Results 21 to 30 of about 86,775 (289)
Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target
Frontiers in Cellular Neuroscience, 2019 Pericytes are functional components of the neurovascular unit (NVU) that are located around the blood vessels, and their roles in the regulation of cerebral health and diseases has been reported.
Xiaojuan Su +8 more
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Emerging Role of Pericytes and Their Secretome in the Heart
Cells, 2021 Pericytes, as mural cells covering microvascular capillaries, play an essential role in vascular remodeling and maintaining vascular functions and blood flow.
Han Su +4 more
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Cells, 2023 Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as ...
Pengfei Li, Hongkuan Fan
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eLife, 2018 Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, most notably α-smooth muscle actin
Luis Alarcon-Martinez +7 more
doaj +1 more source
Targeting pericytes for neurovascular regeneration
Cell Communication and Signaling, 2019 Pericytes, as a key cellular part of the blood-brain barrier, play an important role in the maintenance of brain neurovascular unit. These cells participate in brain homeostasis by regulating vascular development and integrity mainly through secreting ...
Mohammad Hossein Geranmayeh +2 more
doaj +1 more source
Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]
, 2014 Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo +3 more
core +1 more source
Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]
, 2018 Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O. +11 more
core +1 more source
Neural pericytes: A genomic archival state programmed by CHromatin topology
European Journal of Cell Biology, 2022 Accumulating evidence suggests that mural pericytes, apart from stabilizing the associated microvessels, play additional roles in regeneration of local cellular elements.
Ramin M. Farahani
doaj +1 more source
RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]
, 2016 Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia +16 more
core +1 more source
Diabetes, 2008 OBJECTIVE— The mechanism underlying pericyte loss during incipient diabetic retinopathy remains controversial. Hyperglycemia induces angiopoietin-2 (Ang-2) transcription, which modulates capillary pericyte coverage. In this study, we assessed loss of pericyte subgroups and the contribution of Ang-2 to pericyte migration.
Frederick Pfister +8 more
openaire +1 more source