Results 21 to 30 of about 5,812 (218)

Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment [PDF]

Alzheimers Dement
Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million people worldwide. Key pathological features of AD include the accumulation of beta‐amyloid plaques and hyperphosphorylated tau tangles.
Chaunsali L.
europepmc   +2 more sources

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long-term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets. [PDF]

J Anat
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Szabó FP, Sigutova V, Schneider AM, Hoerder-Suabedissen A, Molnár Z.   +4 more
europepmc   +2 more sources

Perineuronal Net Receptor PTPσ Regulates Retention of Memories [PDF]

Frontiers in Synaptic Neuroscience, 2021
Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in long-term preservation of newly acquired skills and information.
Lesnikova Angelina, Biojone Caroline, Castren Eero, Casarotto Plinio, Moliner Rafael, Fred Senem Merve   +5 more
openaire   +4 more sources

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. [PDF]

, 2017
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes.
Becker, Albert, Friedman, Alon, Gu, Feng, Heinemann, Uwe, KAUFER, daniela, Kim, Soo, Lippmann, Kristina, Milikovsky, Dan, Morrissey, Christapher, Parada, Isabel, Prince, David, Senatorov, Vladimir, Vazquez, Oscar   +12 more
core   +5 more sources

Perineuronal Nets and Metal Cation Concentrations in the Microenvironments of Fast-Spiking, Parvalbumin-Expressing GABAergic Interneurons: Relevance to Neurodevelopment and Neurodevelopmental Disorders

Biomolecules, 2021
Because of their abilities to catalyze generation of toxic free radical species, free concentrations of the redox reactive metals iron and copper are highly regulated.
Jessica A. Burket, Jason D. Webb, Stephen I. Deutsch   +2 more
doaj   +1 more source

Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain

Frontiers in Neuroanatomy, 2022
Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura, Kazuchika Nishitsuji, Midori Ikezaki, Tomoya O. Akama, Yoshito Ihara, Fabrice Allain, Kenji Uchimura   +6 more
doaj   +1 more source

A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication [PDF]

, 2017
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Arranz, Baig, Banerjee, Baranova, Barritt, Beebe, Beurdeley, Blosa, Bradbury, Brakebusch, Brückner, Brückner, Bukalo, Bukalo, Cabungcal, Caillard, Carstens, Carulli, Carulli, Carulli, Chang, Cheah, Corvetti, Coulson-Thomas, Dauth, Day, de Winter, Deepa, Deepa, Dick, Dityatev, Donato, Favuzzi, Foscarin, Frischknecht, Galtrey, Galtrey, Geissler, Giamanco, Gogolla, Grøndahl, Gu, Gurevicius, Happel, Heleen M. van 't Spijker, Hensch, Hisaoka, Hylin, Härtig, Härtig, Jansen, Jessica C. F. Kwok, Kochlamazashvili, Kwok, Kwok, Lafarga, Lander, Lee, Lensjø, Lensjø, Mabuchi, Matthews, McRae, Miyata, Miyata, Miyata, Morawski, Morawski, Morawski, Morikawa, Orlando, Pantazopoulos, Pelkey, Pizzorusso, Pizzorusso, Romberg, Rossier, Shinozaki, Smith, Spatazza, Spreafico, Steullet, Sugiyama, Suttkus, Suzuki, Vo, Wang, Yamada, Ye   +88 more
core   +2 more sources

Diverse functions of perineuronal nets

Acta Neurobiologiae Experimentalis, 2009
Perineuronal nets represent well-organised components of the extracellular matrix, which are surrounding cell bodies, dendrites, and axon segments of a particular class of neurones as well as forming lattice-like structures. The role of perineuronal nets is not fully elucidated yet.
Magdalena, Karetko, Jolanta, Skangiel-Kramska   +1 more
openaire   +2 more sources

Longitudinal in vivo imaging of perineuronal nets

Neurophotonics, 2023
Perineuronal nets (PNNs) are extracellular matrix structures implicated in learning, memory, information processing, synaptic plasticity, and neuroprotection. However, our understanding of mechanisms governing the evidently important contribution of PNNs to central nervous system function is lacking.
Benbenishty, Amit, Peled-Hajaj, Shany, Krishnaswamy, Venkat Raghavan, Har-Gil, Hagai, Havusha-Laufer, Sapir, Ruggiero, Antonella, Slutsky, Inna, Blinder, Pablo, Sagi, Irit   +8 more
openaire   +2 more sources

N-acetylgalactosamine positive perineuronal nets in the saccade-related-part of the cerebellar fastigial nucleus do not maintain saccade gain. [PDF]

PLoS ONE, 2014
Perineuronal nets (PNNs) accumulate around neurons near the end of developmental critical periods. PNNs are structures of the extracellular matrix which surround synaptic contacts and contain chondroitin sulfate proteoglycans.
Adrienne Mueller, Adam Davis, Steven S Carlson, Farrel R Robinson   +3 more
doaj   +1 more source