Results 1 to 10 of about 11,623 (233)

A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma [PDF]

Frontiers in Genetics, 2021
The burden of hepatocellular carcinoma (HCC) worldwide is increasing over time, while the underlying molecular mechanism of HCC development is still under exploration.
Yuwei Gu, Chao Wang, Shengsen Chen, Shengsen Chen, Jia Tang, Xiaoxiao Guo, Wei Hu, An Cui, Dian Zhang, Kangkang Yu, Mingquan Chen, Mingquan Chen   +11 more
doaj   +6 more sources

Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex generation for driving tumorigenesis [PDF]

Nature Communications
The three-stranded DNA-RNA triplex hybridization is involved in various biological processes, including gene expression regulation, DNA repair, and chromosomal stability.
Xiaoyu Zhang, Tianyi Ding, Fan Yang, Jixing Zhang, Haowen Xu, Yiran Bai, Yibing Shi, Jiaqi Yang, Chaoqun Chen, Chengbo Zhu, He Zhang   +10 more
doaj   +6 more sources

Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice. [PDF]

Eur J Immunol, 2021
Abstract Peptidyl‐prolyl cis‐trans isomerase C ( Ppic ) is expressed in several bone marrow (BM) hematopoietic progenitors and in T‐cell precursors. Since the expression profile of Ppic in the hematoimmune system ...
Paiva RS, Ramos CV, Azenha SR, Alves C, Basto AP, Graca L, Martins VC.   +6 more
europepmc   +7 more sources

Dual-Family Peptidylprolyl Isomerases (Immunophilins) of Select Monocellular Organisms [PDF]

Biomolecules, 2018
The dual-family peptidylprolyl cis-trans isomerases (immunophilins) represent a naturally occurring chimera of the classical FK506-binding protein (FKBP) and cyclophilin (CYN), connected by a flexible linker.
Sailen Barik
doaj   +7 more sources

Cyclophilin-A is bound to through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex [PDF]

Journal of Biological Chemistry, 2004
Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known.
Galigniana, Mario Daniel, Gallay, Philippe A., Morishima, Yoshihiro, Pratt, William B.   +3 more
core   +10 more sources

Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α. [PDF]

J Biol Chem, 2015
The transcriptional activity of estrogen receptor α (ERα), the key driver of breast cancer proliferation, is enhanced by multiple cellular interactions, including phosphorylation-dependent interaction with Pin1, a proline isomerase, which mediates cis-trans isomerization of the N-terminal Ser(P)(118)-Pro(119) in the intrinsically disordered AF1 ...
Rajbhandari P, Ozers MS, Solodin NM, Warren CL, Alarid ET.   +4 more
europepmc   +6 more sources

FKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulum. [PDF]

J Biol Chem, 2011
FK506-binding protein 38 (FKBP38), a membrane-anchored, tetratricopeptide repeat (TPR)-containing immunophilin, associates with nascent plasma membrane ion channels in the endoplasmic reticulum (ER). It promotes the maturation of the human ether-à-go-go-related gene (HERG) potassium channel and maintains the steady state level of the cystic fibrosis ...
Banasavadi-Siddegowda YK, Mai J, Fan Y, Bhattacharya S, Giovannucci DR, Sanchez ER, Fischer G, Wang X.   +7 more
europepmc   +6 more sources

Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F [PDF]

Cells
Hexokinase catalyzes the first rate-limiting step glycolysis. However, the roles of hexokinase 2 (HK2) in asthma remain incompletely understood. This study aimed to investigate metabolic alterations in asthma, focusing on the expression, function and ...
Zhen Tian, Hongyan Zheng, Yan Fan, Boyu Li, Zhenli Huang, Meijia Wang, Jixian Zhang, Jianping Zhao, Shanshan Wang, Jungang Xie   +9 more
doaj   +4 more sources

Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis. [PDF]

Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008
Proteins with both peptidylprolyl isomerase (PPIase) and chaperone activities play a crucial role in protein folding in the periplasm of Gram-negative bacteria. Few such proteins have been structurally characterized and to date only the crystal structure of SurA from Escherichia coli has been reported.
Wohlkönig A, Hodak H, Clantin B, Sénéchal M, Bompard C, Jacob-Dubuisson F, Villeret V.   +6 more
europepmc   +6 more sources

The Periplasmic Escherichia coli Peptidylprolyl cis,trans-Isomerase FkpA [PDF]

Journal of Biological Chemistry, 2000
We recently identified FkpA by selecting for the increased yield of antibody single-chain Fv (scFv) fragments in phage display, even of those not containing cis-prolines. We have now investigated the properties of FkpA in vitro. The peptidylprolyl cis-trans-isomerase activity of FkpA was found to be among the highest of any such enzyme with a protein ...
Kathrin Ramm, Andreas Plückthun
  +7 more sources