Results 61 to 70 of about 5,812 (218)

Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

Trends in Neurosciences, 2019
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key
Reichelt, Amy C., Hare, Dominic J., Bussey, Timothy J., Saksida, Lisa M.   +3 more
openaire   +4 more sources

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source

Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke. [PDF]

, 2013
Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost ...
Carmichael, S Thomas, Moshayedi, Pouria
core   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

A Further Analysis and Commentary on: Profiling Changes in Cortical Astroglial Cells Following Chronic Stress

Journal of Experimental Neuroscience, 2019
The neuroplasticity hypothesis of depression proposes that major depressive disorders are related to decreased hippocampal and cortical neural plasticity, which is reversed by antidepressant treatment.
Gianfilippo Coppola, Gareth M Rurak, Stephanie Simard, Natalina Salmaso   +3 more
doaj   +1 more source

Loss of Perineuronal Net in ME7 Prion Disease [PDF]

Journal of Neuropathology & Experimental Neurology, 2008
Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma ...
Franklin, SL, Love, S, Greene, JRT, Betmouni, S   +3 more
openaire   +3 more sources

Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. [PDF]

, 2017
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and high-frequency neuronal synchronization.
A A Grace, A Gokhale, A Kulak, A Reif, A-S LaMantia, AJ Sharp, AR Santos, AW Johnson, B Rodriguez-Santiago, B Zikopoulos, C Bernard, C Kaur, C Le Magueresse, CA Cea-Del Rio, CL Beasley, CZ Wang, D Mehta, DA Lewis, DA Rossignol, DJ Lodge, DT Balu, DW Meechan, E Rees, EK Lucas, F Donato, F Filice, F Fonnum, F Longordo, G Cellot, G Modinos, GC Carlson, GE Hardingham, GS Tomassy, H Hu, H Lin, H Morishita, H Morishita, H Morishita, H Stefansson, HA Fachim, HC Brenhouse, HE Stevens, I Garate, J Coyle, J Egea, J Flatow, J Hirrlinger, J Rossier, J-H Cabungcal, JB Savitz, JC Kwok, JH Cabungcal, JH Cabungcal, JH Cabungcal, JH Cabungcal, JK Yao, JM Boyce-Rustay, JM Long, JM Yang, JM Yang, JP Debost, JW Young, K Fejgin, K Gill, K Munkholm, K Q Do, K Sakimura, KQ Do, KQ Do, L Lindemann, L Xin, LJ Kobrynski, LS Callahan, M Cuenod, M Didriksen, M Inan, M Inan, M Komitova, M Puhl, M Tosic, M Yanagi, MA Benneyworth, MJ Gandal, MM Behrens, MM Behrens, MW Pitts, N Brunetti-Pierri, N Gass, N Gogolla, NC Brown, O Akyol, O Kann, O Penagarikano, O Penagarikano, O Yizhar, P Fazzari, P Gravina, P O'Donnell, P O'Donnell, P Steullet, P Steullet, P Steullet, PB Walter, PJ Uhlhaas, R Gysin, S Ben-Shachar, S Giovanoli, S Giovanoli, S Schiavone, SA Mauney, SB Powell, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SK Natarajan, SM Purcell, SY Kim, T Hikida, T K Hensch, T M Maynard, T Sakai, T Stojkovic, T Vaessen, The Dutch-Belgian Fragile X Consortium, TM Maynard, U Meyer, U Meyer, V Labrie, Y Goldshmit, Y Zhang, Z Jiang   +128 more
core   +2 more sources

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

WFA-labeled perineuronal nets in the macaque claustrum [PDF]

Claustrum, 2018
The claustrum (CLA) has been discussed as central to integrated conscious percepts, although recent evidence has emphasized a role in detecting sensory novelty or in amplifying correlated cortical inputs.We report that many neurons in the macaque CLA are ensheathed in perineuronal nets (PNNs), which contribute to synaptic stability and enhance neuronal
Mihovil Pletikos, Kathleen S. Rockland
openaire   +2 more sources

Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay

Molecular Brain
Aerobic exercise has many effects on brain function, particularly at the hippocampus. Exercise has been shown to increase the rate of adult neurogenesis within the dentate gyrus and decrease the density of perineuronal nets in area CA1.
Dylan J. Terstege, Duneesha Goonetilleke, Cindy K. Barha, Jonathan R. Epp   +3 more
doaj   +1 more source