Results 31 to 40 of about 5,812 (218)
A „ruha” teszi a neuront – az extracelluláris mátrix különböző megjelenési formái gerincesek központi idegrendszerében [PDF]
, 2013 Introduction: Extracellular matrix is a key component of most connective tissues. For decades, the presence of this chemically heterogeneous interface has been largely unaddressed or even denied in the central nervous system.
Gáti, Georgina, Lendvai, Dávid
core +1 more source
Perineuronal Net Dynamics in the Pathophysiology of Epilepsy [PDF]
Epilepsy Currents, 2021 Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Lata Chaunsali +2 more
openaire +3 more sources
Perineuronal nets enhance the excitability of fast-spiking neurons [PDF]
, 2016 © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in eNeuro 3 (2016): e0112-16.2016, doi:10.1523/ENEURO.0112-16.2016.Perineuronal nets (PNNs) are ...
Balmer, Timothy
core +1 more source
Releasing Addiction Memories Trapped in Perineuronal Nets [PDF]
Trends in Genetics, 2018 Drug addiction can be conceptualized at a basic level as maladaptive learning and memory. Addictive substances elicit changes in brain circuitry involved in reward, cognition, and emotional state, leading to the formation and persistence of strong drug-associated memories that lead to craving and relapse.
Amy W. Lasek, Hu Chen, Wei-Yang Chen
openaire +2 more sources
Perineuronal Nets: Subtle Structures with Large Implications
The Neuroscientist, 2022 Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround the soma and proximal dendrites of certain neurons in the central nervous system, particularly parvalbumin-expressing interneurons. Their appearance overlaps the maturation of neuronal circuits and the closure of critical periods in different regions of the ...
Héctor Carceller +3 more
openaire +5 more sources
Neural Plasticity, 2016 Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites.
Adrienne L. Mueller +4 more
doaj +1 more source
Frontiers in Neuroanatomy, 2019 Environmental enrichment can dramatically affect both the development and function of neural circuits. This is accomplished, at least in part, by the regulation of inhibitory cellular networks and related extracellular matrix glycoprotein structures ...
Angela May O’Connor +5 more
doaj +1 more source
Dynamics of perineuronal nets over amphibian metamorphosis
Journal of Comparative Neurology, 2020 Abstract Extracellular matrix materials known as perineuronal nets (PNNs) have been shown to have remarkable consequences for the maturation of neural circuits and stabilization of behavior. It has been proposed that, due to the possibly long‐lived biochemical nature of their components, PNNs may be an important substrate by which ...
Jacob A. Edwards +2 more
openaire +3 more sources
Chondroitin sulfates and their binding molecules in the central nervous system [PDF]
, 2017 Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a ...
Djerbal, L, Kwok, JCF, Lortat-Jacob, H
core +3 more sources
Perineuronal nets: Cruise from a honeycomb to the safety nets
Brain Research Bulletin, 2022 The extracellular matrix (ECM) is a significant component of the brain, constituting up to 20 % of the brain volume and perform multifarious functions during development, maturation and regeneration of the central nervous system (CNS). ECM molecules assemble systematically to form a relatively rigid and unique lattice-like structure, known as ...
Urmilla John, Nisha Patro, Ishan Patro
openaire +2 more sources