Results 31 to 40 of about 11,623 (233)
PPIL2 is a target of the JAK2/STAT5 pathway and promotes myeloproliferation via degradation of p53 [PDF]
The Journal of Clinical InvestigationThe activated JAK2/STAT pathway is characteristic of myeloproliferative neoplasms (MPNs). The pleckstrin 2 (PLEK2) signalosome is downstream of the JAK2/STAT5 pathway and plays an important role in MPN development.
Pan Wang +9 more
doaj +2 more sources
Gene, 2016 Peptidylprolyl isomerase A (PPIA) is a peptidyl-prolyl cis-trans isomerase that is known to play a critical role in the development of many human cancers. However, the precise biological function of PPIA in hepatocellular carcinoma (HCC) remains largely unclear.
Shaobing Cheng +10 more
openalex +3 more sources
Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 (PIN1); BCL2-associated X protein (BAX) [PDF]
Science-Business eXchange, 2009 openalex +2 more sources
Peptidylprolyl cis-trans isomerase NIMA-interacting 4 (PIN4; PAR14) [PDF]
Science-Business eXchange, 2013 openalex +3 more sources
Exploring Reaction Pathways for Peptidylprolyl-Isomerase [PDF]
Biophysical Journal, 2017 Pin1 enzyme is one of the peptidyl-prolyl cis/trans isomerases (PPIase), which isomerizes an omega bond of specific phospho-Serine/Threonine-Proline motifs, leading to many biological consequences. However, the isomerization mechanism has not been fully clarified yet though there are several experimental and numerical studies.
Hiroshi Fujisaki +4 more
openaire +1 more source
Distribution of Peptidyl-Prolyl Isomerase (PPIase) in the Archaea
Frontiers in Microbiology, 2021 Cis-trans isomerization of the peptide bond prior to proline is an intrinsically slow process but plays an essential role in protein folding. In vivo cis-trans isomerization reaction is catalyzed by Peptidyl-prolyl isomerase (PPIases), a category of ...
Anchal, Vineeta Kaushik, Manisha Goel
doaj +1 more source
Cyclophilin A (CyPA) Induces Chemotaxis Independent of Its Peptidylprolyl Cis-Trans Isomerase Activity [PDF]
Journal of Biological Chemistry, 2011 Fei Song +12 more
openalex +3 more sources
Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1
Frontiers in Cell and Developmental Biology, 2020 The peptidyl-prolyl cis/trans isomerase (PPIase) Pin1 is a unique enzyme that only binds to Ser/Thr-Pro peptide motifs after phosphorylation and regulates the conformational changes of the bond.
Dongmei Chen, Long Wang, Tae Ho Lee
doaj +1 more source
Visceral Adipose Tissue Inflammatory Factors (TNF-Alpha, SOCS3) in Gestational Diabetes (GDM): Epigenetics as a Clue in GDM Pathophysiology [PDF]
, 2020 Gestational diabetes (GDM) is among the most challenging diseases in westernized countries, affecting mother and child, immediately and in later life. Obesity is a major risk factor for GDM.
Henrich, Wolfgang +6 more
core +1 more source