Results 41 to 50 of about 86,775 (289)

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target [PDF]

open access: yes, 2018
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years.
Abdel-Aziz   +431 more
core   +2 more sources

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells [PDF]

open access: yes, 2016
Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and ...
Carrasco-Avino, G   +4 more
core   +1 more source

Emerging key roles for P2X receptors in the kidney [PDF]

open access: yes, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E.   +3 more
core   +2 more sources

Pericytes synthesize renin

open access: yesWorld Journal of Nephrology, 2013
To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type (WT) and angiotensinogen deficient (AGT -/-) mice at different developmental ...
Alison C, Berg   +4 more
openaire   +2 more sources

Pericytes modulate endothelial sprouting [PDF]

open access: yesCardiovascular Research, 2013
Angiogenic sprouts arise from microvessels formed by endothelial cells (ECs) invested by pericytes (PCs). The aim of this study was to examine the role of PCs in angiogenic sprouting, an understudied phenomenon.We adapted a human EC spheroid model to examine PC effects on vascular endothelial growth factor-A-induced EC sprouting in vitro by using Bcl-2-
William G, Chang   +4 more
openaire   +2 more sources

Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury [PDF]

open access: yes, 2017
Ischemia-reperfusion injury (IRI) is a leading cause of AKI. This common clinical complication lacks effective therapies and can lead to the development of CKD.
Alimperti, Stella   +21 more
core   +1 more source

Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis

open access: yesiScience
Summary: Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung.
Ludivine Renaud   +4 more
doaj   +1 more source

Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-derived Pericytes

open access: yesCell Transplantation, 2020
Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential.
Vyacheslav Ogay   +15 more
doaj   +1 more source

Biology and function of pericytes in the vascular microcirculation

open access: yesAnimal Models and Experimental Medicine, 2023
Pericytes are the main cellular components of tiny arteries and capillaries. Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines, thus affecting the contraction and relaxation of ...
Yue Wu   +12 more
doaj   +1 more source

Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma [PDF]

open access: yes, 2018
Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type and for its rarity is poorly studied. The most common sites of metastatic disease in patients with intracranial HPT are the bone, liver, and lung, suggestive for an hematogenous ...
Carpino, Guido   +9 more
core   +3 more sources

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