Results 11 to 20 of about 106,411 (380)

Pericytes and the Control of Blood Flow in Brain and Heart

Annual Review of Physiology, 2023
Pericytes, attached to the surface of capillaries, play an important role in regulating local blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with confocal and multiphoton imaging techniques, the 3D structure ...
T. Longden, Gui-ling Zhao, A. Hariharan, W. Lederer   +3 more
semanticscholar   +1 more source

The Neuroinflammatory Role of Pericytes in Epilepsy

Biomedicines, 2021
Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a crucial role in BBB integrity and are also implicated in neuroinflammation. The association between pericytes, BBB dysfunction, and the pathophysiology of
Gaku Yamanaka, Fuyuko Takata, Yasufumi Kataoka, Kanako Kanou, Shinichiro Morichi, Shinya Dohgu, Hisashi Kawashima   +6 more
doaj   +1 more source

Microglia directly associate with pericytes in the central nervous system

Glia, 2023
Cerebral blood flow (CBF) is important for the maintenance of brain function and its dysregulation has been implicated in Alzheimer's disease (AD). Microglia associations with capillaries suggest they may play a role in the regulation of CBF or the blood–
Gary P. Morris, Catherine G. Foster, J. Courtney, J. Collins, J. M. Cashion, Lachlan S. Brown, David W. Howells, G. DeLuca, A. Canty, A. King, J. Ziebell, B. Sutherland   +11 more
semanticscholar   +1 more source

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]

, 2013
We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Chillo, Omary, Deindl, Elisabeth, Hinkel, Rabea, Kupatt, Christian, Lee, Seungmin, Qin, Di, Trenkwalder, Teresa   +6 more
core   +13 more sources

Cardiac Pericytes Acquire a Fibrogenic Phenotype and Contribute to Vascular Maturation After Myocardial Infarction

Circulation, 2023
BACKGROUND: Pericytes have been implicated in tissue repair, remodeling, and fibrosis. Although the mammalian heart contains abundant pericytes, their fate and involvement in myocardial disease remains unknown.
Linda Alex, I. Tuleta, Silvia C Hernandez, Anis Hanna, Harikrishnan Venugopal, Maider Astorkia, Claudio Humeres, A. Kubota, Kai Su, D. Zheng, N. Frangogiannis   +10 more
semanticscholar   +1 more source

Pericytes regulate vascular immune homeostasis in the CNS

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The CNS vasculature tightly regulates the passage of circulating molecules and leukocytes into the CNS. In the neuroinflammatory disease multiple sclerosis (MS), these regulatory mechanisms fail, and autoreactive T cells invade the CNS via ...
Orsolya Török, B. Schreiner, Johanna Schaffenrath, Hsing-Chuan Tsai, Upasana Maheshwari, S. Stifter, Christina A. Welsh, Ana Amorim, Sucheta Sridhar, Sebastian G. Utz, Wiebke Mildenberger, S. Nassiri, M. Delorenzi, A. Aguzzi, M. Han, M. Greter, B. Becher, A. Keller   +17 more
semanticscholar   +1 more source

Descending Vasa Recta Endothelial Membrane Potential Response Requires Pericyte Communication. [PDF]

PLoS ONE, 2016
Using dual-cell electrophysiological recording, we examined the routes for equilibration of membrane potential between the pericytes and endothelia that comprise the descending vasa recta (DVR) wall.
Zhong Zhang, Kristie Payne, Thomas L Pallone   +2 more
doaj   +1 more source

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease

Communications Biology, 2022
Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alzheimer’
Leon C. D. Smyth, Blake Highet, D. Jansson, Jane Wu, Justin Rustenhoven, M. Aalderink, Adelie Y. S. Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, R. Handley, P. Narayan, Malvindar K. Singh-Bains, P. Schweder, C. Turner, E. Mee, P. Heppner, J. Correia, T. Park, M. Curtis, R. Faull, M. Dragunow   +21 more
semanticscholar   +1 more source

Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling

Cell Research, 2021
Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression and frequent recurrence. Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche, but their function in mediating ...
Xiao-Ning Zhang, Kaidi Yang, Cong Chen, Zhi-cheng He, Qiang Wang, Hua Feng, S. Lv, Yan Wang, M. Mao, Qing Liu, Yaoyao Tan, Wen-ying Wang, Tianhong Li, Lin Che, Zhong-Yi Qin, Ling Wu, Minhua Luo, C.-H. Luo, Yuqi Liu, Wen Yin, Chao Wang, Haimei Guo, Qing-Rui Li, Bin Wang, Wei Chen, Shuang Wang, Yu Shi, X. Bian, Y. Ping   +28 more
semanticscholar   +1 more source

The Role of Pericytes in Regulation of Innate and Adaptive Immunity

Biomedicines, 2023
Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they support vasculature functioning, participate in tissue regeneration, and regulate blood flow.
Siarhei A. Dabravolski, Elena R. Andreeva, Ilya I. Eremin, Alexander M. Markin, Irina I. Nadelyaeva, Alexander N. Orekhov, Alexandra A. Melnichenko   +6 more
doaj   +1 more source