Results 1 to 10 of about 2,852 (175)
Perineuronal nets stabilize the grid cell network [PDF]
Nature Communications, 2021 Perineuronal nets may stabilize synaptic connections. Here, the authors show that removal of perineuronal nets disrupts both the temporal and spatial organization of grid cell firing.
Ane Charlotte Christensen +7 more
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Shock-Induced Damage Mechanism of Perineuronal Nets [PDF]
Biomolecules, 2021 The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud +3 more
doaj +4 more sources
Caught in the Net: Perineuronal Nets and Addiction [PDF]
Neural Plasticity, 2016 Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker +2 more
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Perineuronal Nets and CNS Plasticity and Repair [PDF]
Neural Plasticity, 2016 The extracellular matrix (ECM) of the nervous system regulates numerous events during development, from neurogenesis and gliogenesis to circuitry formation, as well as in adulthood, affecting damage responses, plasticity, and regeneration. Substantial changes in the quantity and the composition of ECM occur during development.
Daniela Carulli +2 more
doaj +6 more sources
Cross-species conservation in the regulation of parvalbumin by perineuronal nets [PDF]
Frontiers in Neural Circuits, 2023 Parvalbumin (PV) neurons play an integral role in regulating neural dynamics and plasticity. Therefore, understanding the factors that regulate PV expression is important for revealing modulators of brain function. While the contribution of PV neurons to
Angela S. Wang +12 more
doaj +2 more sources
The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning [PDF]
BiologyEvidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that ...
Bernard G. Schreurs +2 more
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Perineuronal nets in the developing brain: implications for neurodevelopmental disorders [PDF]
Molecular BrainHere, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies.
Jennifer M. Ackerman +3 more
doaj +2 more sources
Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets [PDF]
Neurobiology of StressPerineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity.
Jhoan S. Aguilar, Amy W. Lasek
doaj +2 more sources
Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit? [PDF]
CellsPerineuronal nets (PNNs), a specialized form of extra cellular matrix (ECM), surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure.
Varda Lev-Ram +14 more
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Circadian Rhythms of Perineuronal Net Composition [PDF]
eneuro, 2020 Abstract Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs
Harry Pantazopoulos +10 more
openaire +3 more sources