Results 121 to 130 of about 10,316 (244)

Pericytes modulate endothelial inflammatory response during bacterial infection

mBio
Pericytes are located around blood vessels, in close contact with endothelial cells. We discovered that pericytes dampen pro-inflammatory endothelial cell responses. Endothelial cells co-cultured with pericytes had markedly reduced expression of adhesion
Thaynara P. Carvalho, Frank A. O. Toledo, Diego F. A. Bautista, Monique F. Silva, Jefferson B. S. Oliveira, Pâmela A. Lima, Fabíola B. Costa, Noelly Q. Ribeiro, Jee-Yon Lee, Alexander Birbrair, Tatiane A. Paixão, Reneé M. Tsolis, Renato L. Santos   +12 more
doaj   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Pericytes in the disease spotlight

Trends in Cell Biology
Pericytes are known as the mural cells in small-caliber vessels that interact closely with the endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when dysfunctional contribute to vasculature-related diseases such as diabetic retinopathy and neurodegenerative conditions.
van Splunder, Hielke, Villacampa, Pilar, Martínez-Romero, Anabel, Graupera, Mariona   +3 more
openaire   +3 more sources

Pericytes: brain-immune interface modulators

, 2014
The premise that the central nervous system is immune-privileged arose from the fact that direct contact between immune and nervous cells is hindered by the blood-brain barrier.
Adrian M. Cabañas-Morales, Gabriela eHurtado-Alvarado, Beatriz eGomez-Gonzalez, Gabriela Hurtado-Alvarado, Beatriz Gómez-Gónzalez, Adrian Michel eCabañas-Morales   +5 more
core   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

Transplantation of hiPSC-derived pericytes rescues Alzheimer’s disease phenotypes in APOE4/4 mice through IGF2-rich apoptotic vesicles

Translational Neurodegeneration
Background Effective therapies for Alzheimer’s disease (AD) remain to be developed. APOE4 is the strongest genetic risk factor for late-onset AD. Pericyte degeneration and blood–brain barrier (BBB) disruption are thought to be early biomarkers of AD and ...
Chuanfeng Xiong, Yao Tang, Junhua Chen, Mingming Fan, Lan Wei, Zhaoran Dong, Xingqiang Lai, Xuejiao Men, Qiumin Chen, Dairui Li, Wenjin Ye, Yuanchen Ma, Xiaoyong Chen, Weijun Huang, Zhengqi Lu, Hong Chen, Yunfeng Shen, Yanming Chen, Andy Peng Xiang, Weiqiang Li   +19 more
doaj   +1 more source

Isolation and Culture of Primary Pericytes from Mouse

Bio-Protocol
Pericytes are essential for tissue homeostasis, functioning to regulate capillary blood flow. Dysfunctional pericytes are implicated in various pathologies, including cancer progression.
Tamara McErlain, Cristina Branco, Meera Murgai   +2 more
doaj   +1 more source

Effect of pericytes on melanoma development.

, 2012
83 Background: Melanoma-associated stroma cells regulate tumor establishment, invasion, and dissemination through paracrine and heterotypic cell-cell interactions with cancer cells. Pericytes constitute a major noninflammatory component of the melanoma-
Jose Humberto Trevino-Villarreal, Rick A. Rogers, Rosalinda Sepulveda, Douglas A. Cotanche   +3 more
core   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Glaucoma, Capillaries and Pericytes. 4. Beta-Adrenergic Activation of Cultured Retinal Pericytes

, 1996
To characterize the relaxation of pericytes induced by β-adrenergic stimulation, changes in the contractile tone of pericytes were quantified as a change in the wrinkling of an elastic silicone surface on which they were cultured.
Davis, Barry, Zschauer, Aino O.A, Anderson, Douglas R   +2 more
core   +1 more source