Results 21 to 30 of about 2,852 (175)
Biomolecules, 2021 Because of their abilities to catalyze generation of toxic free radical species, free concentrations of the redox reactive metals iron and copper are highly regulated.
Jessica A. Burket +2 more
doaj +1 more source
Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain
Frontiers in Neuroanatomy, 2022 Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura +6 more
doaj +1 more source
Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long-term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets. [PDF]
J AnatChronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Szabó FP +4 more
europepmc +2 more sources
Diverse functions of perineuronal nets
Acta Neurobiologiae Experimentalis, 2009 Perineuronal nets represent well-organised components of the extracellular matrix, which are surrounding cell bodies, dendrites, and axon segments of a particular class of neurones as well as forming lattice-like structures. The role of perineuronal nets is not fully elucidated yet.
Magdalena, Karetko +1 more
openaire +2 more sources
Longitudinal in vivo imaging of perineuronal nets
Neurophotonics, 2023 Perineuronal nets (PNNs) are extracellular matrix structures implicated in learning, memory, information processing, synaptic plasticity, and neuroprotection. However, our understanding of mechanisms governing the evidently important contribution of PNNs to central nervous system function is lacking.
Benbenishty, Amit +8 more
openaire +2 more sources
N-acetylgalactosamine positive perineuronal nets in the saccade-related-part of the cerebellar fastigial nucleus do not maintain saccade gain. [PDF]
PLoS ONE, 2014 Perineuronal nets (PNNs) accumulate around neurons near the end of developmental critical periods. PNNs are structures of the extracellular matrix which surround synaptic contacts and contain chondroitin sulfate proteoglycans.
Adrienne Mueller +3 more
doaj +1 more source
Perineuronal Net Dynamics in the Pathophysiology of Epilepsy [PDF]
Epilepsy Currents, 2021 Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Lata Chaunsali +2 more
openaire +3 more sources
Releasing Addiction Memories Trapped in Perineuronal Nets [PDF]
Trends in Genetics, 2018 Drug addiction can be conceptualized at a basic level as maladaptive learning and memory. Addictive substances elicit changes in brain circuitry involved in reward, cognition, and emotional state, leading to the formation and persistence of strong drug-associated memories that lead to craving and relapse.
Amy W. Lasek, Hu Chen, Wei-Yang Chen
openaire +2 more sources
Perineuronal Nets: Subtle Structures with Large Implications
The Neuroscientist, 2022 Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround the soma and proximal dendrites of certain neurons in the central nervous system, particularly parvalbumin-expressing interneurons. Their appearance overlaps the maturation of neuronal circuits and the closure of critical periods in different regions of the ...
Héctor Carceller +3 more
openaire +5 more sources
Neural Plasticity, 2016 Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites.
Adrienne L. Mueller +4 more
doaj +1 more source