Results 11 to 20 of about 5,812 (218)
Caught in the Net: Perineuronal Nets and Addiction [PDF]
Neural Plasticity, 2016 Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker +2 more
doaj +4 more sources
Perineuronal Nets and CNS Plasticity and Repair [PDF]
Neural Plasticity, 2016 The extracellular matrix (ECM) of the nervous system regulates numerous events during development, from neurogenesis and gliogenesis to circuitry formation, as well as in adulthood, affecting damage responses, plasticity, and regeneration. Substantial changes in the quantity and the composition of ECM occur during development.
Daniela Carulli +2 more
doaj +6 more sources
Correction to "Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's disease". [PDF]
Alzheimers DementAlzheimer's &Dementia, Volume 22, Issue 1, January 2026.
europepmc +2 more sources
Circadian Rhythms of Perineuronal Net Composition [PDF]
eneuro, 2020 Abstract Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs
Harry Pantazopoulos +10 more
openaire +3 more sources
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders. PNN development and maintenance is necessary for a number of processes within the CNS, including regulation of ...
Teresa H. Wen +6 more
openaire +5 more sources
Perineuronal net degradation in epilepsy [PDF]
Epilepsia, 2015 SummaryObjectiveWe previously reported loss of perineuronal net (PN) immunohistochemical staining around parvalbumin‐positive interneurons in the hippocampus of rats after an episode of status epilepticus (SE). We hypothesized that the loss of thePNcould alter seizure susceptibility and that matrix metalloproteinases (MMPs) were candidates for ...
Elyse K. Rankin‐Gee +5 more
openaire +2 more sources
Primary cilia are required for the persistence of memory and stabilization of perineuronal nets
iScience, 2021 Summary: It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales.
Vladimir Jovasevic +7 more
doaj +1 more source
iScience, 2023 Summary: In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of ...
Takehiro Kudo +10 more
doaj +1 more source
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory [PDF]
, 2017 Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory.
Foscarin, S +3 more
core +4 more sources
Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Cells, 2021 The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj +1 more source