Results 71 to 80 of about 11,623 (233)

Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma. [PDF]

PLoS ONE, 2015
Cyclophilin J (CYPJ) is a new member of the peptidyl-prolyl cis/trans-isomerase (PPIase) identified with upregulated expression in human glioma. However, the biological function of CYPJ remained unclear.
Jian Chen, Shuai Chen, Jiahui Wang, Mingjun Zhang, Zhaohua Gong, Youheng Wei, Li Li, Yuanyuan Zhang, Xuemei Zhao, Songmin Jiang, Long Yu   +10 more
doaj   +1 more source

Proteomic characterization of the cytotoxic mechanism of gold (III) porphyrin 1a, a potential anticancer drug [PDF]

, 2006
There has been increasing interest in the potential applications of gold (III) complexes as anticancer drugs with higher cytotoxicity and fewer side effects than existing metal anticancer drugs.
Che, CM, Chiu, JF, He, QY, Wang, Y
core   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

MicroRNA-150-5p inhibits the proliferation and invasion of human larynx epidermiod cancer cells though regulating peptidyl-prolyl cis/trans isomerase

Brazilian Journal of Otorhinolaryngology, 2023
Objective: This study aimed to investigate the molecular mechanism of miR-150-5p regulating the malignant biological behavior of Human Epidermoid cancer cell (HEp-2) by targeting peptidyl-prolyl cis/trans isomerase NIMA-Interacting-1 (PIN1).
Hailin Chen, Xuwei Cai, Baowen Du, Jianpiao Cai, Zhengzheng Luo   +4 more
doaj   +1 more source

Pinning down viral proteins: a new prototype for virus–host cell interaction [PDF]

, 2010
Pin1 is an enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins.
Yoshitsugu eKojima, Akihide Ryo
core   +1 more source

Piscirickettsiosis in Farmed Turbot, Scophthalmus maximus

Journal of Fish Diseases, EarlyView.
ABSTRACT Piscirickettsia salmonis is a well‐established intracellular pathogen of farmed Atlantic salmon around the world. The bacterium has also been detected from a number of other hosts including lumpfish (Cyclopterus lumpus), seabass (Dicentrarchus labrax) and rainbow trout (Oncorhynchus mykiss).
Hanne K. Nilsen, Magne Kjerulf Hansen, Raoul Kuiper, Jan Inge Øvrebø, Kjersti Sturød, Maryam Saghafian, Snorre Gulla, Anne Berit Olsen, Duncan J. Colquhoun, Ole Bendik Dale   +9 more
wiley   +1 more source

Development of a contacting transwell co-culture system for the in vitro propagation of primary central nervous system lymphoma

Frontiers in Cell and Developmental Biology, 2023
Primary central nervous system lymphoma (PCNSL) is a malignant neoplasm of the central nervous system that is refractory to treatment and has extremely poor prognosis. One factor hindering the development of therapeutic options for PCNSL is its molecular
Mayuko Nishi, Mayuko Nishi, Kensuke Tateishi, Kensuke Tateishi, Jeremiah Stanleyraj Sundararaj, Yoko Ino, Yusuke Nakai, Yusuke Nakai, Yasuyoshi Hatayama, Yasuyoshi Hatayama, Yutaro Yamaoka, Yutaro Yamaoka, Yusaku Mihana, Yusaku Mihana, Kei Miyakawa, Kei Miyakawa, Hirokazu Kimura, Yayoi Kimura, Tetsuya Yamamoto, Akihide Ryo, Akihide Ryo   +20 more
doaj   +1 more source

MicroRNA-296-5p is differentially expressed in individuals with and without HIV-1 infection [PDF]

Genetics and Molecular Biology, 2020
MicroRNAs are considered as potential biomarkers, agents, or therapeutic targets; few studies have addressed the expression of miRNAs in treatment-naïve patients infected with HIV-1.
Jhonathan Cárdenas-Bedoya, Jazmin Marquez-Pedroza, María Cristina Morán-Moguel, Martha Escoto-Delgadillo, Eduardo Vázquez-Valls, Gracia Viviana González-Enríquez, Alma Minerva Pérez-Ríos, Blanca Miriam Torres-Mendoza   +7 more
doaj   +1 more source

Visceral adipose tissue alteration of PI3KR1 expression is associated with gestational diabetes but not promoter DNA methylation [PDF]

, 2019
Obesity and diabetes are at an epidemic rate, as well as growing incidences of gestational diabetes mellitus (GDM) which causes pregnancy risks, and harm in both maternal and child health.
Henrich, Wolfgang, Melchior, Kerstin, Ott, Raffael, Plagemann, Andreas, Rancourt, Rebecca C., Schellong, Karen, Zirka, Thomas   +6 more
core   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, Volume 111, Issue 4, Page 2026-2043, 1 April 2026.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source