Cyclophilin A (CYPA; peptidylprolyl isomerase A; PPIA) [PDF]
Science-Business eXchange, 2009 openalex +2 more sources
Biochemical and Biophysical Research Communications, 1999 We report here the existence of a subfamily of eukaryotic parvulin proteins that have strong sequence homology with E. coli parvulin, but lack the WW domain found in previously described eukarytoic parvulins. We hence term members of this subfamily EPVH (eukaryotic parvulin homologue).
Stuart L. Rulten +2 more
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Resolving the functions of peptidylprolyl isomerases: insights from the mutagenesis of the nuclear FKBP25 enzyme [PDF]
Biochemical Society Transactions, 2013 Peptidylprolyl isomerases have been implicated in chromatin regulation through their association with histones, chromatin-modifying enzymes and DNA-binding transcription factors. As with other post-translational modifications to proteins, a mechanistic understanding of the regulation of biological processes is fostered by loss-of-function studies both ...
Geoff Gudavicius +4 more
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Host Cell Peptidylprolyl cis-trans Isomerases as Immune Modulators of HIV-1 Infection [PDF]
, 2020 Since the 1980s, the human immunodeficiency virus 1 (HIV-1) has been acknowledged as the trigger for AIDS, the acquired immunodeficiency syndrome. Every year, worldwide approximately 700,000 people die from late effects of HIV-1 infection and AIDS (UNAIDS, 2018).
Sarah Simone Bunten
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Interplay between acute Type A aortic dissection and pan-cancer: Clinical evidence, bioinformatics, and experimental validation [PDF]
iScienceSummary: Acute Type A Aortic Dissection (ATAAD) and cancer represent major global health burdens, yet shared mechanisms remain elusive. Epidemiological analyses linked ATAAD to increased risks of lung adenocarcinoma (LUAD) and head and neck squamous cell
Fangshun Tan +9 more
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FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability. [PDF]
J Biol Chem, 2012 Hutt DM +6 more
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A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence. [PDF]
Infect Immun, 2011 Norville IH +7 more
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Journal of Biological Chemistry, 1992 Cyclosporin A, the major immunosuppressive drug in transplantation, and the more potent therapeutic drug candidate, FK506, have led to the discovery of two superfamilies of immunosuppressant binding proteins, the cyclophilins and the FK binding proteins.
Christopher T. Walsh +2 more
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Journal of Medicinal Chemistry, 2011 Phage panning led to the discovery of a disulfide-cyclized peptide CRYPEVEIC that inhibits Pin1 activity with a K(I) of 0.5 μM. NMR chemical shift perturbation experiments show that cyclic CRYPEVEIC binds to the active site of Pin1. Pin1 residues K63 and R68, which bind the phosphate of substrate peptides, do not show a significant chemical shift ...
Kelly Duncan +9 more
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Protein peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) [PDF]
Science-Business eXchange, 2012 openalex +3 more sources