Results 21 to 30 of about 4,910 (132)

Dipeptidyl‐peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis

Molecular Oral Microbiology, Volume 36, Issue 2, Page 145-156, April 2021., 2021
Abstract Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic microorganism that solely utilizes nutritional amino acids as its energy source and cellular constituents. The bacterium is considered to incorporate proteinaceous nutrients mainly as dipeptides, thus exopeptidases that produce dipeptides from polypeptides are ...
Takayuki K. Nemoto, Yuko Ohara Nemoto
wiley   +1 more source

How to use the MEROPS database and website to help understand peptidase specificity

Protein Science, Volume 30, Issue 1, Page 83-92, January 2021., 2021
Abstract The MEROPS website (https://www.ebi.ac.uk/merops) and database was established in 1996 to present the classification and nomenclature of proteolytic enzymes. This was expanded to include a classification of protein inhibitors of proteolytic enzymes in 2004.
Neil D. Rawlings, Alex Bateman
wiley   +1 more source

The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors [PDF]

Iranian Journal of Medical Sciences
Background: The risk of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is estimated to be far greater than that in the general population.
Samaa Salah Abd-El-Fatah, Maha A. Fathy, Mohamed Ali Alabiad, Raja Aljafil, Mai Ahmed Gobran, Enssaf A. Ahmad, Ashwag S. Alsharidah, Mohammed Alorini, Sulaiman Mohammed Alnasser, Sara A. Awadh, Enas N. Morgan   +10 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Matching maternal and paternal experiences underpin molecular thermal acclimation

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract The environment experienced by one generation has the potential to affect the subsequent one through non‐genetic inheritance of parental effects. Since both mothers and fathers can influence their offspring, questions arise regarding how the maternal, paternal and offspring experiences integrate into the resulting phenotype.
L. C. Bonzi, J. M. Donelson, R. K. Spinks, P. L. Munday, T. Ravasi, C. Schunter   +5 more
wiley   +1 more source

Pericardial Parietal Mesothelial Cells: Source of the Angiotensin-Converting-Enzyme of the Bovine Pericardial Fluid

Arquivos Brasileiros de Cardiologia
Background: Angiotensin II (Ang II), the primary effector hormone of the renin-angiotensin system (RAS), acts systemically or locally, being produced by the action of angiotensin-converting-enzyme (ACE) on angiotensin I.
Ilsione Ribeiro de Sousa Filho, Isabela Cabral Cavicchioli Pereira, Lourimar José de Morais, Livia das Graças Vieito Lombardi Teodoro, Maria Laura Pinto Rodrigues, Roseli Aparecida da Silva Gomes   +5 more
doaj   +1 more source

Quantitative Characterization of Gene Regulatory Circuits Associated With Fungal Secondary Metabolism to Discover Novel Natural Products

Advanced Science, Volume 11, Issue 47, December 18, 2024.
An advanced microfluidic platform is created to enable precise characterization of complex multicellular fungal gene regulatory circuits (GRCs) at the single‐cell level. Quantification of GRCs involved in secondary metabolite production provides new insights into gene regulation of fungal secondary metabolism and highlights the potential of synthetic ...
Xinran Xu, Yanhong Sun, Anxin Zhang, Sijia Li, Shu Zhang, Sijing Chen, Chunbo Lou, Lei Cai, Yihua Chen, Chunxiong Luo, Wen‐Bing Yin   +10 more
wiley   +1 more source

Multiomics analysis reveals the potential mechanism of high‐fat diet in dextran sulfate sodium‐induced colitis mice model

Food Science &Nutrition, Volume 12, Issue 10, Page 8309-8323, October 2024.
HFD‐treated mice exhibited notable alternations in the structure and composition of the gut microbiota, with some of these alternations being associated with the pathogenesis of IBD. Analysis of the colon transcriptome revealed 11 hub genes and 7 hub pathways among control, DSS‐induced colitis, and HFD + DSS‐treated groups. Impact of HFD on DSS‐induced
Yuyang Zhao, Zhimin Chen, Ruiyi Dong, Yufan Liu, Yixin Zhang, Yan Guo, Meiyi Yu, Xiang Li, Jiangbin Wang   +8 more
wiley   +1 more source

Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism

Macromolecular Bioscience, Volume 24, Issue 7, July 2024.
Organelle‐targeted delivery and release can maximize therapeutic effects and minimize unwanted effects. In addition, when triggering the release of payloads from nanosized drug delivery systems, spending stimulus in the target organelle can create an imbalance of intracellular regulators (e.g., redox), resulting in synergism in therapeutic outcomes ...
Hana Cho, Kang Moo Huh, Min Suk Shim, Yong‐Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang   +6 more
wiley   +1 more source

Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease

The FEBS Journal, Volume 291, Issue 14, Page 2999-3029, July 2024.
Understanding Aβ clearance by amyloid‐degrading enzymes (ADEs) is of utmost importance due to its direct association with Alzheimer's disease (AD). Aβ is a toxic peptide that aggregates in the brain, leading to amyloid plaques and neurodegeneration.
Joanna Żukowska, Stephen J. Moss, Vasanta Subramanian, K. Ravi Acharya   +3 more
wiley   +1 more source