Results 41 to 50 of about 106,411 (380)
The Role of Pericytes in Ischemic Stroke: Fom Cellular Functions to Therapeutic Targets
Frontiers in Molecular Neuroscience, 2022 Ischemic stroke (IS) is a cerebrovascular disease causing high rates of disability and fatality. In recent years, the concept of the neurovascular unit (NVU) has been accepted by an increasing number of researchers and is expected to become a new ...
Sheng-Yu Zhou +4 more
semanticscholar +1 more source
Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients
bioRxiv, 2021 A wide range of neurological manifestations have been associated with the development of COVID-19 following SARS-CoV-2 infection. However, the etiology of the neurological symptomatology is still largely unexplored.
M. Bocci +10 more
semanticscholar +1 more source
Cells, 2023 Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as ...
Pengfei Li, Hongkuan Fan
openaire +3 more sources
Targeting pericytes for neurovascular regeneration
Cell Communication and Signaling, 2019 Pericytes, as a key cellular part of the blood-brain barrier, play an important role in the maintenance of brain neurovascular unit. These cells participate in brain homeostasis by regulating vascular development and integrity mainly through secreting ...
Mohammad Hossein Geranmayeh +2 more
doaj +1 more source
Oxidative Medicine and Cellular Longevity, 2021 Diabetic retinopathy (DR) is a frequently occurring microvascular complication induced by long-term hyperglycemia. Pericyte-endothelial cell crosstalk is critical for maintaining vascular homeostasis and remodeling; however, the molecular mechanism ...
Lin Ye +7 more
semanticscholar +1 more source
Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]
, 2018 Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O. +11 more
core +1 more source
Contractile pericytes determine the direction of blood flow at capillary junctions
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Capillaries—the most abundant vessels in the circulatory system—deliver O2 and nutrients to all cells of the body. In the brain and retina, capillaries also act as a sensory web that detects neuronal activity.
Albert L. Gonzales +9 more
semanticscholar +1 more source
Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]
, 2014 Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo +3 more
core +1 more source
Neural pericytes: A genomic archival state programmed by CHromatin topology
European Journal of Cell Biology, 2022 Accumulating evidence suggests that mural pericytes, apart from stabilizing the associated microvessels, play additional roles in regeneration of local cellular elements.
Ramin M. Farahani
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Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia
Frontiers in Aging Neuroscience, 2020 Pericytes are unique, multi-functional mural cells localized at the abluminal side of the perivascular space in microvessels. Originally discovered in 19th century, pericytes had drawn less attention until decades ago mainly due to lack of specific ...
Maiko T Uemura +4 more
semanticscholar +1 more source