Results 111 to 120 of about 87,420 (248)

Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system

eLife, 2014
Bacteria have to avoid recognition by the host immune system in order to establish a successful infection. Peptidoglycan, the principal constituent of virtually all bacterial surfaces, is a specific molecular signature recognized by dedicated host ...
Magda Luciana Atilano, Pedro Matos Pereira, Filipa Vaz, Maria João Catalão, Patricia Reed, Inês Ramos Grilo, Rita Gonçalves Sobral, Petros Ligoxygakis, Mariana Gomes Pinho, Sérgio Raposo Filipe   +9 more
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, Volume 599, Issue 12, Page 1634-1648, June 2025.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Anchoring of proteins to lactic acid bacteria [PDF]

, 1999
The anchoring of proteins to the cell surface of lactic acid bacteria (LAB) using genetic techniques is an exciting and emerging research area that holds great promise for a wide variety of biotechnological applications. This paper reviews five different
A Hoick, A Mercenier, A Robert, A Strauss, A Strauss, AJ Haandrikman, AP Pugsley, C Andréoni, CBM Maassen, CM Franke, CM Franke, CM Rush, D Medaglini, D Medaglini, D Medaglini, E Gunneriusson, FO Eko, G Buist, G Buist, G Georgiou, G Pozzi, G Pozzi, G Pozzi, G Pozzi, G Pozzi, G Vidgrén, H Ton-That, H Ton-That, HJ Boot, I Poquet, J Kok, JC Piard, JM Wells, K Robinson, L Steidler, M, M Hansson, M Hofnung, ML Callegari, MR Oggioni, MR Oggioni, O Schneewind, O Schneewind, O Schneewind, P Samuelson, P Vos, PH Pouwels, PH Pouwels, PM Norton, PM Norton, RJ Leer, S Fabio, S Liljeqvist, S Ricci, S Stahl, S Tynkkynen, SC Cebolla, T Toba, TN Nguyen, TN Nguyen, UB Sleytr, VA Fischetti, VA Fischetti, VA Fischetti, WW Navarre, WW Navarre, WW Navarre   +66 more
core   +1 more source

Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD)

Comprehensive Physiology, Volume 15, Issue 3, June 2025.
Dissecting the pathophysiological role of Leukotrienes in the lung–gut axis: A potential mediator of the asthma–IBD crosstalk. ABSTRACT Leukotrienes are potent inflammatory lipid mediators produced primarily by immune cells. Inflammation, being the center stone of two major disease conditions, namely, asthma and inflammatory bowel disease (IBD), has ...
Emma Elizabeth Sabu Kattuman, Lakshminarayan Reddy Teegala, Somayeh Darzi, Charles K. Thodeti, Sailaja Paruchuri   +4 more
wiley   +1 more source

Bacteriophage endolysins as a response to emerging foodborne pathogens [PDF]

, 2012
Continuous reports on foodborne outbreaks and increasing prevalence of antibiotic-resistant bacteria call for the development of novel preservation techniques that assure the safety of food products.
Azeredo, Joana, Kluskens, Leon, Lavigne, Rob, Oliveira, Hugo Alexandre Mendes   +3 more
core   +1 more source

Skin microbiome engineering: Challenges and opportunities in skin diseases treatment

iMetaOmics, Volume 2, Issue 2, June 2025.
The skin microbiome plays a crucial role in skin health, influencing barrier integrity, immune responses, and disease susceptibility. Various interventions can reshape the microbiome, broadly categorized into targeted and untargeted approaches. Targeted strategies, such as phage therapy, engineered bacteria, and phage lysins, selectively modulate ...
Yiang Lyu, Juntao Shen, You Che, Lei Dai
wiley   +1 more source

A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens [PDF]

Science, 2016
The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient to protect Caenorhabditis elegans
Kavita J. Rangan, Howard C. Hang, Virginia A. Pedicord, Byungchul Kim, Yen Chih Wang, Yun Lu, Shai Shaham, Daniel Mucida   +7 more
openaire   +3 more sources

Comparative Genome Analysis of Three Halobacillus Strains Isolated From Saline Environments Reveal Potential Salt Tolerance and Algicidal Mechanisms

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
Following the previous complete genome analysis, this research provides the function of new Halobacillus species. Three strains were identified: Halobacillus shinanisalinarum sp. nov. SSTM10‐2T, Halobacillus salinarum sp. nov. SSBR10‐3T, and Halobacillus amylolyticus sp. nov. SSHM10‐5T.
Saru Gurung, Chang‐Muk Lee, Hang‐Yeon Weon, So‐Ra Han, Tae‐Jin Oh   +4 more
wiley   +1 more source

Acd, a peptidoglycan hydrolase of Clostridium difficile with N-acetylglucosaminidase activity [PDF]

Microbiology, 2005
A gene encoding a putative peptidoglycan hydrolase was identified by sequence similarity searching in the Clostridium difficile 630 genome sequence, and the corresponding protein, named Acd (autolysin of C. difficile) was expressed in Escherichia coli. The deduced amino acid sequence of Acd shows a modular structure with two main domains: an N-terminal
Anne Dhalluin, Ingrid Bourgeois, Martine Pestel‐Caron, Émilie Camiade, Grégory Raux, Pascal Courtin, Marie‐Pierre Chapot‐Chartier, Jean-Louis Pons   +7 more
openalex   +4 more sources

Binding Mechanism of the Peptidoglycan Hydrolase Acm2: Low Affinity, Broad Specificity [PDF]

Biophysical Journal, 2013
Peptidoglycan hydrolases are bacterial secreted enzymes that cleave covalent bonds in the cell-wall peptidoglycan, thereby fulfilling major physiological functions during cell growth and division. Although the molecular structure and functional roles of these enzymes have been widely studied, the molecular details underlying their interaction with ...
Pascal Hols, Marie-Clémence Duchêne, Thomas Rolain, Audrey Beaussart, Guillaume Andre, Yves F. Dufrêne, Sofiane El-Kirat-Chatel   +6 more
openaire   +3 more sources