Results 181 to 190 of about 5,492 (203)

Synthesis of nucleobase-functionalized β-peptoids and β-peptoid hybrids

Tetrahedron Letters, 2006
Abstract The solid-phase synthesis of a new class of nucleobase-modified peptide-mimetic oligomers is described. β-Peptoids and β-peptoid hybrids bearing thymine on the side chain are prepared from N-Fmoc-N-[2-(thymin-1-yl)ethyl]-β-alanine.
Xavier Mejías, Lidia Feliu, Marta Planas, Eduard Bardají   +3 more
openaire   +1 more source

Peptoids as endothelin receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2001
A series of new peptoids as endothelin receptor antagonists has been synthesized. Screening them for their ability to bind with endothelin receptors (ET(A) and ET(B)) competitively in the presence of (125I) endothelin led to the discovery of compounds as possible leads with IC50s in the low micromolar concentrations.
F, Dasgupta, N, Gangadhar, M, Bruhaspathy, A K, Verma, S, Sarin, A K, Mukherjee   +5 more
openaire   +2 more sources

Antifouling Peptoid Biointerfaces

2020
Recent advances in synthetic chemistry has led to the increasingly sophisticated design and preparation of biofunctional polymeric surfaces and materials. In this regard, synthetic poly-(N-substituted glycine) “peptoids” which mimic the structure and function of peptides play an important role, since they may attain functionalities similar to natural ...
Varun Saxena, Martyn G. L. Merrilees, King Hang Aaron Lau   +2 more
openaire   +1 more source

Peptoids and Peptide–Peptoid Hybrid Biopolymers as Peptidomimetics

2013
Peptoids (oligomers of N-substituted glycine residues) and peptide-peptoid hybrid polymers (peptomers) are interesting classes of compounds mimicking structure and function of biologically active peptides. The oligomeric peptidomimetics such as peptoids are particularly important compounds since they provide access to an enormous molecular diversity ...
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Antifouling Poly(β-peptoid)s

Biomacromolecules, 2011
A new type of polymer highly resistant to nonspecific protein adsorption is reported. Poly(N-methyl-β-alanine) (PMeA) and poly(N-ethyl-β-alanine) (PEtA) synthesized via cobalt-catalyzed carbonylative polymerization of N-methylaziridine and N-ethylaziridine were end-functionalized with thiol groups and grafted onto Au surfaces.
Shaohui, Lin, Bo, Zhang, Michael J, Skoumal, Brian, Ramunno, Xiaopeng, Li, Chrys, Wesdemiotis, Lingyun, Liu, Li, Jia   +7 more
openaire   +2 more sources

A fluorescent peptoid pH‐sensor

Peptide Science, 2013
ABSTRACTPeptoids, N‐substituted glycine oligomers, can adopt stable three‐dimensional structures and have found diverse application as peptide surrogates and as nanomaterials. In this report, we have expanded peptoid function to include pH sensing by coupling pH‐induced peptoid conformational changes with fluorescence intensity changes.
Amelia A, Fuller, Courtney A, Holmes, Frederick J, Seidl   +2 more
openaire   +2 more sources

Development of Spiroligomer–Peptoid Hybrids

The Journal of Organic Chemistry, 2017
Creating functional macromolecules that possess the diversity and functionality of proteins poses an enormous challenge, as this requires large, preorganized macromolecules to facilitate interactions. Peptoids have been shown to interact with proteins, and combinatorial libraries of peptoids have been useful in discovering new ligands for protein ...
Justin D. Northrup, Giulia Mancini, Claire R. Purcell, Christian E. Schafmeister   +3 more
openaire   +2 more sources

Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide–peptoid hybrids

Bioorganic & Medicinal Chemistry, 2009
The search for novel, generally applicable and highly efficient delivery tools is a major activity in the biotechnology arena. Using highly optimized microwave based solid-phase chemistry a series of fluorescein-labelled cationic peptoid conjugates were synthesized within 24h and cellular uptake into HeLa, L929 and K562 cells examined via flow ...
Asier, Unciti-Broceta, Franziska, Diezmann, Chiung Ying, Ou-Yang, Mario Antonio, Fara, Mark, Bradley   +4 more
openaire   +2 more sources

Peptoid–Peptide Hybrid Backbone Architectures

ChemBioChem, 2010
AbstractPeptidomimetic oligomers and foldamers have received considerable attention for over a decade, with β‐peptides and the so‐called peptoids (N‐alkylglycine oligomers) representing prominent examples of such architectures. Lately, hybrid or mixed backbones consisting of both α‐ and β‐amino acids (α/β‐peptides) have been investigated in some detail
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ChemInform Abstract: ′Peptoid′ Design

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. C. HORWELL, W. HOWSON, D. C. REES
openaire   +1 more source