Bioinformatics analysis and experimental validation of tumorigenic role of PPIA in gastric cancer
Scientific Reports, 2023 Gastric cancer (GC) is a malignant tumor with high incidence rate and mortality. Due to the lack of effective diagnostic indicators, most patients are diagnosed in late stage and have a poor prognosis.
Jichao Liu +3 more
doaj +1 more source
An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models [PDF]
, 2015 Tumor growth depends on the formation of new blood vessels (tumor angiogenesis) either from preexisting vessels or by the recruitment of bone marrow-derived cells.
Bill, Ruben +5 more
core +1 more source
Maintaining hepatic stem cell gene expression on biological and synthetic substrata [PDF]
, 2012 The liver is a highly resilient organ that possesses enormous regenerative capacity. This is mediated mainly through the most abundant cell type found in the liver, the hepatocyte.
Bradley, Mark +5 more
core +2 more sources
Single nucleotide polymorphisms of PIN1 promoter region and cancer risk: evidence from a meta-analysis. [PDF]
PLoS ONE, 2013 Peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) is involved in the process of tumorigenesis. The two single nucleotide polymorphisms (-677T>C, -842G>C) in the PIN1 promoter region have been suspected of being associated with cancer risk for ...
Jing-Jing Peng +7 more
doaj +1 more source
InterAKTions with FKBPs - mutational and pharmacological exploration [PDF]
, 2013 The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt,
Biondi, Ricardo M. +5 more
core +3 more sources
Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity
Frontiers in Pharmacology, 2018 Cyclophilin J (CyPJ), also called peptidylprolyl isomerase like 3, has been identified as a novel member of the cyclophilin family. Our previous research has resolved the three-dimensional structure of CyPJ and demonstrated the peptidylprolyl cis–trans ...
Xuemei Zhao +7 more
doaj +1 more source
Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. [PDF]
, 2015 Maternal diet during pregnancy influences the later life reproductive potential of female offspring. We investigate the molecular mechanisms underlying the depletion of ovarian follicular reserve in young adult females following exposure to obesogenic ...
Aiken, Catherine E +4 more
core +2 more sources
Frontiers in Cell and Developmental Biology, 2020 Pin1 is a peptidyl-prolyl cis-trans isomerase that specifically binds to a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif and catalyzes the cis-trans isomerization of proline imidic peptide bond, resulting in ...
Xiangming Hu +2 more
doaj +1 more source
Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3. [PDF]
PLoS ONE, 2015 Cyclophilins, which bind to immunosuppressant cyclosporin A (CsA), are ubiquitous proteins and constitute a multigene family in higher organisms. Several members of this family are reported to catalyze cis-trans isomerisation of the peptidyl-prolyl bond,
Gundeep Kaur +10 more
doaj +1 more source
Functional annotation of proteomic data from chicken heterophils and macrophages induced by carbon nanotube exposure [PDF]
, 2014 With the expanding applications of carbon nanotubes (CNT) in biomedicine and agriculture, questions about the toxicity and biocompatibility of CNT in humans and domestic animals are becoming matters of serious concern.
Chao-jung Chen +7 more
core +3 more sources