Results 81 to 90 of about 5,812 (218)

Perineuronal nets in brain physiology and disease

Seminars in Cell & Developmental Biology, 2019
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular matrix structures with heterogeneous composition yet specific organization. They typically assemble around a subset of fast-spiking interneurons that are implicated in learning and memory.
Damien Testa, Alain Prochiantz, Ariel A. Di Nardo   +2 more
openaire   +3 more sources

Cortical Layer‐Specific Remodelling of Parvalbumin and Perineuronal Net Networks in Alcohol Use Disorder

Neuropathology and Applied Neurobiology, Volume 52, Issue 1, February 2026.
Remodelling of perineuronal nets on cortical parvalbumin neurons in layers IV–VI occurs in human alcohol use disorder, suggests reduced plasticity in cortical output circuits driving habitual behaviour. ABSTRACT Background Alcohol use disorder (AUD) is a chronically relapsing condition marked by a pathological shift in behaviour, where excessive ...
Tamsin Karas, Asheeta A. Prasad
wiley   +1 more source

Early Destruction of the Extracellular Matrix around Parvalbumin-Immunoreactive Interneurons in Creutzfeldt-Jakob Disease

Neurobiology of Disease, 1999
GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko, Judith Miklossy, Brigitte Belser, Herbert Budka, Marco R. Celio   +4 more
doaj   +1 more source

Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder

Brain Sciences, 2023
Autism spectrum disorder (ASD) is associated with neurodevelopmental alterations, including atypical forebrain cellular organization. Mutations in several ASD-related genes often result in cerebral cortical anomalies, such as the abnormal developmental ...
Tanya Gandhi, Cade R. Canepa, Tolulope T. Adeyelu, Philip A. Adeniyi, Charles C. Lee   +4 more
doaj   +1 more source

Exploring the Production of Extracellular Matrix by Astrocytes in Response to Mimetic Traumatic Brain Injury [PDF]

, 2016
Following injury to the central nervous system, extracellular modulations are apparent at the site of injury, often resulting in a glial scar. Astrocytes are mechanosensitive cells, which can create a neuroinhibitory extracellular environment in response
Walker, Addison
core   +2 more sources

Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline [PDF]

, 2017
Learning to predict threat is a fundamental ability of many biological organisms, and a laboratory model for anxiety disorders. Interfering with such memories in humans would be of high clinical relevance.
BA Sorg, C Grillon, C Idzikowski, CC Chi, D Schiller, DR Bach, DR Bach, DR Bach, DR Bach, DR Bach, E Ahler, E Knapska, EA Antoniadis, ET Walters, F Faul, GD Gale, GW Huntley, IA Chatzispyrou, J Li, J Pinheiro, JE LeDoux, JM Pearce, JS Brown, K Nader, KW Spence, L Laux, LM Golub, M Davis, M Dziembowska, M Gawlak, M Hautzinger, M Karlsson, M Kindt, M Slaker, M Soeter, M Staib, Marijn C. W. Kroes, MJ Hylin, N Gogolla, PC Meighan, R Hanemaaijer, R Sjouwerman, RY Tsien, S Khemka, S Zhang, T Gorkiewicz, TE Brown, V Nagy, V Nagy, W Boucsein, WA Falls, WK Kirchner, XB Wang   +52 more
core   +2 more sources

Inhibitory circuit dysfunction as a potential contributor to cortical reorganization in Glioblastoma progression

Neurobiology of Disease
Glioblastoma (GBM) is a highly aggressive brain tumor that infiltrates surrounding brain tissue, profoundly affecting adjacent cortical areas. This study investigates how GBM reshapes the peritumoral cortex by examining plasticity changes in two GBM ...
Cristina Spalletti, Marta Scalera, Elisabetta Mori, Sabrin Haddad, Marco Mainardi, Daniele Cangi, Vinoshene Pillai, Elena Parmigiani, Silvia Landi, Matteo Caleo, Eleonora Vannini   +10 more
doaj   +1 more source

Toxoplasma gondii infection damages the perineuronal nets in a murine model [PDF]

Memorias do Instituto Oswaldo Cruz
BACKGROUND Behavioral and neurochemical alterations associated with toxoplasmosis may be influenced by the persistence of tissue cysts and activation of an immune response in the brain of Toxoplasma gondii-infected hosts.
Ywlliane da Silva Rodrigues Meurer, Ramayana Morais de Medeiros Brito, Valeria Palheta da Silva, Joelma Maria de Araujo Andade, Sarah Sophia Guedes Linhares, Antonio Pereira Junior, Valter Ferreira de Andrade-Neto, Andrea Lima de Sá, Claudio Bruno Silva de Oliveira   +8 more
doaj   +2 more sources

Tackling obstacles for gene therapy targeting neurons: disrupting perineural nets with hyaluronidase improves transduction. [PDF]

, 2013
Gene therapy has been proposed for many diseases in the nervous system. In most cases for successful treatment, therapeutic vectors must be able to transduce mature neurons. However, both in vivo, and in vitro, where preliminary characterisation of viral
Kovac, S, Schorge, S, Wanisch, K
core   +2 more sources

Anti‐Neuroinflammation Activity of Essential Oils and Fatty Acids

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Neuroinflammation plays a pivotal role in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Current pharmacological interventions, such as NSAIDs and corticosteroids, are limited by systemic toxicity and insufficient efficacy in targeting chronic neuroinflammatory processes.
Zelong Jin, Yige Song, Ahmed Attia Ahmed Abdelmoaty, Feng Lin, Jiujun Li, Xianyang Chen   +5 more
wiley   +1 more source