Results 211 to 220 of about 26,717 (273)

Peptidomimetic Wet-Adhesive PEGtides with Synergistic and Multimodal Hydrogen Bonding

Journal of the American Chemical Society, 2022
The remarkable underwater adhesion of mussel foot proteins has long been an inspiration in the design of peptidomimetic materials. Although the synergistic wet adhesion of catechol and lysine has been recently highlighted, the critical role of the ...
Minseong Kim, Jinwoo Park, Eeseul Shin
exaly   +2 more sources

Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity

Journal of the American Chemical Society, 2021
An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is associated with Alzheimer's disease. A supramolecular strategy based on the assembly of peptidomimetic agents into functional vesicles has been conceived for the ...
Debabrata Maity, Mazin Magzoub, Andrew D Hamilton   +2 more
exaly   +2 more sources

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability

Journal of Medicinal Chemistry, 2021
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses.
Bing Bai, Alexandr Belovodskiy, Mostofa A Hena, Appan Srinivas Kandadai, Michael A. Joyce, H. Saffran, Justin A Shields, Muhammad Bashir Khan, E. Arutyunova, Jimmy Lu, Sardeev K Bajwa, D. Hockman, Conrad Fischer, Tess Lamer, Wayne Vuong, M. J. van Belkum, Z. Gu, F. Lin, Yanhua Du, Jia Xu, M. Rahim, H. Young, J. Vederas, D. Tyrrell, M. J. Lemieux, J. Nieman   +25 more
semanticscholar   +1 more source

Peptidomimetic therapeutics: scientific approaches and opportunities

Drug Discovery Today, 2017
Nir Qvit, Daria Mochly-Rosen
exaly   +2 more sources

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

Nature, 2019
Maik Müller, Milon Mondal, Alessandra Vitale   +2 more
exaly   +2 more sources

Peptidomimetics in Silico

Molecular Informatics, 2020
AbstractEndogenous peptides as part of physiological processes are targets of interest when it comes to finding desirable therapeutics which are able to modulate molecular interactions. The major limits presented by peptides when they are used as drugs have motivated the research of the synthesis of peptidomimetics obtained through chemical ...
Cristina Tomasella, Matteo Floris, Salvatore Guccione, Matteo Pappalardo, and Livia Basile   +4 more
openaire   +2 more sources

Peptidomimetic design

Current Opinion in Chemical Biology, 1998
Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease ...
A S, Ripka, D H, Rich
openaire   +2 more sources

Discovery of novel peptidomimetic boronate ClpP inhibitors with noncanonical enzyme mechanism as potent virulence blockers in vitro and in vivo.

Journal of Medicinal Chemistry, 2020
Caseinolytic protease P (ClpP) is considered as a promising target for the treatment of Staphylococcus aureus infections. In an unbiased screen of 2632 molecules, a peptidomimetic boronate, MLN9708, was found to be a potent suppressor of SaClpP function.
Y. Ju, Lihui He, Yuanzheng Zhou, Tao Yang, Ke Sun, Rao Song, Yang Yang, Chengwei Li, Zitai Sang, R. Bao, Youfu Luo   +10 more
semanticscholar   +1 more source

Peptidomimetics and Angiogenesis

Mini-Reviews in Medicinal Chemistry, 2002
Angiogenesis is the sprouting of new blood capillaries from surrounding preexisting blood vessels. This process is fundamental for embryonic development, wound healing and inflammation. In healthy adults angiogenesis is of minor importance. However, aberrant angiogenesis is essentially involved in disorders as diabetic retinopathy, rheumatoid arthritis
Ralph, Mazitschek, Patrick, Baumhof, Athanassios, Giannis   +2 more
openaire   +2 more sources

Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper

Journal of the American Chemical Society, 2018
Peng Teng, Zheng Niu, Fengyu She
exaly   +2 more sources