Fast oscillatory activity in the anterior cingulate cortex: dopaminergic modulation and efect of perineuronal net loss [PDF]
Frontiers in Cellular Neuroscience, 2014 Dopamine release in the prefrontal cortex plays a critical role in cognitive function such as working memory, attention and planning. Dopamine exerts complex modulation on excitability of pyramidal neurons and interneurons, and regulates excitatory and ...
Pascal eSteullet +2 more
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Cross-species conservation in the regulation of parvalbumin by perineuronal nets [PDF]
Frontiers in Neural Circuits, 2023 Parvalbumin (PV) neurons play an integral role in regulating neural dynamics and plasticity. Therefore, understanding the factors that regulate PV expression is important for revealing modulators of brain function. While the contribution of PV neurons to
Angela S. Wang +12 more
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The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning [PDF]
BiologyEvidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that ...
Bernard G. Schreurs +2 more
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Perineuronal nets in the developing brain: implications for neurodevelopmental disorders [PDF]
Molecular BrainHere, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies.
Jennifer M. Ackerman +3 more
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Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets [PDF]
Neurobiology of StressPerineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity.
Jhoan S. Aguilar, Amy W. Lasek
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Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit? [PDF]
CellsPerineuronal nets (PNNs), a specialized form of extra cellular matrix (ECM), surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure.
Varda Lev-Ram +14 more
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Perineuronal nets stabilize the grid cell network
Nature Communications, 2021 Perineuronal nets may stabilize synaptic connections. Here, the authors show that removal of perineuronal nets disrupts both the temporal and spatial organization of grid cell firing.
Ane Charlotte Christensen +7 more
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Neural Regeneration Research, 2022 Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of ...
Agnes Magyar +5 more
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Shock-Induced Damage Mechanism of Perineuronal Nets
Biomolecules, 2021 The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud +3 more
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Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses. [PDF]
PLoS ONE, 2011 Structural remodeling or repair of neural circuits depends on the balance between intrinsic neuronal properties and regulatory cues present in the surrounding microenvironment.
Simona Foscarin +7 more
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