Results 41 to 50 of about 2,852 (175)
Otx2-PNN Interaction to Regulate Cortical Plasticity
Neural Plasticity, 2016 The ability of the environment to shape cortical function is at its highest during critical periods of postnatal development. In the visual cortex, critical period onset is triggered by the maturation of parvalbumin inhibitory interneurons, which ...
Clémence Bernard, Alain Prochiantz
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Component-specific reduction in perineuronal nets in senescence-accelerated mouse strains
IBRO Neuroscience Reports, 2023 With increased life expectancy, age-related diseases are a significant health concern in Western societies. Animal models (e.g., rodents) have been used to understand age-related changes in brain function—particularly through the senescence-accelerated ...
Hiroshi Ueno +7 more
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Perineuronal nets affect memory and learning after synapse withdrawal
Translational Psychiatry, 2022 Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models.
Jiri Ruzicka +6 more
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Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex
IBRO Reports, 2018 Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed
Hiroshi Ueno +9 more
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Regulation of the E/I-balance by the neural matrisome
Frontiers in Molecular Neuroscience, 2023 In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main ...
Cornelius Mueller-Buehl +3 more
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Perineuronal Nets and Their Role in Synaptic Homeostasis [PDF]
International Journal of Molecular Sciences, 2019 Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure is still not known in detail, surround cell bodies and dendrites, which leaves free space for synapses to come into contact.
Mateusz Bosiacki +6 more
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Nature Communications, 2018 Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.
Bhanu P. Tewari +5 more
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Advanced Science, EarlyView.Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat +6 more
wiley +1 more source
Journal of Experimental Neuroscience, 2019 The neuroplasticity hypothesis of depression proposes that major depressive disorders are related to decreased hippocampal and cortical neural plasticity, which is reversed by antidepressant treatment.
Gianfilippo Coppola +3 more
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Loss of Perineuronal Net in ME7 Prion Disease [PDF]
Journal of Neuropathology & Experimental Neurology, 2008 Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma ...
Franklin, SL +3 more
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