Results 91 to 100 of about 5,812 (218)

AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. [PDF]

PLoS ONE, 2016
Epilepsy is a serious brain disorder with diverse seizure types and epileptic syndromes. AMPA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoquinoxaline-2,3-dione (NBQX) attenuates spontaneous recurrent seizures in rats.
Wen Chen, Yan-Shuang Li, Jing Gao, Xiao-Ying Lin, Xiao-Hong Li   +4 more
doaj   +1 more source

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source

Enhancement of visual cortex plasticity by dark exposure [PDF]

, 2017
Dark rearing is known to delay the time course of the critical period for ocular dominance plasticity in the visual cortex. Recent evidence suggests that a period of dark exposure (DE) may enhance or reinstate plasticity even after closure of the ...
Erchova, Irina, Longo, Valentina, Sengpiel, Frank, Vasalauskaite, Asta   +3 more
core   +1 more source

The Functional Epididymal Amyloid Cystatin‐Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
This study investigated if the epididymal amyloid CRES (cystatin‐related epididymal spermatogenic) is present in the male and female mammalian brain. CRES is expressed by hippocampal astrocytes, CA2 and CA3 neurons, and exhibits amyloid properties in the extracellular matrix.
Alejandra Gomez, Uyen T. Tran, Petar N. Grozdanov, Gail A. Cornwall   +3 more
wiley   +1 more source

Guiding Management of Bethesda V Thyroid Nodules: The Role of Molecular Testing

Clinical Endocrinology, Volume 104, Issue 1, Page 67-74, January 2026.
ABSTRACT Objective The 2023 Bethesda System update introduced molecular testing as a management option for Bethesda V cytology nodules, aiming to guide surgical decision‐making. This study investigates the correlation between molecular profiling and malignancy aggressiveness. Design We conducted a retrospective multicenter study involving patients with
Idit Tessler, Grégoire B. Morand, Nir A. Gecel, Arad Dotan, Tzahi Yamin, Eran E. Alon, Richard J. Payne, Galit Avior   +7 more
wiley   +1 more source

Perineuronal nets protect fast-spiking interneurons against oxidative stress [PDF]

Proceedings of the National Academy of Sciences, 2013
A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony during various sensory and cognitive tasks. The high metabolic requirements of these fast-spiking cells may render them susceptible to redox dysregulation and oxidative stress.
Cabungcal, Jan-Harry, Steullet, Pascal, Morishita, Hirofumi, Kraftsik, Rudolf, Cuenod, Michel, Hensch, Takao, Do, Kim Q.   +6 more
openaire   +4 more sources

MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex [PDF]

, 2015
Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome, an autism spectrum-associated disorder with a host of neurological and sensory symptoms, but the pathogenic mechanisms remain elusive.
Cang, J., Huang, Z. J., Krishnan, K., Lu, J., Maffei, A., Wang, B. S., Wang, L.   +6 more
core   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, Volume 9, Issue 12, December 2025.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

EBioMedicine, 2020
Background: Microglia, the brain's principal immune cell, are increasingly implicated in Alzheimer's disease (AD), but the molecular interfaces through which these cells contribute to amyloid beta (Aβ)-related neurodegeneration are unclear.
Joshua D. Crapser, Elizabeth E. Spangenberg, Rocio A. Barahona, Miguel A. Arreola, Lindsay A. Hohsfield, Kim N. Green   +5 more
doaj   +1 more source

Chondroitinase ABC-I and -II linked chitosan microbeads increase neurtire length in CSPG-enriched astrocyte culture [PDF]

, 2014
Poster Presentation - Theme 5: NeuroscienceAfter spinal cord injury, axonal regrowth is often restricted due to upregulation of chondroitin sulfate proteoglycans (CSPGs) at the lesion site.
Kwok, LF, Shum, DKY
core