Results 11 to 20 of about 86,775 (289)

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]

Molecular Neurodegeneration, 2018
Background Clearance at the blood-brain barrier (BBB) plays an important role in removal of Alzheimer’s amyloid-β (Aβ) toxin from brain both in humans and animal models. Apolipoprotein E (apoE), the major genetic risk factor for AD, disrupts Aβ clearance
Qingyi Ma, Zhen Zhao, Abhay P Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B Verghese, Joachim Herz, David M Holtzman, Berislav V Zlokovic   +9 more
doaj   +4 more sources

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]

, 2013
We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Chillo, Omary, Deindl, Elisabeth, Hinkel, Rabea, Kupatt, Christian, Lee, Seungmin, Qin, Di, Trenkwalder, Teresa   +6 more
core   +13 more sources

Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]

, 2020
Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara, Nwadozi, Emmanuel, Rudnicki, Martina   +2 more
core   +1 more source

The Cochlear Pericytes [PDF]

Microcirculation, 2008
ABSTRACTObjectives: Cochlear pericytes are not well characterized. The aim of this study was to further advance the characterization of cochlear pericyte location and distribution, with particular focus on pericyte‐related proteins on the capillaries of the cochlear lateral wall that are functionally integral to structure, contraction, and gap junction
Xiaorui, Shi, Weijiu, Han, Hiroshi, Yamamoto, Wenxue, Tang, Xi, Lin, Ruijuan, Xiu, Dennis R, Trune, Alfred L, Nuttall   +7 more
openaire   +2 more sources

Renal pericytes: regulators of medullary blood flow [PDF]

, 2012
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Agmon Y., Beach R.E., Biondi M., Burnstock G., Casellas D., Cohen H.J., Edwards R.M., Guan Z., Harrison‐Bernard L.M., Harrison‐Bernard L.M., Jamison R.L., Kreisberg M.S., Kriz W., Larson T.S., Lazarowski E.R., Lerman L.O., Majid D.S., Pallone T.L., Rouget C., Seldin D.W., Stern M.D., Strick D.M., Takenaka T., Takezawa K., Turner M.R., Unwin R.J., Yamagishi S., Yang S.   +27 more
core   +1 more source

Endothelial/Pericyte Interactions [PDF]

Circulation Research, 2005
Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of vascular formation, stabilization, remodeling, and function.
Annika, Armulik, Alexandra, Abramsson, Christer, Betsholtz   +2 more
openaire   +2 more sources

Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]

, 2013
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C., Kelly, M. C., Kennedy-Lydon, T. M., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +4 more
core   +2 more sources

An Intact Kidney Slice Model to Investigate Vasa Recta Properties and Function in situ [PDF]

, 2012
Background: Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that pericytes can constrict/dilate descending vasa recta when vasoactive substances are ...
Agmon Y, Armulik A, Bogle RG, Bratosin D, C. Crawford, C. Sprott, C.M. Peppiatt-Wildman, Crawford C, Cupples WA, Dahlstrom A, Dietrich HH, Dunn KW, Hall AM, Hamilton NB, Holliger C, Horiuchi T, Hughes S, J. Munday, Jans D, Kawamura H, L. Sawbridge, Landis EM, MacPhee PJ, Mattson DL, Mattson DL, O’Connor PM, Pallone TL, Pallone TL, Pallone TL, Pallone TL, Pallone TL, Park F, Patzak A, Peppiatt CM, Praetorius HA, R.J. Unwin, Rhinehart K, Rhinehart KL, Roman RJ, S.S.P. Wildman, Shepro D, Silldorff EP, Silldorff EP, Silldorff EP, Sprague RS, T. Desai, T. Kennedy-Lydon, Thiel G, Whitehouse T, Wu DM, Zhang Z, Zhang Z   +51 more
core   +2 more sources

Pericytes: The lung-forgotten cell type

Frontiers in Physiology, 2023
Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal surface of microvessels, where they provide structural and biochemical support. Pericytes have been implicated in numerous lung diseases including pulmonary arterial hypertension (PAH) and allergic asthma due to their ability to differentiate into scar-forming ...
Annelise T. Garrison, Rebecca E. Bignold, Xinhui Wu, Xinhui Wu, Xinhui Wu, Jill R. Johnson   +5 more
openaire   +3 more sources

Age and diabetes related changes of the retinal capillaries: an ultrastructural and immunohistochemical study [PDF]

, 2015
Normal human aging and diabetes are associated with a gradual decrease of cerebral flow in the brain with changes in vascular architecture. Thickening of the capillary basement membrane and microvascular fibrosis are evident in the central nervous system
ARTICO, Marco, BATTAGLIONE, Ezio, BIANCHI, ENRICA, Feher, Janos, Kovacs, Illes, MAGLIULO, Giuseppe, Micera, Alessandra, ORLANDO, Maria Patrizia, PLATEROTI, Rocco, Ripandelli, Guido, TAURONE, SAMANTA   +10 more
core   +1 more source