Results 71 to 80 of about 2,852 (175)

Adrenarche as a regulator of sensitivity to early adversity

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The human brain is highly sensitive to early adversity, which can have long‐term consequences for later mental health. It is also a time of rapid learning of social, motor and other skills, including language. It is proposed that pre‐adrenarche, the only epoch in human development in which cortisol is not accompanied by dehydroepiandrosterone (
J. Herbert
wiley   +1 more source

Screening Biomarkers for Nerve Injury Using Weighted Gene Co‐Expression Network Analysis and Machine Learning

Brain and Behavior, Volume 16, Issue 2, February 2026.
This study identifies Atf3, Bin2, Fcgr2b, and Ucn as key diagnostic genes for nerve injury, linking them to neuroinflammation and immune cell dynamics. Fcgr2b was further shown to functionally promote neurite outgrowth. ABSTRACT Background Nerve injury triggers complex molecular responses involving immune activation and neuronal damage, yet the key ...
Shuming Cao, Chengyue Yu, Nana Wang, Jianhua Xu, Weiguo Xu   +4 more
wiley   +1 more source

Perineuronal nets protect fast-spiking interneurons against oxidative stress [PDF]

Proceedings of the National Academy of Sciences, 2013
A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony during various sensory and cognitive tasks. The high metabolic requirements of these fast-spiking cells may render them susceptible to redox dysregulation and oxidative stress.
Cabungcal, Jan-Harry, Steullet, Pascal, Morishita, Hirofumi, Kraftsik, Rudolf, Cuenod, Michel, Hensch, Takao, Do, Kim Q.   +6 more
openaire   +4 more sources

Right medial temporal lobe mass in a 25‐year‐old male

Brain Pathology, EarlyView.
Jorge Samanamud, Cheyanne C. Slocum, Michael Christian Virata, Zied Abdullaev, Kenneth Aldape, Melissa Umphlett, Raymund L. Yong, Thomas P. Naidich, Nadejda M. Tsankova, Jamie M. Walker, Timothy E. Richardson   +10 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Targets in the Human Nodose Ganglion

Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.
Our findings demonstrate that the human nodose ganglion expresses Glp1r mRNA and reveal species similarities and differences in Glp1r expression between humans and mice. ABSTRACT Given the rapidly expanding clinical use of glucagon‐like peptide‐1 receptor (GLP1R) agonists—well‐known for their antidiabetic and antiobesity effects—it is increasingly ...
Warda Merchant, Claire Mackaaij, Cindy G. J. Cleypool, Laurent Gautron   +3 more
wiley   +1 more source

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

EBioMedicine, 2020
Background: Microglia, the brain's principal immune cell, are increasingly implicated in Alzheimer's disease (AD), but the molecular interfaces through which these cells contribute to amyloid beta (Aβ)-related neurodegeneration are unclear.
Joshua D. Crapser, Elizabeth E. Spangenberg, Rocio A. Barahona, Miguel A. Arreola, Lindsay A. Hohsfield, Kim N. Green   +5 more
doaj   +1 more source

D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2

The FEBS Journal, Volume 293, Issue 3, Page 766-780, February 2026.
Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua, Yee Song Chong, Sreedharan Sajikumar   +2 more
wiley   +1 more source

Combined Neuroprotective Effects of N,N‐Dimethyltryptamine and Ventral Root Reimplantation Following Spinal Root Avulsion in Rats

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
The ventral root avulsion (VRA) model provides an excellent experimental paradigm for studying injuries at the Central/Peripheral Nervous Systems (CNS/PNS) interface. By physically disconnecting motoneurons (MNs) from the spinal cord surface, VRA induces profound cellular, molecular, and functional deficits with limited spontaneous recovery.
Paola Andrea Caro Aponte, Edison Huertas Montoya, Italo O. Mazali, Alessandra Sussulini, Benedito Barraviera, Rui Seabra Ferreira Jr., Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +7 more
wiley   +1 more source

Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit

Neural Regeneration Research, 2015
We have previously found that unilateral labyrinthectomy is accompanied by modification of hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of rats and the time course of subsequent reorganization of ...
Botond Gaal, Einar Örn Jóhannesson, Amit Dattani, Agnes Magyar, Ildikó Wéber, Clara Matesz   +5 more
doaj   +1 more source

Cortical Layer‐Specific Remodelling of Parvalbumin and Perineuronal Net Networks in Alcohol Use Disorder

Neuropathology and Applied Neurobiology, Volume 52, Issue 1, February 2026.
Remodelling of perineuronal nets on cortical parvalbumin neurons in layers IV–VI occurs in human alcohol use disorder, suggests reduced plasticity in cortical output circuits driving habitual behaviour. ABSTRACT Background Alcohol use disorder (AUD) is a chronically relapsing condition marked by a pathological shift in behaviour, where excessive ...
Tamsin Karas, Asheeta A. Prasad
wiley   +1 more source