Results 131 to 140 of about 10,137 (233)

Retro Hydrazino-azapeptoids as Peptidomimetics of Proteasome Inhibitors

, 2016
Several groups of proteasome inhibitors are widely used to study the role of the ubiquin proteasome pathway in various cellular processes or as anticancer drugs. Peptidomimetics have been developed to circumvent problems inherent in peptides such as poor
Michèle Baudy-Floc'h (301048), Sandrine Aubin (2695684), Yannick Arlot-Bonnemains (415045), Bénédicte Martin (2441965), Jean-Guy Delcros (421326)   +4 more
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Peptidomimetics- Propargylamide-Based Isosteres of Peptide Structures

, 2018
Wünsch M. Peptidomimetics- Propargylamide-Based Isosteres of Peptide Structures. Bielefeld: Universität Bielefeld; 2018.In medicinal chemistry, the importance of peptidomimetics as small-molecular, orally bioavailable PPI disruptors increases with the ...
Wünsch, Matthias
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Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings

Antibiotics
Antimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming’s warning about the misuse of antibiotics leading to resistant microbes.
Shyam Kumar Mishra, Tanzina Akter, Umme Laila Urmi, George Enninful, Manjulatha Sara, Jiawei Shen, Dittu Suresh, Liangjun Zheng, Elias Shiferaw Mekonen, Binod Rayamajhee, Francesco M. Labricciosa, Massimo Sartelli, Mark Willcox   +12 more
doaj   +1 more source

Cyclic Peptidomimetics as Inhibitor for miR-155 Biogenesis

, 2019
miR-155 plays key promoting roles in several cancers and emerges as an important anticancer therapeutic target. However, the discovery of small molecules that target RNAs is challenging. Peptidomimetics have been shown to be a rich source for discovering
Hao Yan (134033), Yabin Song (2513770), Mengmeng Zheng (1922920), Jianfeng Cai (295870), Fu-Sen Liang (1409368), Mi Zhou (9884), Umesh Bhattarai (3875449)   +6 more
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Use of SH2 STAT3/STAT1 peptidomimetics as anticancer drugs

, 2012
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function.
Hamilton, Andrew D., Sebti, Said M., Turkson, James, Jove, Richard   +3 more
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On-Resin Synthesis and Diversification of Macrocyclic Disulfide Bridge Peptidomimetics via Bifunctional 5-Iodo-1,4-Triazoles. [PDF]

J Org Chem
Malone MA, Shepperson OA, Simms JE, Reid AJ, Jamieson AG.   +4 more
europepmc   +1 more source

Antibacterial peptidomimetics <i>via</i> fragment display on small-molecule scaffolds. [PDF]

RSC Med Chem
Dyhr E, Cañete de Pinedo L, Frederiksen N, Bojer MS, Ingmer H, Sæbø IP, Ræder SB, Bjørås M, Helgesen E, Booth JA, Franzyk H.   +10 more
europepmc   +1 more source

Disrupting the Undruggable: Emerging Modalities for Targeting Protein-Protein Interactions in Oncology. [PDF]

Biology (Basel)
El-Tanani M, Rabbani SA, Wali AF, El-Tanani Y, Sharma S.   +4 more
europepmc   +1 more source

Structure-Guided SOCS3 Peptidomimetics: Design and Functional Characterization. [PDF]

ACS Omega
Cugudda A, La Manna S, Bucciero C, Castellano G, Malfitano AM, Marasco D.   +5 more
europepmc   +1 more source

In vitro biological activity of ferrocene peptidomimetics

, 2019
Kako bi se ispitala biološka aktivnost i različita svojstva spojeva dobivenih kemijskom sintezom ili izoliranih iz prirodnih izvora, koriste se in vitro testovi citotoksičnosti na humanim ili životinjskim staničnim linijama.
Šintić, Anamaria
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