Results 31 to 40 of about 356,744 (339)

Rheostatic Balance of Circadian Rhythm and Autophagy in Metabolism and Disease

Frontiers in Cell and Developmental Biology, 2020
Circadian rhythms are physical, behavioral and environmental cycles that respond primarily to light and dark, with a period of time of approximately 24 h.
Xiang Wang, Zhijie Xu, Yuan Cai, Shuangshuang Zeng, Bi Peng, Xinxin Ren, Yuanliang Yan, Zhicheng Gong, Zhicheng Gong   +8 more
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A Circadian Clock inNeurospora:How Genes and Proteins Cooperate to Produce a Sustained, Entrainable, and Compensated Biological Oscillator with a Period of about a Day [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2007
Neurospora has proven to be a tractable model system for understanding the molecular bases of circadian rhythms in eukaryotes. At the core of the circadian oscillatory system is a negative feedback loop in which two transcription factors, WC-1 and WC-2 ...
Jay Dunlap, Jennifer Loros, Hildur V. Colot, A. Mehra, William J. Belden, Mi Shi, Christian I. Hong, Luis Larrondo, Christopher L. Baker, C.-H. Chen, Carsten Schwerdtfeger, Patrick D. Collopy, Joshua J. Gamsby, Randy Lambreghts   +13 more
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The Mammalian Circadian Clock Protein Period Counteracts Cryptochrome in Phosphorylation Dynamics of Circadian Locomotor Output Cycles Kaput (CLOCK) [PDF]

Journal of Biological Chemistry, 2014
The circadian transcription factor CLOCK exhibits a circadian oscillation in its phosphorylation levels. Although it remains unclear whether this phosphorylation contributes to circadian rhythm generation, it has been suggested to be involved in transcriptional activity, intracellular localization, and degradative turnover of CLOCK.
Ritsuko Matsumura, Yoshiki Tsuchiya, Isao T. Tokuda, Takahiro Matsuo, Miho Sato, Koichi Node, Eisuke Nishida, Makoto Akashi   +7 more
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O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression.

PLoS Genetics, 2019
Circadian clocks coordinate time-of-day-specific metabolic and physiological processes to maximize organismal performance and fitness. In addition to light and temperature, which are regarded as strong zeitgebers for circadian clock entrainment ...
Ying H Li, Xianhui Liu, Jens T Vanselow, Haiyan Zheng, Andreas Schlosser, Joanna C Chiu   +5 more
doaj   +2 more sources

Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.

PLoS ONE, 2013
The transcription/translation feedback loop-based molecular oscillator underlying the generation of circadian gene expression is preserved in almost all organisms.
Erik Engelen, Roel C Janssens, Kazuhiro Yagita, Veronique A J Smits, Gijsbertus T J van der Horst, Filippo Tamanini   +5 more
doaj   +2 more sources

Circadian PERIOD proteins sculpt the mammalian alternative splicing landscape

AbstractMammalian circadian oscillators are driven by a transcription-translation feedback loop where CLOCK:BMAL1 activity is repressed by the PER:CRY complex. While transcriptional regulation by PER is well established, the role of circadian feedback in co- and post- transcriptional processes remains unclear.
Lies Chikhaoui, K Mamgain, Masahide Seki, Carlos Blanco, F Sassolas, Eduardo J. Folco, Damien Sery, Yoshihito Suzuki, Bharath Ananthasubramaniam, K. A. Padmanabhan   +9 more
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The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice [PDF]

Journal of Clinical Investigation, 2009
The mineralocorticoid aldosterone is a major regulator of sodium transport in target epithelia and contributes to the control of blood pressure and cardiac function. It specifically functions to increase renal absorption of sodium from tubular fluid via regulation of the alpha subunit of the epithelial sodium channel (alphaENaC).
Michelle L. Gumz, Lisa R. Stow, I. Jeanette Lynch, Megan M. Greenlee, Alicia Rudin, Brian Cain, David R. Weaver, Charles S. Wingo   +7 more
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A New Clock is Running for Multiple Myeloma: Circadian Clock Protein-Period 3 (PER-3) Polymorphism [PDF]

Balkan Journal of Medical Genetics, 2022
ABSTRACT Circadian Clock Protein PERIOD 3 (PER-3) is situated on chromosome 1p36.23 and has a polymorphic domain that expresses 4 or 5 copies of the 54-bp tandem repeat sequence. PER-3 gene polymorphisms play a role in the dysregulation of the immune system.
İstemi Serin, Mustafa Pehlıvan, İbrahim Halil Demir, Yasemin Oyacı, Mustafa Pehlıvan   +4 more
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The tail of cryptochromes: an intrinsically disordered cog within the mammalian circadian clock

Cell Communication and Signaling, 2020
Cryptochrome (CRY) proteins play an essential role in regulating mammalian circadian rhythms. CRY is composed of a structured N-terminal domain known as the photolyase homology region (PHR), which is tethered to an intrinsically disordered C-terminal ...
Gian Carlo G. Parico, Carrie L. Partch
doaj   +2 more sources

Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression [PDF]

Cell, 2007
Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (approximately 26 hr) circadian mutant named Overtime (Ovtm). Positional cloning and genetic complementation reveal that Ovtm is encoded by the F-box protein FBXL3, a component of the SKP1-CUL1-F-box-protein (
Sandra M. Siepka, Seung Hee Yoo, Junghea Park, Weimin Song, Vivek Kumar, Yinin Hu, Choogon Lee, Joseph S. Takahashi   +7 more
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