Results 71 to 80 of about 1,400 (132)

Nrg1 regulates cortical wiring and motor recovery upon traumatic injury

Frontiers in Cellular Neuroscience
IntroductionTraumatic brain injury (TBI) is a leading cause of disability, yet molecular mechanisms supporting cortical repair remain poorly defined. While Neuregulin 1 (Nrg1) is essential for cortical development, its role in traumatic cortical injury ...
Ana González-Manteiga, Ana González-Manteiga, Carmen Navarro-González, Carmen Navarro-González, Ángela Rodríguez-Prieto, Maria Vittoria Zavaglia, Pietro Fazzari   +6 more
doaj   +1 more source

Extracellular matrix of the central nervous system: from neglect to challenge [PDF]

, 2018
The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal ...
Dours-Zimmermann, María, Zimmermann, Dieter   +1 more
core  

A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells [PDF]

, 2013
BACKGROUND: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro.
Adolfo López de Munain, Ander Izeta, Antonio G García, Fabio Cavaliere, José Álava, Marcos Maroto, Neia Naldaiz-Gastesi, Patricia García-Parra   +7 more
core   +3 more sources

Cerebellar plasticity and associative memories are controlled by perineuronal nets. [PDF]

, 2020
Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are prominently expressed around neurons of the deep cerebellar nuclei (DCN)
Boele, Henk-Jan, Broersen, Robin, Canto, Cathrin B, Carulli, Daniela, de Vries, Sharon, de Waal, Matthijs, de Winter, Fred, De Zeeuw, Chris I, Mešković, Maja, Muir, Elizabeth M, Verhaagen, Joost   +10 more
core   +6 more sources

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 8, August 2025.
Targeting ECM dysregulation: therapeutic strategies for disease intervention. Dysregulated ECM composition and biomechanics contribute to disease pathogenesis in cancer and fibrotic disorders. Physical modulation: Nanomedicine‐based strategies tune ECM physical properties (e.g., density, stiffness) to enhance drug penetration and therapeutic efficacy ...
Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Molekuláris mechanizmusok vizsgálata a vestibularis rendszer fejlődése, regenerációja és plaszticitása során = Investigation of molecular mechanisms in the development, regeneration and plasticity of vestibular system [PDF]

, 2012
Csirkeembriók gerincvelőjében és agytörzsében kimutattuk, hogy a neuronok körüli, extracellularis matrixban (ECM) gazdag perineuronalis háló (PNN) az embrionális életben megjelenik, míg az emlősökben csak postnatalisan alakul ki.
Bácskai, Tímea, Deák, Ádám, Felszeghy, Szabolcs, Halasi, Gábor György, Matesz, Klára, Mészár, Zoltán, Módis, László, Rácz, Éva, Székely, György   +8 more
core  

Common miRNAs, Genes, and Regulatory Pathways in Alzheimer's Disease and Type 2 Diabetes Mellitus: An Integrative Analysis of Systematic Reviews, Bioinformatics and Data Mining

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are frequent conditions affecting older adults, with evidence suggesting a higher predisposition for AD in diabetic patients. MicroRNAs (miRNAs) are proposed as regulators of gene expression in the mutual pathways among these diseases. In this study, the T‐cell receptor–RAS signaling (TCR‐RAS)
Lívia Cristina Ribeiro Teixeira, Jessica Diniz Pereira, Izabela Mamede, Paulo Caramelli, Vítor Corrêa Silva, Adriano Alonso Veloso, Marcelo Rizzatti Luizon, Karina Braga Gomes   +7 more
wiley   +1 more source

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

Neurobiology of Disease
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a trigger
Sang Won Cheung, Emily F. Willis, David G. Simmons, Mark C. Bellingham, Peter G. Noakes   +4 more
doaj   +1 more source

Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds. [PDF]

, 2012
Mechanisms for the evolution of convergent behavioral traits are largely unknown. Vocal learning is one such trait that evolved multiple times and is necessary in humans for the acquisition of spoken language.
Horita, H, Jarvis, ED, Kobayashi, M, Liu, WC, Oka, K, Wada, K   +5 more
core   +4 more sources

Postoperative loss of perineuronal nets in the hippocampal CA1 region results in memory consolidation deficits

Brain Research Bulletin
Postoperative cognitive dysfunction (POCD) is a common postoperative neurological complication, with memory consolidation deficits being one of its prominent features.
Zun-sai Feng, Jiang-nan Wu, Gui-cheng Wang, Zi-qing Xu, Yan-jing Guo, Shi-yu Hao, Gong-ming Wang, Meng-yuan Zhang   +7 more
doaj   +1 more source