Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain [PDF]
Acta Neuropathologica CommunicationsMicrovascular circulation in the brain is often impaired in connection with the loss of pericytes in old age. The neurotrophic factor BDNF also decreases in the aging brain.
Qinghua Luo +9 more
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Pericytes for Therapeutic Approaches to Ischemic Stroke
Frontiers in Neuroscience, 2021 Pericytes are perivascular multipotent cells located on capillaries. Although pericytes are discovered in the nineteenth century, recent studies have found that pericytes play an important role in maintaining the blood—brain barrier (BBB) and regulating ...
Lu Cao +4 more
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The Neuroinflammatory Role of Pericytes in Epilepsy
Biomedicines, 2021 Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a crucial role in BBB integrity and are also implicated in neuroinflammation. The association between pericytes, BBB dysfunction, and the pathophysiology of
Gaku Yamanaka +6 more
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Descending Vasa Recta Endothelial Membrane Potential Response Requires Pericyte Communication. [PDF]
PLoS ONE, 2016 Using dual-cell electrophysiological recording, we examined the routes for equilibration of membrane potential between the pericytes and endothelia that comprise the descending vasa recta (DVR) wall.
Zhong Zhang +2 more
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Pericytes as mediators of infiltration of macrophages in multiple sclerosis
Journal of Neuroinflammation, 2021 Background Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system (CNS). It is associated with blood–brain barrier (BBB) breakdown and intravasation of leukocytes, particularly monocyte-derived macrophages, into the CNS ...
Deepak Kumar Kaushik +3 more
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The Role of Pericytes in Regulation of Innate and Adaptive Immunity
Biomedicines, 2023 Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they support vasculature functioning, participate in tissue regeneration, and regulate blood flow.
Siarhei A. Dabravolski +6 more
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Tissue Specific Origin, Development, and Pathological Perspectives of Pericytes
Frontiers in Cardiovascular Medicine, 2018 Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes play critical roles in maturation and maintenance of vascular branching morphogenesis.
Tomoko Yamazaki +2 more
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Matricellular Protein Periostin Promotes Pericyte Migration in Fibrotic Airways
Frontiers in Allergy, 2021 Introduction: Periostin is a matricellular protein that is currently used as a biomarker for asthma. However, its contribution to tissue remodeling in allergic asthma is currently unknown.
Rebecca E. Bignold, Jill R. Johnson
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Endogenous brain pericytes are widely activated and contribute to mouse glioma microvasculature. [PDF]
PLoS ONE, 2015 Glioblastoma multiforme (GBM) is the most common brain tumor in adults. It presents an extremely challenging clinical problem, and treatment very frequently fails due to the infiltrative growth, facilitated by extensive angiogenesis and ...
Andreas Svensson +4 more
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Brain Microvascular Pericytes—More than Bystanders in Breast Cancer Brain Metastasis
Cells, 2022 Brain tissue contains the highest number of perivascular pericytes compared to other organs. Pericytes are known to regulate brain perfusion and to play an important role within the neurovascular unit (NVU).
Danyyl Ippolitov +3 more
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