Results 171 to 180 of about 87,628 (306)

FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury. [PDF]

Nat Commun
Sun F, Zhao Y, Do J, Cheng P, Li E, Liu Y, Shirazi SP, Sucre JMS, Kalin TV, He H, Kalinichenko VV.   +10 more
europepmc   +1 more source

Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells

Brain Pathology, EarlyView.
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son, Suji Kim, Min‐Tae Jeon, Moonseok Choi, Kyu‐Sung Kim, Suji Lee, Seung‐Yeol Nah, Do‐Geun Kim   +7 more
wiley   +1 more source

Pericytes and mesenchymal stromal cells converge toward pro-tumor phenotypes in the tumor microenvironment. [PDF]

Discov Oncol
La Spina E, Giallongo C, Longhitano L, Ferrigno J, Di Rosa G, Del Fabro V, Calvo D, Giallongo S, Romano D, Duminuco A, Palumbo GA, Galvano F, Li Volti G, Barbagallo IA, Tibullo D.   +14 more
europepmc   +1 more source

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, EarlyView.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato, Satoru Miyawaki, Yu Sakai, Kenta Ohara, Yu Teranishi, Yudai Hirano, Motoyuki Umekawa, Takahiro Tsuchiya, Shotaro Ogawa, So Hirata, Hiroki Hongo, Hideaki Ono, Daisuke Komura, Tetsuo Ushiku, Shumpei Ishikawa, Nobuhito Saito   +15 more
wiley   +1 more source

GLP-1 activates K_ATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection. [PDF]

Nat Commun
Mastitskaya S, de Freitas FSS, Evans LE, Attwell D.   +3 more
europepmc   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Occludin modulates HIV and ischaemic stroke response via the mitochondrial antiviral signalling pathway. [PDF]

Brain
Torices S, Moreno T, Osborne OM, Ramaswamy S, Naranjo O, Teglas T, Park M, Sun E, Toborek M.   +8 more
europepmc   +1 more source

Opinion: Inhibition of Blood-Brain Barrier Repair as a Mechanism in HIV-1 Disease. [PDF]

, 2017
Maubert, Monique E., Nonnemacher, Michael R., Wigdahl, Brian   +2 more
core   +2 more sources

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Junctions, Transporters, and Interactions of Endothelial Cells: Regulation by Ethanol. [PDF]

Int J Mol Sci
Mandyam CD, Vandekerkhoff A, Jung S, Kharidia D, Ponomarev I, Kisby B.   +5 more
europepmc   +1 more source