Results 101 to 110 of about 5,812 (218)

Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis [PDF]

, 2016
S1 IHC in pre-symptomatic and clinical-onset EAE: PV+ cell counts, PNN counts, and Iba-1+ microglia counts. A) Representative fluorescence photomicrographs of PV+ staining (low-mag) in S1 from control (CFA) and EAE animals at the pre-symptomatic stage (7–
Bradley J. Kerr, Fred Colbourne, Glen Baker, Gustavo Tenorio, Ian Winship, Jayalakshmi Caliaperumal, Jee Su Suh, John W. Paylor, Liam E. Potter   +8 more
core   +4 more sources

The critical role of extracellular matrix in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background In central nervous system, all components are enveloped by the extracellular matrix (ECM), regulating microenvironmental homeostasis and neuronal development. The condensed cartilage‐like ECM called perineuronal nets (PNNs), mainly surrounding parvalbumin‐expressing (PV+) fast‐firing GABAergic interneurons, are crucial to synaptic ...
Xiaolei Zhu, Zhen Lan, Yun Xu
wiley   +1 more source

Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit

Neural Regeneration Research, 2015
We have previously found that unilateral labyrinthectomy is accompanied by modification of hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of rats and the time course of subsequent reorganization of ...
Botond Gaal, Einar Örn Jóhannesson, Amit Dattani, Agnes Magyar, Ildikó Wéber, Clara Matesz   +5 more
doaj   +1 more source

A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells [PDF]

, 2013
BACKGROUND: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro.
Adolfo López de Munain, Ander Izeta, Antonio G García, Fabio Cavaliere, José Álava, Marcos Maroto, Neia Naldaiz-Gastesi, Patricia García-Parra   +7 more
core   +3 more sources

Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity

Ibrain, Volume 11, Issue 4, Page 403-421, Winter 2025.
Synaptic adhesion molecules (SAM) are essential for the formation, maturation, function, plasticity, and assembly of synaptic connections, all critical for normal neurodevelopment. Excessive exposure to neurotoxic metals during development could disrupt the developing brain and potentially lead to neurodevelopmental disorders (NDDs).
Toheeb O. Oyerinde, Victor E. Anadu, Tobiloba S. Olajide, Ileje I. Ukwubile, Olayemi K. Ijomone, Kingsley A. Iteire, Michael Aschner, Omamuyovwi M. Ijomone   +7 more
wiley   +1 more source

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human

Frontiers in Physiology, 2019
Preterm brain injury, occurring in approximately 30% of infants born <32 weeks gestational age, is associated with an increased risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder ...
Helen B. Stolp, Helen B. Stolp, Bobbi Fleiss, Bobbi Fleiss, Bobbi Fleiss, Yoko Arai, Veena Supramaniam, Regina Vontell, Regina Vontell, Sebastian Birtles, Abi G. Yates, Abi G. Yates, Ana A. Baburamani, Claire Thornton, Claire Thornton, Mary Rutherford, A. David Edwards, Pierre Gressens, Pierre Gressens   +18 more
doaj   +1 more source

Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. [PDF]

, 2015
Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions in these processes underlie many neurodevelopmental abnormalities.
Amaral, David G, Bakken, Trygve E, Bennett, Jeffrey L, Bernard, Amy, Bertagnolli, Darren, Geschwind, Daniel H, Lee, Chang-Kyu, Lein, Ed S, Luo, Rui, Miller, Jeremy A, Parikshak, Neelroop N, Smith, Kimberly A, Sunkin, Susan M   +12 more
core   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

JOR SPINE, Volume 8, Issue 4, December 2025.
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley   +1 more source

Semaphorin3A, associated with perineuronal nets, regulates the development of the maturation of the central vestibular circuitry [PDF]

, 2014
Poster Presentation - Theme 5: NeuroscienceDuring the formative period of neural circuits, perineuronal nets (PN) are established to restrict plasticity of the circuit.
Chan, YS, Kwan, PY, Ma, CW, Shum, DKY
core  

Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2 [PDF]

, 2017
Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) chain. In cartilage, CS plays important roles as the main component of the extracellular matrix (ECM), existing as side chains of the major cartilage proteoglycan, aggrecan.
Fuseya Sayaka, Hagiwara Kozue, Kimata Koji, Kiyohara Katsue, Kudo Takashi, Narimatsu Hisashi, Okada Risa, Sato Takashi, Shimbo Miki, Suzuki Riku, Takahashi Satoru, Tsunakawa Yuki, Wakui Hiromasa, Watanabe Hideto, 岡田 理沙, 工藤 崇, 高橋 智   +16 more
core   +2 more sources