Results 51 to 60 of about 2,852 (175)
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, EarlyView.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
WFA-labeled perineuronal nets in the macaque claustrum [PDF]
Claustrum, 2018 The claustrum (CLA) has been discussed as central to integrated conscious percepts, although recent evidence has emphasized a role in detecting sensory novelty or in amplifying correlated cortical inputs.We report that many neurons in the macaque CLA are ensheathed in perineuronal nets (PNNs), which contribute to synaptic stability and enhance neuronal
Mihovil Pletikos, Kathleen S. Rockland
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2014 Dopamine release in the prefrontal cortex plays a critical role in cognitive function such as working memory, attention and planning. Dopamine exerts complex modulation on excitability of pyramidal neurons and interneurons, and regulates excitatory and ...
Pascal eSteullet +2 more
doaj +1 more source
Influence of enriched environment on viral encephalitis outcomes: behavioral and neuropathological changes in albino Swiss mice. [PDF]
PLoS ONE, 2011 An enriched environment has previously been described as enhancing natural killer cell activity of recognizing and killing virally infected cells. However, the effects of environmental enrichment on behavioral changes in relation to virus clearance and ...
Aline Andrade de Sousa +11 more
doaj +1 more source
From Lobectomy to Completion Thyroidectomy: A Cohort Study and Systematic Review
Clinical Endocrinology, EarlyView.ABSTRACT Introduction The suggested management of thyroid cancer has been revised in the 2015 American Thyroid Association Management Guidelines, suggesting thyroid lobectomy alone for low‐risk thyroid cancer. However, precise patient selection is essential to identify who may need completion thyroidectomy (CT), avoiding the burden of a second surgery.
Idit Tessler +7 more
wiley +1 more source
Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay
Molecular BrainAerobic exercise has many effects on brain function, particularly at the hippocampus. Exercise has been shown to increase the rate of adult neurogenesis within the dentate gyrus and decrease the density of perineuronal nets in area CA1.
Dylan J. Terstege +3 more
doaj +1 more source
Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity [PDF]
The Journal of Neuroscience, 2016 Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and
Sorg, Barbara A +6 more
openaire +6 more sources
Early adversity and the comorbidity between metabolic disease and psychopathology
The Journal of Physiology, EarlyView.Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas +1 more
wiley +1 more source
Perineuronal nets in HVC and plasticity in male canary song.
PLoS ONE, 2021 Songbirds learn their vocalizations during developmental sensitive periods of song memorization and sensorimotor learning. Some seasonal songbirds, called open-ended learners, recapitulate transitions from sensorimotor learning and song crystallization ...
Gilles Cornez +7 more
doaj +1 more source
Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder
Brain Sciences, 2023 Autism spectrum disorder (ASD) is associated with neurodevelopmental alterations, including atypical forebrain cellular organization. Mutations in several ASD-related genes often result in cerebral cortical anomalies, such as the abnormal developmental ...
Tanya Gandhi +4 more
doaj +1 more source