Results 71 to 80 of about 49,701 (247)

Engineered CAR-T-Derived Exosomes Co-Delivering miR-145 and Cytotoxic Proteins for Targeted Solid Tumour Therapy. [PDF]

J Extracell Vesicles
ABSTRACT Chimeric antigen receptor T cell (CAR‐T) therapy has demonstrated remarkable efficacy in haematologic malignancies but remains constrained in solid tumours due to limited tumour penetration, immunosuppressive microenvironments and the risk of cytokine release syndrome (CRS).
Yang R, Wang H, Wang G, Yuan G, Wei Z, An J, Hu D, Wen W, Gao S, Wan Y, Liang G.   +10 more
europepmc   +2 more sources

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

An inframe perforin gene deletion in familial hemophagocytic lymphohistiocytosis is associated with perforin expression [PDF]

American Journal of Hematology, 2004
Familial hemophagocytic lymphohistiocytosis is an autosomal recessive disease of early childhood manifested by hypercytokinemia and organ infiltration of macrophages and activated lymphocytes, and it is characterized by a fulminant clinical course. The molecular mechanism underlying this disease appears to be a deregulation of apoptosis of activated T ...
Shanmugakonar, Muralitharan, Zakia, Al Lamki, David, Dennison, Brian Sidney, Christie, Yasser A, Wali, Mathew, Zachariah, Marc, Romana, Riad, Bayoumi, Rajagopal, Krishnamoorthy   +8 more
openaire   +2 more sources

Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption

Journal of Neuroinflammation, 2016
BackgroundCD8 T cell-mediated blood-brain barrier (BBB) disruption is dependent on the effector molecule perforin. Human perforin has extensive single nucleotide variants (SNVs), the significance of which is not fully understood. These SNVs can result in
Robin C Willenbring, F. Jin, D. Hinton, M. Hansen, D. Choi, K. Pavelko, Aaron J. Johnson   +6 more
semanticscholar   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition

Oncoimmunology, 2016
Perforin, a pore-forming toxin released from secretory granules of NK cells and CTLs, is essential for their cytotoxic activity against infected or cancerous target cells.
M. Chaudhry, K. Gilmour, Imran G. House, M. Layton, N. Panoskaltsis, M. Sohal, J. Trapani, I. Voskoboinik   +7 more
semanticscholar   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Immunological profile and its clinical implications in pediatric infectious mononucleosis

Frontiers in Pediatrics
ObjectiveTo analyze the differences in peripheral blood immune function between children with infectious mononucleosis (IM) who developed liver injury (LI) and those non-liver injury (NLI), and to investigate the regulatory role of immune markers in IM ...
Jie Wang, Xinfeng Zhao, Cuiying Ye, Xudong Xu   +3 more
doaj   +1 more source

Caspase-7 activates ASM to repair gasdermin and perforin pores

Nature, 2022
K. Nozaki, Vivien I Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, W. Nash, H. N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, J. Whitmire, Edward A. Miao   +14 more
semanticscholar   +1 more source

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.

Immunity, 2007
Granzyme B is important for the ability of NK cells and CD8(+) T cells to kill their targets. However, we showed here that granzyme B-deficient mice clear both allogeneic and syngeneic tumor cell lines more efficiently than do wild-type (WT) mice.
Xuefang Cao, Sheng F. Cai, T. Fehniger, Jiling Song, Lynne I Collins, D. Piwnica-Worms, T. Ley   +6 more
semanticscholar   +1 more source