Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]
Molecular Neurodegeneration, 2018 Background Clearance at the blood-brain barrier (BBB) plays an important role in removal of Alzheimer’s amyloid-β (Aβ) toxin from brain both in humans and animal models. Apolipoprotein E (apoE), the major genetic risk factor for AD, disrupts Aβ clearance
Qingyi Ma +9 more
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Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain [PDF]
Acta Neuropathologica CommunicationsMicrovascular circulation in the brain is often impaired in connection with the loss of pericytes in old age. The neurotrophic factor BDNF also decreases in the aging brain.
Qinghua Luo +9 more
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Pericytes as mediators of infiltration of macrophages in multiple sclerosis
Journal of Neuroinflammation, 2021 Background Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system (CNS). It is associated with blood–brain barrier (BBB) breakdown and intravasation of leukocytes, particularly monocyte-derived macrophages, into the CNS ...
Deepak Kumar Kaushik +3 more
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Pericytes and Neurovascular Function in the Healthy and Diseased Brain
Frontiers in Cellular Neuroscience, 2019 Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century.
Lachlan S. Brown +5 more
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Emerging Role of Pericytes and Their Secretome in the Heart
Cells, 2021 Pericytes, as mural cells covering microvascular capillaries, play an essential role in vascular remodeling and maintaining vascular functions and blood flow.
Han Su +4 more
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eLife, 2018 Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, most notably α-smooth muscle actin
Luis Alarcon-Martinez +7 more
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Immunoregulatory Roles of Tumor‐Originated Pericytes Identified by Single‐Cell Analysis in Glioblastoma [PDF]
Advanced SciencePericytes as critical vascular support cells not only keep the integrity of blood–brain barrier but also play profound roles in brain tumors. Yet the origin and functional heterogeneity of pericytes in the most common malignant brain tumor glioblastoma ...
Cuiying Chu +16 more
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Transplantation of hiPSC-derived pericytes rescues Alzheimer’s disease phenotypes in APOE4/4 mice through IGF2-rich apoptotic vesicles [PDF]
Translational NeurodegenerationBackground Effective therapies for Alzheimer’s disease (AD) remain to be developed. APOE4 is the strongest genetic risk factor for late-onset AD. Pericyte degeneration and blood–brain barrier (BBB) disruption are thought to be early biomarkers of AD and ...
Chuanfeng Xiong +19 more
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Screening and identification of muscle pericyte selective markers [PDF]
Scientific ReportsPericytes, which share markers with smooth muscle cells (SMCs), are heterogenous cells. Pericytes in the brain and skeletal muscle have different embryonic origins, representing distinct subpopulations.
Jingsong Ruan +5 more
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Pericytes for Therapeutic Approaches to Ischemic Stroke
Frontiers in Neuroscience, 2021 Pericytes are perivascular multipotent cells located on capillaries. Although pericytes are discovered in the nineteenth century, recent studies have found that pericytes play an important role in maintaining the blood—brain barrier (BBB) and regulating ...
Lu Cao +4 more
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