Results 181 to 190 of about 106,411 (380)

798 A role for dermal pericytes on ex vivo human skin barrier function [PDF]

, 2023
Y. Toba-Ichihashi, M. Yokota, T. Yoshino, T. Sakurai, M. Tominaga, K. Takamori   +5 more
openalex   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

Developmental Cell, 2011
A. Armulik, G. Genové, C. Betsholtz
semanticscholar   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

Nature Medicine, 2020
Joel W. Blanchard, Michael Bula, J. Dávila-Velderrain, L. Akay, Lena Zhu, Alexander Frank, Matheus B. Victor, J. M. Bonner, Hansruedi Mathys, Yuan-Ta Lin, Tak Ko, D. Bennett, Hugh P Cam, Manolis Kellis, L. Tsai   +14 more
semanticscholar   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis [PDF]

, 2012
Ching-Fang Wu, Wen‐Chih Chiang, Chun‐Fu Lai, Fan‐Chi Chang, Yi‐Ting Chen, Yu‐Hsiang Chou, Ting-Hui Wu, Geoffrey Linn, Hong Ling, Kwan‐Dun Wu, Tun‐Jun Tsai, Yung‐Ming Chen, Jeremy S. Duffield, Shuei‐Liong Lin   +13 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy

, 2014
Brian J. Siroky, Hong Yin, Bradley P. Dixon, Ryan Reichert, Anna R. Hellmann, Thiruvamoor Ramkumar, Zenta Tsuchihashi, Marlene A. Bunni, Joshua C Dillon, P. Darwin Bell, Julian R. Sampson, John J. Bissler   +11 more
openalex   +1 more source

Pericyte–fibroblast transition promotes tumor growth and metastasis [PDF]

, 2016
Kayoko Hosaka, Yunlong Yang, Takahiro Seki, Carina Fischer, Olivier Dubey, Erik Fredlund, Johan Hartman, Piotr Religa, Hiromasa Morikawa, Yoko Ishii, Masakiyo Sasahara, Ola Larsson, Giulio Cossu, Renhai Cao, Sharon Lim, Yihai Cao   +15 more
openalex   +1 more source