Results 31 to 40 of about 3,788 (142)
Translational control in plants: from basic mechanisms to environmental and developmental responses
The Plant Journal, Volume 125, Issue 1, January 2026.SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons +3 more
wiley +1 more source
Effect of cytidine‐5′‐monophosphate on peptidyl transferase activity [PDF]
FEBS Letters, 1975 The transfer reaction with pA-fMet as a donor substrate is strongly stimulated by CMP, whereas the transfer reaction with CpApCpCpA-acLeu as a donor substrate is inhibited by CMP. These results indicate that the donor site of peptidyl transferase contains specific binding sites for the terminal adenosine and for the cytidylic acid residue in the ...
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Gastroenterology Research and Practice, Volume 2026, Issue 1, 2026.Background Antibiotic resistance of Helicobacter pylori (H. pylori), especially to clarithromycin, is a major cause of eradication failure worldwide. Data on the molecular mechanisms of clarithromycin resistance and their clinical impact in Central Asia remain limited. Methods This prospective study included 194 patients with H.
Jadida Ismailova +4 more
wiley +1 more source
The effect of gougerotin analogues on ribosomal peptidyl transferase
FEBS Letters, 1971 1. Introduction Gougerotin (I), a dipeptidyl pyrimidine nucleoside antibiotic, has been found to specifically inhibit the step of protein biosynthesis which is catalyzed by ribosomal peptidyl transferase [l-S] . Since three gougerotin analogues have been synthesized recently [6] , 1-[3(sarcosyl-D-seryl-)amino3-deoxy$-D-gluco- pyranosyl-)uracil (II, cf.
Černá, J. +2 more
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Puromycin–rRNA interaction sites at the peptidyl transferase center
RNA, 2000 The binding site of puromycin was probed chemically in the peptidyl-transferase center of ribosomes from Escherichia coli and of puromycin-hypersensitive ribosomes from the archaeon Haloferax gibbonsii. Several nucleotides of the 23S rRNAs showed altered chemical reactivities in the presence of puromycin.
Rodriguez-Fonseca, Christina +6 more
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Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications. [PDF]
Acc Chem Res, 2023 Polikanov YS +2 more
europepmc +1 more source
The ribosomal peptidyl transferase
, 2017 Peptide bond formation on the ribosome takes place in an active site composed of RNA. Recent progress of structural, biochemical, and computational approaches has provided a fairly detailed picture of the catalytic mechanism of the reaction. The ribosome accelerates peptide bond formation by lowering the activation entropy of the reaction due to ...
Beringer, Malte, Rodnina, Marina
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The Peptidyl Transferase Activity of Ribosomes
Cold Spring Harbor Symposia on Quantitative Biology, 1969 R E, Monro +3 more
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Peptidyl‐tRNA and peptidyl transferase activity of skeletal muscle ribosomes. Effect of diabetes [PDF]
FEBS Letters, 1970 Stirewalt, William S., Wool, Ira G.
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Photoinactivation of peptidyl transferase binding sites
FEBS Letters, 1979 Černá, J., Rychlík, I.
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