Results 171 to 180 of about 67,690 (294)

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

Pericytes as key mediators of microenvironmental signaling crosstalk: implications in vascular diseases and cancer. [PDF]

Front Cell Dev Biol
Guo Q, Yao Y, Ding Y, Chen L, Zhang Q, Zhang H, Xue J.   +6 more
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Glutathione-Related Responses to Hyperglycemic and Hyperosmotic Stress in Cultured Human Retinal Pericytes and Endothelial Cells: An Exploratory Study. [PDF]

Biomedicines
Pavlovschi E, Darii F, Pantea V, Curtev Ș, Trocin C, Curlat S, Ușurelu DC, Mărițoi T, Tagadiuc O.   +8 more
europepmc   +1 more source

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

FAP⁺ pericyte-like cells promote monocyte differentiation into tumor-associated macrophages in glioblastoma. [PDF]

Exp Mol Med
Houdova Megova M, Shard C, Vymolova B, Ternerova N, Svablova T, Buna T, Straka D, Vanickova Z, Krepela E, Kupcova Skalnikova H, Kolar M, Sachova J, Kubovciak J, Balaziova E, Vymola P, Hrabal P, Ebert LM, Patil A, Tomas R, Netuka D, Gomez GA, Busek P, Sedo A.   +22 more
europepmc   +1 more source

SpaceNet: Pathology‐guided analysis of lesion‐associated spatial molecular programs

iMetaOmics, EarlyView.
Disease‐associated molecular alterations are often confined to localized pathological regions, yet current spatial transcriptomic analyses do not always use pathology or imaging information as the primary reference for defining disease‐relevant spatial contexts.
Menglei Wang, Qikun Zhao, Hudong Bao, Kaiyu Jin, Xiaohui Fan, Jie Liao   +5 more
wiley   +1 more source

Rapid derivation of cloning-competent cells from peripheral blood advances conservation biobanking. [PDF]

J Hered
Knecht L, Mastracci Iv A, Harbert R, Charles F, Kuperman-Yao LL, Miyawaki T, Gedman GL, Pirovich KM, Herrick J, Lay L, Ledesma A, Metzler S, Milutinovitch D, Papizan JB, Pennington P, Russell L, Ryan K, Srirattana K, Steiger K, Tourzani DA, Walker K, Sampaio RV, Bocklandt S, Lamm B, James M, Walker S, Shapiro B, Kehler J.   +27 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Lineage-Driven Understanding of Human Pericyte Heterogeneity in Vascular Modeling and Regeneration. [PDF]

Int J Stem Cells
Lee S, Baek CM, Lee S, Jo MG, Kim YJ.
europepmc   +1 more source