies have revealed that the lysin motif (LysM) domains of bacterial cell wall-degrading enzymes are able to bind to peptidoglycan moieties of the cell wall.
Cai Hao, Yu Ziniu, Jiang Mengtian, Shao Xiaohu, Li Lin   +4 more
doaj   +1 more source