Results 51 to 60 of about 5,812 (218)
Perineuronal Nets in Spinal Motoneurones: Chondroitin Sulphate Proteoglycan around Alpha Motoneurones [PDF]
, 2018 Perineuronal nets (PNNs) are extracellular matrix structures surrounding neuronal sub-populations throughout the central nervous system, regulating plasticity.
Asher +4 more
core +2 more sources
Molecular and cellular aspects of plasticity after neural injury [PDF]
, 2008 This review focuses on our effort to address plasticity of the nervous system after neural injury. We have used different animal models to examine cellular mechanisms of plasticity underlying the pathological and repair processes.
Chan, YS, Chen, LW, Shum, DKY, Yung, KKL
core +1 more source
Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex
IBRO Reports, 2018 Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed
Hiroshi Ueno +9 more
doaj +1 more source
Perineuronal nets affect memory and learning after synapse withdrawal
Translational Psychiatry, 2022 Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models.
Jiri Ruzicka +6 more
doaj +1 more source
Regulation of the E/I-balance by the neural matrisome
Frontiers in Molecular Neuroscience, 2023 In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main ...
Cornelius Mueller-Buehl +3 more
doaj +1 more source
Cocaine-induced plasticity in the cerebellum of sensitised mice [PDF]
, 2015 Rationale Prior research has accumulated a substantial amount of evidence on the ability of cocaine to produce short- and long-lasting molecular and structural plasticity in the corticostriatal-limbic circuitry. However, traditionally, the cerebellum
Carbó Gas, María +8 more
core +1 more source
Perineuronal Nets and Their Role in Synaptic Homeostasis [PDF]
International Journal of Molecular Sciences, 2019 Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure is still not known in detail, surround cell bodies and dendrites, which leaves free space for synapses to come into contact.
Mateusz Bosiacki +6 more
openaire +2 more sources
Nature Communications, 2018 Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.
Bhanu P. Tewari +5 more
doaj +1 more source
A Periaxonal Net in the Zebrafish Central Nervous System [PDF]
, 2003 We produced a monoclonal antibody, named A20, which specifically recognizes a 35 kDa protein and stains myelinated axons in zebrafish brain. The A20 antigen is located at the outside of the myelin layer of large axons, and comprises a fine meshwork ...
Alfei +19 more
core +1 more source
Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism [PDF]
, 2016 Background A reduction of the number of parvalbumin (PV)-immunoreactive (PV⁺) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK
Filice, Federica +4 more
core +1 more source