Results 191 to 200 of about 67,690 (294)

Therapeutic Potential of Platelet-Derived Growth Factor B-Modified Nanoparticles in Enhancing Pericyte Activation for Acute Ischemic Stroke. [PDF]

eNeuro
Karashima S, Arimura K, Hatae R, Takagishi S, Narahara S, Kawano T, Tanaka S, Kurogi R, Nakamizo A, Murata M, Yoshimoto K.   +10 more
europepmc   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Clazosentan Attenuates Endothelin-1-Induced ETA Protein Upregulation and Contractile Sensitization in Brain Pericytes. [PDF]

Pharmaceutics
Chikamatsu G, Nakagawa S, Morofuji Y, Shiozaki E, Ogawa Y, Okamura K, Matsunaga Y, Watanabe D, Walter FR, Izumo T, Niwa M, Deli MA, Matsuo T.   +12 more
europepmc   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA/PI3K/AKT Pathway

Pediatric Discovery, EarlyView.
MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen, Chenxi Jia, Zhuocheng Shi, Bianan Zhu, Yihang Yu, Xing Liu, Feng Liu, Jianwei Chen, Tao Xu, Yuanyuan Zhang, Deying Zhang, Guanghui Wei   +11 more
wiley   +1 more source

Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer's Disease. [PDF]

Int J Mol Sci
Arbănași EM, Arbănași EM, Boghițoiu TG, Cărare SA, Cordoș BA, Braysh K, Suciu N, Chinezu L, Manu DR, Montagne A, Dewing J, Russu E, Bănescu CV, Voidăzan ST, Cărare RO.   +14 more
europepmc   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Emergence of fibrotic pericytes and their transcriptional regulation in pulmonary fibrosis. [PDF]

Nat Commun
Gao W, Lan YW, Deng Z, Li E, Acharya A, Do J, Xia X, Marquez N, Lu D, Siraj AA, Banovich NE, Sureshbabu A, Bremner R, Kalinichenko VV, Kalin TV.   +14 more
europepmc   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

KLF2 Is Associated with ERK1/2-MAP2 Activation and Neuron-like Phenotypic Remodeling of PDGFR-β-Lineage Cells Following Ischemic Stroke. [PDF]

Brain Sci
Liu Q, Xu S, Zhang B, Lv C, Liu C, Wang Y, Zhou H, Luo Y, Li S.   +8 more
europepmc   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source